全文获取类型
收费全文 | 3702篇 |
免费 | 169篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 93篇 |
妇产科学 | 15篇 |
基础医学 | 449篇 |
口腔科学 | 79篇 |
临床医学 | 259篇 |
内科学 | 1051篇 |
皮肤病学 | 57篇 |
神经病学 | 183篇 |
特种医学 | 178篇 |
外科学 | 784篇 |
综合类 | 14篇 |
预防医学 | 70篇 |
眼科学 | 36篇 |
药学 | 217篇 |
中国医学 | 19篇 |
肿瘤学 | 383篇 |
出版年
2023年 | 20篇 |
2022年 | 50篇 |
2021年 | 85篇 |
2020年 | 50篇 |
2019年 | 63篇 |
2018年 | 90篇 |
2017年 | 95篇 |
2016年 | 88篇 |
2015年 | 117篇 |
2014年 | 136篇 |
2013年 | 179篇 |
2012年 | 240篇 |
2011年 | 278篇 |
2010年 | 153篇 |
2009年 | 142篇 |
2008年 | 210篇 |
2007年 | 239篇 |
2006年 | 217篇 |
2005年 | 253篇 |
2004年 | 237篇 |
2003年 | 232篇 |
2002年 | 197篇 |
2001年 | 40篇 |
2000年 | 34篇 |
1999年 | 43篇 |
1998年 | 39篇 |
1997年 | 28篇 |
1996年 | 39篇 |
1995年 | 38篇 |
1994年 | 21篇 |
1993年 | 23篇 |
1992年 | 10篇 |
1991年 | 15篇 |
1990年 | 11篇 |
1989年 | 17篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 13篇 |
1985年 | 12篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 14篇 |
1980年 | 12篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1974年 | 7篇 |
1969年 | 7篇 |
1967年 | 5篇 |
排序方式: 共有3898条查询结果,搜索用时 15 毫秒
61.
Kazuhiro Masada Masataka Yasuda Hideo Hashimoto Ken-Ichiro Nakai 《Journal of plastic surgery and hand surgery》2013,47(4):243-244
We report a case of rupture of the flexor tendons to the index finger after arthrodesis of the basal joint of the thumb. The tendons ruptured as a result of the Kirschner wires having penetrated in the carpal tunnel. This unusual complication was treated by tendon graft of the palmaris longus tendon. 相似文献
62.
63.
Masataka Suwa 《Journal of Physical Therapy Science》2021,33(1):37
[Purpose] To examine the correlation between toe flexor strength (TFS) and physical fitness performance measurements and their gender differences in the elderly. [Participants and Methods] Japanese males (n=50) and females (n=121), aged 65–88 years, participated in this study. We measured TFS, handgrip strength (HGS), knee extensor strength (KES), sit-and-reach distance (SR), and functional reach (FR). [Results] The female participants had significantly lower TFS, KES, and HGS than the male participants; however, the female participants had a significantly higher SR than that the male participants. FR was not significantly different between males and females. In males, TFS was significantly correlated with HGS, KES, SR, and FR. In females, TFS had correlations with HGS, KES, and FR; however, no correlation with SR was found. We could observe these correlations even after adjustment for age and body weight. [Conclusion] Elderly male had higher TFS than elderly females. In addition, TFS was correlated with all the physical fitness measurements in the male participants and all the measurements except for SR in the female participants. Gender and aging may explain the inconsistent results between SR and other physical fitness performance measurements.Key words: Toe grip, Aging, Physical fitness 相似文献
64.
65.
66.
Pyoderma gangrenosum is an ulcerative skin disorder showing characteristic non‐infectious ulcers and affects the lower extremities in approximately 70% of cases. Pyoderma gangrenosum is commonly associated with systemic diseases such as inflammatory bowel disease, rheumatoid arthritis and hematological malignancies. Herein, we report two cases of Japanese patients diagnosed with genital pyoderma gangrenosum. Case 1 was a 74‐year‐old woman without associated systemic complications, whose skin lesion resembled a squamous cell carcinoma and was limited to the vulva. Case 2 is an 89‐year‐old man, who suffered from myelodysplastic syndrome and acute myeloid leukemia, and presented with penile and leg ulcers mimicking pressure sores. Both cases responded well to systemic steroids. We review 13 genital pyoderma gangrenosum cases (76.9% male; aged 30–89 years) from 1996 to 2012 in Japan, including 11 previously reported cases and the present study's two cases. Four of the 13 genital pyoderma gangrenosum cases had associated systemic diseases and their skin lesions spread to the extragenital areas. Eight of the remaining nine genitalia‐localized pyoderma gangrenosum cases had no associated systemic diseases. In conclusion, genital pyoderma gangrenosum is rare and may be misdiagnosed. It should therefore be considered in cases of refractory genital ulcers. In addition, genitalia‐localized pyoderma gangrenosum tends to be without systemic complications. 相似文献
67.
68.
Kazuyuki Hanajiri Hiroshi Mitsui Toshiyuki Maruyama Naoaki Hashimoto Masataka Sata Masao Omata 《Journal of gastroenterology and hepatology》2009,24(5):866-871
Background and Aim: There have so far been few reports describing echographic studies of chemically-induced carcinogenesis in rodent livers. Using echography, we observed diethylnitrosamine-induced liver tumors in rats and examined the effect of an intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Methods: Male Wistar rats were given 100 ppm of diethylnitrosamine for 6 weeks and their liver nodules were examined by echography weekly. The size of the nodules was measured and they were examined histologically. The effect of SP600125, an inhibitor of c-Jun N-terminal kinase, on the growth of rat hepatoma cell line McA-RH7777 was tested in vitro . Thereafter, SP600125 was injected into the liver nodules under echographic guidance in vivo and the changes in the proliferating cell nuclear antigen expression and size of the nodules were examined.
Results: The four distinct lobes of rat livers were clearly observed by transabdominal echography. The nodules in the livers were first detected 6 weeks after the treatment began, when they were as small as 1.6 mm in diameter. The nodules thereafter became more malignant histologically as they grew larger than 4 mm. SP600125 decreased the expression of proliferating cell nuclear antigen and the growth of McA-RH7777 cells. After SP600125 was injected in vivo , the proliferating cell nuclear antigen level and the growth rate of the rat liver nodules all significantly decreased.
Conclusions: Our results indicate that echography is quite useful for follow-up studies of liver carcinogenesis in rats, and c-Jun N-terminal kinase might be another therapeutic target in liver neoplasms. 相似文献
Methods: Male Wistar rats were given 100 ppm of diethylnitrosamine for 6 weeks and their liver nodules were examined by echography weekly. The size of the nodules was measured and they were examined histologically. The effect of SP600125, an inhibitor of c-Jun N-terminal kinase, on the growth of rat hepatoma cell line McA-RH7777 was tested in vitro . Thereafter, SP600125 was injected into the liver nodules under echographic guidance in vivo and the changes in the proliferating cell nuclear antigen expression and size of the nodules were examined.
Results: The four distinct lobes of rat livers were clearly observed by transabdominal echography. The nodules in the livers were first detected 6 weeks after the treatment began, when they were as small as 1.6 mm in diameter. The nodules thereafter became more malignant histologically as they grew larger than 4 mm. SP600125 decreased the expression of proliferating cell nuclear antigen and the growth of McA-RH7777 cells. After SP600125 was injected in vivo , the proliferating cell nuclear antigen level and the growth rate of the rat liver nodules all significantly decreased.
Conclusions: Our results indicate that echography is quite useful for follow-up studies of liver carcinogenesis in rats, and c-Jun N-terminal kinase might be another therapeutic target in liver neoplasms. 相似文献
69.
Motohiro Hirao Hideyasu Omiya Koji Takami Kazuyoshi Yamamoto Kazuhiro Nishikawa Masataka Ikeda Atsushi Miyamoto Naoki Hama Masakazu Miyake Mamoru Uemura Sakae Maeda Shoji Nakamori Mitsugu Sekimoto 《Esophagus》2016,13(2):163-166
Background and objective
Pulmonary metastasectomy is a standard therapy for some types of metastatic lesions in the lung. Although the prognosis for esophageal cancer patients with pulmonary metastasis is poor, it has been reported that some post-esophagectomy patients have good prognosis after pulmonary metastasectomy. We investigated the role of resecting pulmonary metastases arising from esophageal cancer at our institution.Patients and methods
Seven patients with primary squamous cell carcinoma or adenocarcinoma of the thoracic esophagus who underwent resection of metachronous pulmonary metastases at our institution between 2006 and 2012 were identified from a retrospective database. All patients had undergone curative resection of their primary esophageal carcinoma.Results
Six patients had unilateral and solitary lung metastasis. One patient presented with one metastatic lesion on each side, and he underwent 4 metastasectomy for pulmonary metastasis 3 times. There was no perioperative morbidity or mortality. The disease-free interval after esophagectomy ranged from 191 to 559 days (median, 463 days). Survival after pulmonary metastasectomy ranged from 357 to 3191 days (median, 1803 days). Three patients received systemic chemotherapy before metastasectomy. Currently, 5 patients are alive without evidence of recurrent disease.Conclusion
Pulmonary metastasectomy may be acceptable as a part of multimodal treatment for solitary metachronous pulmonary metastasis in esophageal carcinoma.70.
Masaki Y Sumiyoshi M Suwa S Ohta H Matsunaga E Tamura H Takaya N Mineda Y Kojima S Nakata Y 《International heart journal》2005,46(2):323-326
Dissection of the sinus of Valsalva is an extremely rare accident during percutaneous coronary intervention (PCI), but it can lead to serious complications such as dissection of the ascending aorta. We experienced a localized dissection of the right coronary cusp without coronary artery involvement that was induced by a guiding catheter during PCI in a patient with acute myocardial infarction. The localized dissection showed pooling of the contrast medium in the acute phase, but it subsided spontaneously after 12 days without any sequelae. Manipulation of the guiding catheter should be performed with great caution not only in the coronary artery but also in the sinus of Valsalva. 相似文献