全文获取类型
收费全文 | 10993篇 |
免费 | 561篇 |
国内免费 | 104篇 |
专业分类
耳鼻咽喉 | 103篇 |
儿科学 | 248篇 |
妇产科学 | 106篇 |
基础医学 | 1067篇 |
口腔科学 | 160篇 |
临床医学 | 759篇 |
内科学 | 3088篇 |
皮肤病学 | 149篇 |
神经病学 | 647篇 |
特种医学 | 380篇 |
外科学 | 2171篇 |
综合类 | 62篇 |
预防医学 | 234篇 |
眼科学 | 151篇 |
药学 | 781篇 |
中国医学 | 17篇 |
肿瘤学 | 1535篇 |
出版年
2023年 | 87篇 |
2022年 | 170篇 |
2021年 | 301篇 |
2020年 | 187篇 |
2019年 | 231篇 |
2018年 | 269篇 |
2017年 | 243篇 |
2016年 | 283篇 |
2015年 | 308篇 |
2014年 | 363篇 |
2013年 | 434篇 |
2012年 | 730篇 |
2011年 | 763篇 |
2010年 | 442篇 |
2009年 | 358篇 |
2008年 | 598篇 |
2007年 | 636篇 |
2006年 | 665篇 |
2005年 | 679篇 |
2004年 | 642篇 |
2003年 | 643篇 |
2002年 | 637篇 |
2001年 | 164篇 |
2000年 | 150篇 |
1999年 | 169篇 |
1998年 | 118篇 |
1997年 | 98篇 |
1996年 | 91篇 |
1995年 | 77篇 |
1994年 | 85篇 |
1993年 | 72篇 |
1992年 | 93篇 |
1991年 | 113篇 |
1990年 | 84篇 |
1989年 | 90篇 |
1988年 | 93篇 |
1987年 | 60篇 |
1986年 | 52篇 |
1985年 | 45篇 |
1984年 | 35篇 |
1983年 | 38篇 |
1982年 | 17篇 |
1981年 | 14篇 |
1980年 | 17篇 |
1979年 | 35篇 |
1978年 | 19篇 |
1973年 | 14篇 |
1971年 | 16篇 |
1969年 | 19篇 |
1966年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
Imamura Hitoshi Maruyama Toru Okabe Hiroaki Shimada Hidekata Otagiri Masaki 《Pharmaceutical research》1994,11(4):566-570
We examined different fluorescent probes suitable for fluorometric determination of 1-acid glycoprotein (AGP) in serum. Quinaldine red (QR) was shown to bind strongly and selectively to AGP. Taking advantage of the enhanced fluorescence of QR in the presence of AGP, we developed a direct method for the determination of serum AGP without removal of other serum proteins such as albumin. AGP concentrations in serum of healthy volunteers and patients correlated well with results from the conventional single radial immunodiffusion (SRID) method (r = 0.93, slope = 1). The newly developed method is faster and has a larger analytical concentration range than the SRID method. This method can also be used to determine AGP in serum of experimental animals, and it can serve to monitor AGP serum concentrations for pharmacokinetic evaluation of basic drugs. 相似文献
63.
64.
Finger bougie method compared with pyloroplasty in the gastric replacement of the esophagus 总被引:2,自引:0,他引:2
Yamashita Y Hirai T Mukaida H Yoshimoto A Kuwahara M Inoue H Toge T 《Surgery today》1999,29(2):107-110
To elucidate the necessity of pyloroplasty for the gastric tube through the posterior mediastinum in esophageal surgery, gastric
emptying and duodenogastric reflux (DGR) were evaluated in 16 cases undergoing an anterior pylorectomy (group P) and in 16
cases treated by the finger bougie method (group F). First, the obstruction and reflux symptoms were examined based on a patient
questionnaire using a brief scoring system. The median value of the symptom score showed the patients in P to have more symptoms
than those in F; however, the difference was not significant (8.0 vs 6.0). Secondly, the swallowed Tc O4
− (85 MBq) was counted using a gamma camera at three sites on the sternal bone in the upright position based on a gastric transit
scintigram. Both the descending time of the RI peak and the clearance rates were similar between the two groups. Thirdly,
intragastric 24-h pH monitoring was carried out. Antimony pH sensors were anchored 5 and 15 cm below the esophagogastrostomy.
We could not find any difference between the two groups in both the % time pH>4 and %time pH>7. These findings thus revealed
no big difference between groups P and F. The finger bougie method to drain the vagotomized posterior mediastinal stomach
was found to achieve results similar to conventional pyloroplasty, while it was also simpler and safer. 相似文献
65.
Hirata M Katsumata K Masaki T Koike N Endo K Tsunemi K Ohkawa H Kurokawa K Fukagawa M 《Kidney international》1999,56(6):2040-2047
22-Oxacalcitriol ameliorates high-turnover bone and marked osteitis fibrosa in rats with slowly progressive nephritis. BACKGROUND: 22-Oxacalcitriol (OCT) is a unique vitamin D analogue with less calcemic activity than calcitriol, and it effectively suppresses parathyroid hormone (PTH) secretion in uremic rats. This study was performed to examine the long-term effect of intravenously administered OCT on high-turnover bone disease in model rats of slowly progressive renal failure. METHODS: Slowly progressive renal failure rats were made by a single injection of glycopeptide isolated from rat renal cortical tissues. At 250 days, glycopeptide-induced nephritis (GN) rats were divided into three groups with the same levels of serum creatinine and PTH, and they received either OCT (0.03 or 0.15 microg/kg body wt) or vehicle given intravenously three times per week for 15 weeks. RESULTS: Renal function of GN rats deteriorated very slowly but progressively, as assessed by the increase of serum creatinine concentration. At sacrifice, serum PTH levels, bone formation markers, bone resorption markers, and fibrosis volume were significantly elevated in vehicle-treated GN rats compared with those of sham-operated rats, suggesting the development of high-turnover bone disease with osteitis fibrosa. In contrast, in the GN-OCT 0.15 microg/kg group, these high PTH levels and high-turnover bone and fibrosis were significantly decreased. Such amelioration of bone abnormalities by OCT was not accompanied by either hypercalcemia or further deterioration of renal function. CONCLUSIONS: These data indicate that OCT may be a useful and safe agent not only for the suppression of PTH, but also for the amelioration of osteitis fibrosa and high-turnover bone without causing hypercalcemia in chronic dialysis patients. 相似文献
66.
Shizuo Oi Mitsunori Matsumae Futoshi Takei Masaki Shinoda Osamu Sato Satoshi Matsumoto 《Child's nervous system》1996,12(5):242-247
The process of the development of the intracranial vessels was studied by means of immunohistochemical analysis of factor VIII in normal and exencephalic chick fetuses. The results revealed that the development of blood vessels in exencephalic brain was far advanced beyond the norm, with intense immunoreactivity to factor VIII on postincubation day 16 exceeding that on day 21 in normal controls. Compared with results regarding the direction of the overgrowth in the neuronal maturation process in the previous study using the chick exencephaly model, the findings of overmatured blood vessels were compatible with NSE- and somatostatin-positive elements that appeared especially in the overgrowth foci. The results of the present study suggested the pathogenic development of the area cerebrovasculosa in the neural placode as a phenomenon consequent upon hypervascularization in response to neuronal overgrowth, as seen in human cases of exencephaly or anencephaly. We emphasize the significance of this specific phenomenon in the development of the fetal central nervous system, namely neurovascular developmental interaction. 相似文献
67.
Hirose M Yoda K Sakai K Saitoh A Nakagawa H Tanaka M Miyazaki M 《Journal of anesthesia》1991,5(1):30-35
Prostaglandin E1-induced hypotension (25% reduction from the preadministration level in mean arterial pressure) was applied to thirteen patients. Eight patients among them were operated in the supine position (group I) and other five in the prone position (group II). The maintenance dose of PGE1 was considerably lower in group II than in group I (0.067µg·kg–1·min–1 vs. 0.119µg·kg–1·min–1). In group I, there was a significant increase in CI, with a significant decrease in SVRI and PVRI during PGE1-induced hypotension. Such a high dose of PGE1 (0.119µg·kg–1·min–1) was considered to have a direct dilating action on the systemic resistance bed as well as on the pulmonary vasculature. It was considered that the suppression of hypoxic pulmonary vasoconstriction could be a mechanism to increase venous admixture during PGE1-induced hypotension. In group II, there was no significant increase in CI, and no significant decrease in SVRI and PVRI. PGE1-induced hypotension can be safely applied to the anesthetized patients, but we should be careful to apply it to the patients in the prone position, because lower dose of PGE1 can induce severe hypotension, which is not accompanied by the increase in CI as occures in the patients in the supine position.(Hirose M, Yoda K, Sakai K, et al.: Comparative Study on the cardio-respiratory change during prostaglandin E1-induced hypotention in the patients in the supine and prone position. J Anesth 5: 30–35, 1991) 相似文献
68.
69.
Kouichirou Nishiyama Hajime Hirose Yoshiaki Iguchi Kazuhiro Yamamoto Takashi Masaki Takahiro Kamijo Takeshi Ino Jun Yamanaka Kazuo Yao Makito Okamoto 《Nihon Jibiinkoka Gakkai kaiho》2003,106(3):220-225
To improve low-pitched voices in cases with polypoid vocal cords, YAG laser irradiation combined with a mucosal suturing technique was attempted in 9 female cases with severe polypoid changes in their vocal cords. A YAG laser beam (5 to 10 W) was used to irradiate the upper surface of the polypoid vocal cord. The polypoid content of the cord was gradually coagulated, and the free edge of the cord appeared to slide up toward the burned area. The polypoid content was then removed and squeezed through an open wound made in the burned area using a conventional method. Bleeding was successfully controlled using the laser. After the excessive mucosal margin was trimmed and the contour of the vocal cord was adjusted, the wound was closed by 7-0 monofilament absorbable suture. Suturing was relatively easy because the mucosal edge was also coagulated. Postoperative evaluations of voice quality revealed an improvement in the GRBAS scale of voice quality as well as an elevation in voice pitch and an upwards shift in the voice range in all cases. 相似文献
70.