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991.
Claire Berger Lonie Casagranda Hlne Sudour-Bonnange Catherine Massoubre Jean-Hugues Dalle Cecile Teinturier Sylvie Martin-Beuzart Pascale Guillot Virginie Lanlo Muriele Schneider Bernard Dal Molin Michle Dal Molin Olivier Mounier Arnauld Garcin Brice Fresneau Jacqueline Clavel Charlotte Demoor-Goldschmidt 《Applied clinical informatics》2021,12(2):237
Background Today, in France, it is estimated that 1 in 850 people aged between 20 and 45 years has been treated for childhood cancer, which equals 40,000 to 50,000 people. As late effects of the cancer and its treatment affect a large number of childhood cancer survivors (CCS) and only 30% of them benefit from an efficient long-term follow-up care for prevention, early detection, and treatment of late effects, health education of CCS represents a challenge of public health. Objectives Massive open online courses (MOOCs) are a recent innovative addition to the online learning landscape. This entertaining and practical tool could easily allow a deployment at a national level and make reliable information available for all the CCS in the country, wherever they live. Methods The MOOC team brings together a large range of specialists involved in the long-term follow-up care, but also associations of CCS, video producers, a communication consultant, a pedagogical designer, a cartoonist and a musician. We have designed three modules addressing transversal issues (lifestyle, importance of psychological support, risks of fertility problems) and eight modules covering organ-specific problems. Detailed data on childhood cancer treatments received were used to allocate the specific modules to each participant. Results This paper presents the design of the MOOC entitled “Childhood Cancer, Living Well, After,” and how its feasibility and its impact on CCS knowledge will be measured. The MOOC about long-term follow-up after childhood cancer, divided into 11 modules, involved 130 participants in its process, and resulted in a 170-minute film. The feasibility study included 98 CCS (31 males vs. 67 females; p < 0.0001). Conclusion Such personalized, free, and online courses with an online forum and a possible psychologist consultation based on unique characteristics and needs of each survivor population could improve adherence to long-term follow-up without alarming them unnecessarily. 相似文献
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Constantinos Zamboglou Peter Bronsert Simon Küsters Natalie Salm Marc Azèmar Thomas Brunner 《Strahlentherapie und Onkologie》2015,191(1):67-72
Background
Pancreatic cancer (PC) predominantly metastasizes to liver, lung, and peritoneum. Metastatic disease correlates with SMAD4 status. Musculoskeletal metastases (MSM) are rare in pancreatic cancer. The role of radiation therapy (RT) in patients with musculoskeletal metastases is not clear.Methods
We present a case of a woman with musculoskeletal metastases of PC evolving 4 years after Whipple’s procedure and adjuvant therapy. She was treated with RT for 7 MSM. Radiation dose was 15–45 Gy, delivered in doses of 2.5–5 Gy per fraction. SMAD4 status was examined by immunohistochemistry. Furthermore we undertook a review of the literature to examine the value of RT in musculoskeletal metastasis of PC.Results
In the presented patient we treated 7 MSM of SMAD4-mutant PC with RT. RT achieved local control in 4 of the 7 MSM. At the resection margin of one MSM recurrent tumor was observed after RT. The status of one MSM was unknown and one MSM showed local progression. Follow-up revealed progression of pain in 1 of the 7 MSM. Except of hyperpigmentation no side effects occurred. There was no dose–correlation effect on tumor control observed. A review of the literature showed that a musculoskeletotrophic phenotype of metastases is rare in PC. MSM of PC are rapidly increasing soft tissue masses causing pain and loss of anatomical function. RT as a treatment option for musculoskeletal metastasis is described in the current literature in only 2 cases. Radiotherapy aims to achieve local control, pain relief, and to maintain anatomical function.Conclusion
Radiotherapy is an effective and well-tolerated approach for multiple musculoskeletal metastases of PC.995.
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Gitta Bleeker Berthe L. van Eck-Smit Koos H. Zwinderman Rogier Versteeg Max M. van Noesel Boen L. Kam Gertjan J. Kaspers Annelies van Schie Susan G. Kreissman Gregory Yanik Barbara Hero Matthias Schmidt Geneviève Laureys Bieke Lambert Ingrid Øra Johannes H. Schulte Huib N. Caron Godelieve A. Tytgat 《European journal of nuclear medicine and molecular imaging》2015,42(2):222-230
999.
Treatment of pleural malignancies by photo‐induction combined to systemic chemotherapy: Proof of concept on rodent lung tumors and feasibility study on porcine chest cavities
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1000.
Prospective evaluation of ambulatory laser vaporization of the prostate for benign prostatic hyperplasia
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