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121.
Micheline Dsamou Martine Morzel Ludovic Le Corre Isabelle Séverin Marie-Christine Chagnon 《Archives of oral biology》2013,58(10):1511-1516
ObjectiveThe study aimed at evaluating in vitro the effect of caffeine on expression of cystatin SN, a potential marker of sensitivity to bitterness in humans.MethodsDifferentiation of human submandibular gland (HSG) cells was induced by culturing cells on Matrigel. Caffeine cytotoxicity was assessed over 3 days by the Resazurin test. Finally, effects of 5, 50 and 100 μM caffeine exposure on cystatin SN expression were explored over 3 days by ELISA.ResultsAt concentrations relevant to human adult plasma levels (5, 50 and 100 μM), caffeine did not affect cell viability whether cells were differentiated or not. Cystatin SN levels were overall higher in differentiated cells and increased with time in both conditions. There was a significant (p < 0.001) effect of caffeine on cystatin SN expression specifically in differentiated cells.ConclusionsThe HSG cell line proved to be a relevant tool to study in vitro the effect of caffeine at concentrations consistent with dietary intake in human subjects. The results suggest that salivary cystatin SN abundance may depend on caffeine intake, with possible consequences on taste sensitivity. 相似文献
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Daniel Faurholt‐Jepsen Nyagosya Range George PrayGod Kidola Jeremiah Maria Faurholt‐Jepsen Martine G. Aabye John Changalucha Dirk L. Christensen Henrik Krarup Daniel R. Witte Aase B. Andersen Henrik Friis 《Tropical medicine & international health : TM & IH》2012,17(7):877-883
Objective Diabetes is associated with pulmonary tuberculosis (TB), possibly due to impaired immunity, and diabetes may exacerbate the clinical manifestations of TB. Our aim was to assess the role of diabetes in the clinical manifestations of TB. Methods We studied 1250 patients with pulmonary TB in an urban population in a cross‐sectional study in Tanzania. All participants were tested for diabetes and HIV co‐infection, and TB culture intensity was assessed. Levels of white blood cells, haemoglobin, acute phase reactants, CD4 count and HIV viral load were measured, and a qualitative morbidity questionnaire was used to identify the prevalence of disease‐related symptoms. Results Tuberculosis patients with diabetes had a higher neutrophil count (B 0.5 × 109 cells/l, 95% CI 0.2; 0.9, P = 0.001) than non‐diabetic TB patients. Serum C‐reactive protein (B 18.8 mg/l, CI 95% 8.2; 29.4, P = 0.001) and alpha‐1‐acid glycoprotein (B 0.2 g/l, CI 95% 0.03; 0.3, P = 0.02) were similarly higher in patients with diabetes. Diabetes did not affect culture intensity or HIV status, but self‐reported fever was three times higher among participants with diabetes than in those without diabetes (OR 2.9, CI 95% 1.5; 5.7, P = 0.002). Conclusion Diabetes is associated with small changes in the manifestations of TB, but may have little clinical significance. 相似文献
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King LA Nogareda F Weill FX Mariani-Kurkdjian P Loukiadis E Gault G Jourdan-DaSilva N Bingen E Macé M Thevenot D Ong N Castor C No?l H Van Cauteren D Charron M Vaillant V Aldabe B Goulet V Delmas G Couturier E Le Strat Y Combe C Delmas Y Terrier F Vendrely B Rolland P de Valk H 《Clinical infectious diseases》2012,54(11):1588-1594
126.
Agnès Ostertag Corinne Collet Christine Chappard Sylvie Fernandez Eric Vicaut Martine Cohen-Solal Marie-Christine de Vernejoul 《BONE》2013,52(1):48-55
ObjectivesTo determine biochemical, radiological and micro-architectural bone factors related to fragility fractures in idiopathic male osteoporosis (IMO) patients. IMO is a rare disorder characterized by low areal bone mineral density (aBMD) (Z-score < ? 2) occurring in men after excluding secondary causes of low BMD.MethodsWe conducted a case–control study in 31 patients with fragility fracture (IMO F +) that had occurred after the age of 40 years and 37 without fracture (IMO F–). We first compared IMO group to 40 age-matched disease-free men. We measured aBMD and bone micro-architectural indices at distal radius and tibia sites with a HR-pQCT scan (XtremeCT) using standard and extended cortical analysis. Urine and blood samples were collected in order to determine the levels of bone-turnover markers and the potential determinant of bone fragility. Models of analysis of covariance, including age, height and weight as adjustment factors, were used to compare the groups.ResultsCompared to their controls, IMO patients showed marked disturbance of their micro‐architectural parameters at tibia and radius affecting both trabecular and cortical parameters. IMO F + subjects were significantly older than IMO F ? subjects (58 ± 8 vs. 53 ± 9 yrs, p = 0.01). BMD Z-score at the total-hip was significantly lower in IMO F + (? 1.3 ± 0.5 vs. ? 0.9 ± 0.8 g/cm2, p = 0.01). After adjustment, trabecular micro‐architectural parameters, biochemical markers and hormonal parameters were not different in the 2 groups. At distal tibia, cortical v-BMD was significantly lower in IMO F + patients (799 ± 73 vs. 858 ± 60 mg/cm3, p = 0.03), while cortical thickness was not different.ConclusionOur results show that patients with IMO display a marked disturbance of trabecular and cortical bone micro-architecture, and that age and low cortical density are determinants of the fracture occurrence. 相似文献
127.
Guillaume T. Vallet Carol Hudon Martine Simard Rémy Versace 《Cortex; a journal devoted to the study of the nervous system and behavior》2013
Implicit memory is generally supposed to be preserved in Alzheimer’s disease (AD). Yet, some implicit priming effects are impaired and others are not. The preserved/impaired priming effects are often interpreted according to the perceptual/conceptual or identification/production distinctions. Perceptual–identification priming paradigms shall be preserved and conceptual–production priming paradigms impaired. A third interpretation is yet possible based on the disconnection syndrome hypothesis which states that patients with AD should fail tasks requiring relatively complex brain communications. In this case, patients with AD should not demonstrated a significant perceptual priming effect in an identification task if this one involved complex brain communications. The present study tests this latter hypothesis with two cross-modal priming experiments using a categorization task. A visual meaningless mask presented with half of the auditory primes tested the nature of the cross-modal priming effect. The control group exhibited significant priming effects for unmasked primes. The interference effect of the mask demonstrated that the priming effect was perceptually driven. Patients with AD did not present any priming effect nor mask interference. The present findings therefore showed that perceptual priming using an identification task could be impaired in AD supporting the disconnection syndrome hypothesis. 相似文献
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Lucarini Valeria Cangemi Francesco Daniel Benyamin Daniel Lucchese Jacopo Paraboschi Francesca Cattani Chiara Marchesi Carlo Grice Martine Vogeley Kai Tonna Matteo 《European archives of psychiatry and clinical neuroscience》2022,272(6):997-1005
European Archives of Psychiatry and Clinical Neuroscience - Difficulties in interpersonal communication, including conversational skill impairments, are core features of schizophrenia. However,... 相似文献
130.
Marleen Kerste Jellina Corver Martine C. Sonnevelt Monique van Brakel Paul D. van der Linden Babette A. M. Braams-Lisman 《The journal of maternal-fetal & neonatal medicine》2016,29(23):3860-3865
Objective: To compare actual antibiotic use to the stratification based on the sepsis calculator in newborns with suspected early onset sepsis (EOS). To investigate differences in EOS risk and vital signs between newborns that received early (<12?h) versus late antibiotics (≥12?h of life).Methods: Newborns born ≥34 weeks gestation in 2014 treated with antibiotics started within 72?h after birth were included. We calculated the risk per 1000 live births and retrospectively assigned each newborn to one of four recommended categories using the sepsis calculator.Results: There were 2094 newborns, 111 (5.3%) received antibiotics and 108 newborns were included. The incidence of culture-proven EOS was 0.096%. In 57 newborns, the advice of the sepsis calculator was not to start antibiotic therapy. Antibiotic treatment was started early in 66 (61%) and late in 42 (39%) newborns. In the “late treatment” group, clinical condition deteriorated, including two newborns with culture-proven EOS. Tachypnea and respiratory distress were significantly more present.Conclusion: Antibiotic use could be reduced by more than 50%. Newborns with initial low sepsis risk score clinically deteriorated beyond 12?h of life. Continuous good clinical observation remains very important. Prospective validation is necessary to evaluate the safety of this approach. 相似文献