全文获取类型
收费全文 | 3003篇 |
免费 | 182篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 82篇 |
妇产科学 | 43篇 |
基础医学 | 374篇 |
口腔科学 | 86篇 |
临床医学 | 216篇 |
内科学 | 770篇 |
皮肤病学 | 116篇 |
神经病学 | 313篇 |
特种医学 | 67篇 |
外科学 | 300篇 |
综合类 | 9篇 |
预防医学 | 181篇 |
眼科学 | 68篇 |
药学 | 234篇 |
中国医学 | 9篇 |
肿瘤学 | 313篇 |
出版年
2024年 | 4篇 |
2023年 | 33篇 |
2022年 | 48篇 |
2021年 | 93篇 |
2020年 | 57篇 |
2019年 | 90篇 |
2018年 | 96篇 |
2017年 | 69篇 |
2016年 | 66篇 |
2015年 | 77篇 |
2014年 | 111篇 |
2013年 | 122篇 |
2012年 | 228篇 |
2011年 | 257篇 |
2010年 | 113篇 |
2009年 | 81篇 |
2008年 | 175篇 |
2007年 | 179篇 |
2006年 | 184篇 |
2005年 | 167篇 |
2004年 | 154篇 |
2003年 | 127篇 |
2002年 | 146篇 |
2001年 | 30篇 |
2000年 | 43篇 |
1999年 | 38篇 |
1998年 | 31篇 |
1997年 | 23篇 |
1996年 | 17篇 |
1995年 | 20篇 |
1994年 | 19篇 |
1993年 | 15篇 |
1992年 | 32篇 |
1991年 | 28篇 |
1990年 | 22篇 |
1989年 | 37篇 |
1988年 | 23篇 |
1987年 | 19篇 |
1986年 | 15篇 |
1985年 | 19篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1982年 | 5篇 |
1980年 | 5篇 |
1979年 | 12篇 |
1978年 | 6篇 |
1977年 | 10篇 |
1976年 | 6篇 |
1974年 | 5篇 |
1971年 | 6篇 |
排序方式: 共有3201条查询结果,搜索用时 15 毫秒
71.
Masatoshi Katagiri Hiroyuki Ito Yasuo Murayama Megumi Hamada Syunji Nakajima Nobuya Takayanagi Ai Uemiya Mitsunori Myogan Akio Nakai Masatsugu Tsujii 《Brain & development》2021,43(5):605-615
BackgroundDifficulties in fine and gross motor skills are often overlooked as developmental problems, although approximately 6–13% of all school-age children have poor motor coordination. Understanding motor coordination is important from the perspective of school adaptation. This longitudinal cohort study aimed to determine whether fine and gross motor skills in preschool children predict later academic achievement and psychosocial maladaptation.Methods & ProceduresParticipants were 2,501 children from nursery and elementary schools (5–13 years old). The motor skills of preschool children were assessed by their nursery teacher immediately before entering elementary school. The Strengths and Difficulties Questionnaire and a standardized Japanese test were administered annually throughout elementary school.ResultsEarly motor difficulties in preschool children had significant effects on their academic achievement and psychosocial maladaptation up until the sixth grade. Gross motor difficulties in preschool were associated with the later peer problems and worsened emotional symptoms.ConclusionsMotor skills in preschool children are useful as a predictor of later psychosocial maladaptation and academic achievement. 相似文献
72.
Akiyoshi Hizukuri Ryohei Nakayama Mayumi Nara Megumi Suzuki Kiyoshi Namba 《Journal of digital imaging》2021,34(1):116
Although magnetic resonance imaging (MRI) has a higher sensitivity of early breast cancer than mammography, the specificity is lower. The purpose of this study was to develop a computer-aided diagnosis (CAD) scheme for distinguishing between benign and malignant breast masses on dynamic contrast material-enhanced MRI (DCE-MRI) by using a deep convolutional neural network (DCNN) with Bayesian optimization. Our database consisted of 56 DCE-MRI examinations for 56 patients, each of which contained five sequential phase images. It included 26 benign and 30 malignant masses. In this study, we first determined a baseline DCNN model from well-known DCNN models in terms of classification performance. The optimum architecture of the DCNN model was determined by changing the hyperparameters of the baseline DCNN model such as the number of layers, the filter size, and the number of filters using Bayesian optimization. As the input of the proposed DCNN model, rectangular regions of interest which include an entire mass were selected from each of DCE-MRI images by an experienced radiologist. Three-fold cross validation method was used for training and testing of the proposed DCNN model. The classification accuracy, the sensitivity, the specificity, the positive predictive value, and the negative predictive value were 92.9% (52/56), 93.3% (28/30), 92.3% (24/26), 93.3% (28/30), and 92.3% (24/26), respectively. These results were substantially greater than those with the conventional method based on handcrafted features and a classifier. The proposed DCNN model achieved high classification performance and would be useful in differential diagnoses of masses in breast DCE-MRI images as a diagnostic aid. 相似文献
73.
74.
Yu Oyama Megumi Yasunaga Akira Honda Hiroaki Maki Yosuke Masamoto Tatsuya Kobayashi Yoshitaka Wakabayashi Shu Okugawa Kyoji Moriya Mineo Kurokawa 《Journal of infection and chemotherapy》2021,27(5):770-772
Achromobacter xylosoxidans (A. xylosoxidans) is an aerobic gram-negative bacillus and often isolated from aquatic environments. It is supposed to cause infections in patients with malignancy or immunodeficiency. It causes various healthcare-associated infections, but cellulitis is rare. Herein, we report the first case of sever cellulitis by A. xylosoxidans after allogeneic hematopoietic stem cell transplantation (HSCT). A 49-year-old man underwent allogeneic HSCT from 8/8 HLA-matched unrelated donor with myeloablative conditioning for relapsed acute myeloid leukemia. He developed skin chronic graft versus host disease 11 months after HSCT. During the prolonged treatment with prednisolone and cyclosporine, he developed cellulitis on his left leg and admitted to our hospital. Blood and exudate culture revealed A. xylosoxidans. Although empirical therapy with cefepime was ineffective, his symptoms were dramatically improved after administration of meropenem. To our knowledge, this is the first case of A. xylosoxidans cellulitis after allogeneic HSCT. A. xylosoxidans should be considered as a possible cause of cellulitis in post-allogeneic HSCT patients on prolonged immunosuppressive therapy. 相似文献
75.
76.
Ultrasonographic evaluation of gastrointestinal graft‐versus‐host disease after hematopoietic stem cell transplantation
下载免费PDF全文
![点击此处可从《Clinical transplantation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mutsumi Nishida Akio Shigematsu Megumi Sato Yusuke Kudo Satomi Omotehara Tatsunori Horie Takahito Iwai Tomoyuki Endo Akihiro Iguchi Hitoshi Shibuya Kanako Hatanaka Chikara Shimizu Takanori Teshima 《Clinical transplantation》2015,29(8):697-704
Gastrointestinal graft‐versus‐host disease (GI‐GVHD) is a major and life‐threatening complication of hematopoietic stem cell transplantation (HSCT). This study evaluated the efficacy of ultrasonography (US) for assessing and monitoring GI‐GVHD. GI tract was evaluated by US in 81 patients. US findings were positive in 43 patients, including 11 false positive, and negative in 38 patients. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of US for the diagnosis of GI‐GVHD were 100%, 78%, 74%, 100%, and 86%, respectively. Diffuse wall thickening of the ileum was the most frequent finding in patients with GI‐GVHD. Severity of GI‐GVHD was correlated with the thickness of internal low echoic layer of the wall, the echogenicity of mesenteric fat tissue, and the intensity of Doppler signaling. We classified US findings of GI‐GVHD into four US grades. There was a significant correlation between clinical stage of GI‐GVHD and the US grade. These ultrasonographic abnormalities were improved with clinical improvement of GI‐GVHD upon treatment. Thus, US is an effective and efficient non‐invasive means of identifying the extent and severity of GI‐GVHD and monitoring response to treatment. 相似文献
77.
T Funakoshi Y Ueda A Kobayashi H Morikawa M Mochizuki 《Nippon Naibunpi Gakkai zasshi》1990,66(7):688-699
In order to elucidate the roles of Insulin-like Growth Factors (IGF-I, -II) in human pregnancy, the levels of IGF-I and IGF-II, the distribution of binding proteins for IGF-I or IGF-II and profiles of unsaturated somatomedin binding proteins (USBP) were estimated in maternal and cord plasma. IGF-I levels in maternal plasma gradually elevated in late gestation, reaching 304.4 +/- 130.1ng/ml at term, and were significantly higher than those in nonpregnant women (188 +/- 58). IGF-II levels, which were 414.9 +/- 75.4ng/ml in women in the third trimester of gestation, did not produce any remarkable changes in the levels in nonpregnant women (395.9 +/- 72.6). On the other hand, IGF-I in cord plasma also increased according to gestational age, reaching 37.3 +/- 14.6ng/ml at term, but it was significantly lower than that in maternal weight (r = 0.50, p less than 0.005) and relative birth weight (r = 0.41, p less than 0.005). IGF-II in cord plasma showed no significant changes during gestation, however, IGF-II levels in AFD (appropriate for date) newborns delivered at term (203.8 +/- 59.4) were significantly lower than those in maternal plasma. And they had no positive correlations with birth weight and relative birth weight. On Sephadex G150 gel-chromatography of cord plasma from AFD newborns at term, more than 70% of immunoreactive IGF-I in plasma was eluted at 150K region, and 150K USBP could be detected as observed in adult plasma. On the other hand, most of the immunoreactive IGF-II was eluted at 40K region, and 150K USBP was not detected in AFD newborns at term. In adult plasma, most of the immunoreactive IGF-II was eluted at 150K region, but 150K USBP could not be detected. From these results, it is supposed that IGF-I plays an essential role in fetal growth rather than IGF-II. 相似文献
78.
Magnifying endoscope with NBI to predict the depth of invasion in laryngo‐pharyngeal cancer
下载免费PDF全文
![点击此处可从《The Laryngoscope》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ichiro Tateya MD PhD Shuko Morita MD Manabu Muto MD PhD Shin'ichi Miyamoto MD PhD Tomomasa Hayashi MD PhD Makiko Funakoshi MD Ikuo Aoyama MD Shigeru Hirano MD PhD Morimasa Kitamura MD PhD Seiji Ishikawa MD PhD Yo Kishimoto MD PhD Mami Morita MD Patnarin Mahattanasakul MD Satoshi Morita PhD Juichi Ito MD PhD 《The Laryngoscope》2015,125(5):1124-1129
79.
Lu Zhang Eman A. Hamad Mélanie Vausort Hajime Funakoshi Arthur M. Feldman Daniel R. Wagner Yvan Devaux 《CTS Clinical and Translational Science》2015,8(2):100-106
Purpose
Long noncoding RNAs (lncRNAs) constitute an emerging group of noncoding RNAs, which regulate gene expression. Their role in cardiac disease is poorly known. Here, we investigated the association between lncRNAs and left ventricular hypertrophy.Methods
Wild‐type and adenosine A2A receptor overexpressing mice (A2A‐Tg) were subjected to transverse aortic constriction (TAC) and expression of lncRNAs in the heart was investigated using genome‐wide microarrays and an analytical pipeline specifically developed for lncRNAs.Results
Microarray analysis identified two lncRNAs up‐regulated and three down‐regulated in the hearts of A2A‐Tg mice subjected to TAC. Quantitative PCR showed that lncRNAs 2900055J20Rik and Gm14005 were decreased in A2A‐Tg mice (3.5‐ and 1.8‐fold, p < 0.01). We found from public microarray dataset that 2900055J20Rik and Gm14005 were increased in TAC mice compared to sham‐operated animals (1.8‐ and 1.4‐fold, after 28 days, p < 0.01). Interestingly, in this public dataset, cardioprotective drug JQ1 decreased 2900055J20Rik and Gm14005 expression by 2.2‐ and 1.6‐fold (p < 0.01).Conclusions
First, we have shown that data on lncRNAs can be obtained from gene expression microarrays. Second, expression of lncRNAs 2900055J20Rik and Gm14005 is regulated after TAC and can be modulated by cardioprotective molecules. These observations motivate further investigation of the therapeutic value of lncRNAs in the heart. 相似文献80.
Selenium deficiency in a patient with Crohn's disease receiving long-term total parenteral nutrition
Ishida T Himeno K Torigoe Y Inoue M Wakisaka O Tabuki T Ono H Honda K Mori T Seike M Yoshimatsu H Sakata T 《Internal medicine (Tokyo, Japan)》2003,42(2):154-157
We report a case of selenium deficiency in a patient with Crohn's disease on long-term total parenteral nutrition (TPN). She manifested lassitude of the legs, discoloration of the nail beds, and macrocytosis. Since her plasma selenium level was found to be below the measurable level, we diagnosed this case as selenium deficiency. After intravenous administration of sodium selenite, her symptoms were reversed. Careful attention should be paid to selenium deficiency when a patient receives long-term TPN; supplementary administration of selenium via TPN may be required because selenium is often not routinely added to TPN formulations. 相似文献