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Hong S Bardwell WA Natarajan L Flatt SW Rock CL Newman VA Madlensky L Mills PJ Dimsdale JE Thomson CA Hajek RA Chilton JA Pierce JP 《Breast cancer research and treatment》2007,103(2):225-232
Background Physical activity levels among breast cancer survivors are typically low, and knowledge of the correlates of increased physical
activity among cancer survivors is limited. The purpose of this study was to examine factors that are associated with physical
activity or inactivity among breast cancer survivors.
Methods Data from 3088 women participating in the Women’s Healthy Eating and Living (WHEL) Study, collected prior to randomization,
were the focus of the current analyses. Self-reports of physical activity levels, quality of life, depression, and dietary
intakes were collected. Pearson correlation analyses were employed to examine the associations among these variables, and
multiple regression analyses were performed to examine the relationship between selected health behaviors and physical activity
levels, after controlling for demographic, breast cancer-related, and psychosocial variables.
Results Demographic and psychosocial variables were related to physical activity levels (P < 0.001 for all). Cancer treatment type and cancer stage were correlated with survivors’ physical activity levels (P < 0.01), but the associations were no longer significant after controlling for demographic variables. Physical activity levels
were strongly associated with other health behaviors, especially dietary intakes (P < 0.001), even after controlling for demographic, cancer-related, and psychosocial factors.
Conclusion Low physical activity levels in breast cancer survivors are associated with specific behavioral and other factors, which can
be considered as indicators of women at higher risk. Findings of significant differences in physical activity levels based
on demographic characteristics suggest the importance of promoting physical activity particularly among breast cancer survivors
of ethnic minority or lower education levels. 相似文献
276.
Pheochromocytoma in MEN 2A Syndrome. Study of 54 Patients 总被引:3,自引:0,他引:3
Rodriguez JM Balsalobre M Ponce JL Ríos A Torregrosa NM Tebar J Parrilla P 《World journal of surgery》2008,32(11):2520-2526
Background Pheochromocytoma occurs in nearly 50% of MEN 2A (multiple endocrine neoplasia, type 2A) cases. Many issues related to this
tumor are still the subject of debate: the diagnostic management in patients who have had positive genetic study results (RET
mutation), variations related to mutation, the best surgical option, and the real relapse rate during long-term follow-up.
The aim of this study is to present our experience with this unusual disease, looking for answers to some of these questions.
Patients and methods Of 169 patients belonging to 19 MEN 2A families, 54 (32%) presented with pheochromocytoma. The following variables have been
studied: (1) clinical and diagnostic data [age, mutation, clinical features, results of catecholamines and catabolites in
a 24-h urine sample, computerized tomography (CT) scan and iodine-131 meta-iodobenzylguanidine (MIBG) scintigraphy results,
and the means of diagnostic, clinical, or genetic screening]; (2) surgical treatment; and (3) follow-up and recurrence. The
mean follow-up time was 92.5 months (range: 12–120 months).
Results The mean age of the 54 patients was 37.9 years (range: 14–71 years); 33 were women. Most (96.3%) mutations were found in exon
11. The most frequent mutations were Cys634Tyr (in 33 cases [61.1%]) and Cys634Arg (in 14 [25.9%]). The diagnosis of pheocromocytoma
was made after the diagnosis of MTC in 26 cases (48.2%), simultaneously in 21 (38.9%), and prior in the 7 remaining cases
(12.9%). At the time of diagnosis 28 patients (51.8%) were asymptomatic and 26 (48.2%) had clinical features related to pheochromocytoma.
In 6 patients (11.1%), the values of catecholamines and catabolites in urine were normal. In the cases with high values, the
most useful isolated determination was that of metanephrines (82%), followed by adrenaline (76%). The CT scan did not provide
a correct diagnosis in 6 patients with bilateral lesions, and one patient with a bilateral tumor was not diagnosed by MIBG.
The combination of CT scan and MIBG diagnosed 100% of cases. The pheochromocytoma was bilateral in 27 cases, with a total
number of 81 pathological glands detected. A laparascopic approach was used in 30 cases and a laparotomy in 24. The mean tumor
size was 4.5 cm (range: 1–18 cm). Five patients with unilateral resection relapsed (18.5%), and the mean relapse time was
43.2 months (range: 12–120 months). There was a greater frequency of pheochromocytoma in those subjects who had the Cys634Arg
mutation (p < 0.03). In addition, the Cys634Arg mutation is more frequent in bilateral cases. There are no prognostic factors for recurrence.
Conclusions Pheochromocytoma in MEN 2A is related to the type of mutation, which can be early onset and is frequently asymptomatic. Its
diagnosis requires catecholamines determinations as well as a CT scan. Correct diagnosis of bilaterality is established by
CT and MIBG. Laparoscopic adrenalectomy is the treatment of choice. 相似文献
277.
Arenas MD Alvarez-Ude F Torregrosa V Gil MT Carretón MA Moledous A Nuñez C Devesa R Albiach B 《Journal of nephrology》2007,20(4):453-461
278.