全文获取类型
收费全文 | 10161篇 |
免费 | 681篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 116篇 |
儿科学 | 268篇 |
妇产科学 | 231篇 |
基础医学 | 1658篇 |
口腔科学 | 298篇 |
临床医学 | 1013篇 |
内科学 | 1492篇 |
皮肤病学 | 502篇 |
神经病学 | 1137篇 |
特种医学 | 481篇 |
外科学 | 1471篇 |
综合类 | 118篇 |
一般理论 | 6篇 |
预防医学 | 642篇 |
眼科学 | 216篇 |
药学 | 489篇 |
中国医学 | 1篇 |
肿瘤学 | 747篇 |
出版年
2023年 | 75篇 |
2022年 | 129篇 |
2021年 | 270篇 |
2020年 | 154篇 |
2019年 | 209篇 |
2018年 | 231篇 |
2017年 | 168篇 |
2016年 | 206篇 |
2015年 | 209篇 |
2014年 | 324篇 |
2013年 | 396篇 |
2012年 | 576篇 |
2011年 | 529篇 |
2010年 | 307篇 |
2009年 | 241篇 |
2008年 | 446篇 |
2007年 | 487篇 |
2006年 | 394篇 |
2005年 | 460篇 |
2004年 | 424篇 |
2003年 | 406篇 |
2002年 | 384篇 |
2001年 | 105篇 |
2000年 | 93篇 |
1999年 | 124篇 |
1998年 | 104篇 |
1997年 | 87篇 |
1996年 | 83篇 |
1995年 | 56篇 |
1994年 | 55篇 |
1993年 | 66篇 |
1992年 | 73篇 |
1991年 | 55篇 |
1990年 | 60篇 |
1988年 | 66篇 |
1987年 | 62篇 |
1985年 | 68篇 |
1984年 | 54篇 |
1983年 | 55篇 |
1982年 | 69篇 |
1980年 | 64篇 |
1931年 | 50篇 |
1930年 | 61篇 |
1926年 | 54篇 |
1923年 | 54篇 |
1922年 | 54篇 |
1921年 | 51篇 |
1914年 | 51篇 |
1913年 | 79篇 |
1911年 | 50篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
61.
William E. Gathings Rose G. Mawo Max D. Cooper Glendowlyn O. Young-Cooper 《European journal of immunology》1982,12(1):76-81
The expression of immunoglobulin heavy and light chains by pre-B cells and B lymphocytes was examined by two-color immunofluorescence in heterozygous b5b9 rabbits. Allelic exclusion of b5 and b9 x light chain allotypes was observed for both surface immunoglobulin-negative pre-B cells and surface immunoglobulin-positive B lymphocytes. In newborn bone marrow, pre-B cells and immature B lymphocytes expressing b9 were as numerous as those expressing b5. In contrast, circulating B cells and bone marrow plasma cells expressing the b5 marker outnumber b9+ cells by 2 to 1 in adult b5b9 animals. Whereas most B lymphocytes expressed x light chain b allotypes, approximately 80% of the μ heavy chain-positive pre-B cells did not. The pre-B cells that expressed detectable light chains were relatively small lymphocytes. A model is presented which includes a “transitional” pre-B cell that expresses both p chains and x chains. 相似文献
62.
Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection 总被引:6,自引:0,他引:6
Bannerman DD Paape MJ Lee JW Zhao X Hope JC Rainard P 《Clinical and diagnostic laboratory immunology》2004,11(3):463-472
Staphylococcus aureus and Escherichia coli are among the most prevalent species of gram-positive and gram-negative bacteria, respectively, that induce clinical mastitis. The innate immune system comprises the immediate host defense mechanisms to protect against infection and contributes to the initial detection of and proinflammatory response to infectious pathogens. The objective of the present study was to characterize the different innate immune responses to experimental intramammary infection with E. coli and S. aureus during clinical mastitis. The cytokine response and changes in the levels of soluble CD14 (sCD14) and lipopolysaccharide-binding protein (LBP), two proteins that contribute to host recognition of bacterial cell wall products, were studied. Intramammary infection with either E. coli or S. aureus elicited systemic changes, including decreased milk output, a febrile response, and induction of the acute-phase synthesis of LBP. Infection with either bacterium resulted in increased levels of interleukin 1beta (IL-1beta), gamma interferon, IL-12, sCD14, and LBP in milk. High levels of the complement cleavage product C5a and the anti-inflammatory cytokine IL-10 were detected at several time points following E. coli infection, whereas S. aureus infection elicited a slight but detectable increase in these mediators at a single time point. Increases in IL-8 and tumor necrosis factor alpha were observed only in quarters infected with E. coli. Together, these data demonstrate the variability of the host innate immune response to E. coli and S. aureus and suggest that the limited cytokine response to S. aureus may contribute to the well-known ability of the bacterium to establish chronic intramammary infection. 相似文献
63.
Fink M 《Convulsive therapy》1985,1(3):204-216
The origins of convulsive therapy, its early developments, present practice, central elements of the treatment, and neurohumoral and neuroendocrine theories of its antidepressant action are reviewed on the 50th anniversary of its introduction. 相似文献
64.
65.
Serial dexamethasone suppression tests (DST), obtained during a course of electroconvulsive therapy in 43 severely depressed patients, did not exhibit relationships between the initial DST, final DST, or the change in DST with clinical outcome measures at the time of discharge. In 37 patients reviewed six months after discharge, no relationship with the continuation of improvement, rehospitalization, or suicide was found. We are unable to confirm a clinical application for the DST in the management of patients during a course of convulsive therapy. 相似文献
66.
67.
In addition to the main flavonol glycoside spiraeoside in bulbs of ALLIUM CEPA L., kaempferol-4'-glucoside ( 1) has been found in smaller amounts. Traces of other flavonoids could be detected also. 相似文献
68.
Emergency department thoracotomy (EDT). A 26-month experience using an "agonal" protocol 总被引:1,自引:0,他引:1
EDT can be successfully performed with the proper system in place. This includes an established thoracotomy protocol, a well-integrated EMS system, and an in-house team. Time seems to be critical, and the time between injury and EDT may be the single most important factor affecting survival other than the mechanism of injury. Cardiac penetrations, especially stab wounds, were found to have a 93 per cent survival while subdiaphragmatic penetrations had only one survivor from a group of 18 patients (5.5%). The high rate of salvage in the heart wound group probably reflects the speed of prehospital transport, though all other major series have found this group to gain the maximum benefit. No patient was successfully resuscitated from blunt injury with EDT. Three additional patients had "signs of life" restored (one pediatric blunt; two subdiaphragmatic gunshot wounds) but died of coagulopathies shortly thereafter. The experience with air ambulance patients was far too small to allow any conclusions or observations. It is felt that as the use and application of helicopters to EMS situations becomes widespread, more patients will be arriving at trauma centers with no vital signs and massive blunt injury but only moments from the accident. This special group of "dying" patients will require intense scrutiny and possibly new and inventive approaches for any hopeful salvage. Emergency thoracotomy will, no doubt, have a place as part of this. The development of a simple working protocol is of extreme importance. The protocol should be one that will allow maximum selection of patients who can benefit and elimination of those patients where EDT would be useless. The primary benefactor for EDT remains the patient sustaining a stab wound to the heart who arrives at the center shortly after injury. In other areas, such as abdominal exsanguination or severe blunt injury, further study is needed to determine what factors, prehospital and resuscitative, will improve outcome. 相似文献
69.
70.
Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice