全文获取类型
收费全文 | 140篇 |
免费 | 9篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 16篇 |
口腔科学 | 2篇 |
临床医学 | 20篇 |
内科学 | 27篇 |
皮肤病学 | 11篇 |
神经病学 | 31篇 |
外科学 | 9篇 |
预防医学 | 9篇 |
眼科学 | 1篇 |
药学 | 13篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 3篇 |
2022年 | 20篇 |
2021年 | 20篇 |
2020年 | 6篇 |
2019年 | 15篇 |
2018年 | 17篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 1篇 |
2014年 | 6篇 |
2013年 | 5篇 |
2012年 | 10篇 |
2011年 | 10篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 3篇 |
2007年 | 1篇 |
2006年 | 3篇 |
2005年 | 1篇 |
2003年 | 1篇 |
2000年 | 3篇 |
1999年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
排序方式: 共有149条查询结果,搜索用时 15 毫秒
31.
Mariem Kharroubi Fatima Bellali Abdelhafid Karrat Mohamed Bouchdoug Abderrahim Jaouad 《AIMS Public Health》2021,8(4):754
This study aimed to formulate sodium lauryl sulfate cross-linked chitosan beads and sodium alginate-chitosan films for designing a dressing that would shorten the healing time of skin wounds. Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads (CH-SLS) and chitosan-alginate (CH-ALG) films were prepared and characterized by using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM). The swelling properties of the CH-SLS beads were also analyzed in a water solution. The obtained Teucrium polium extract-loaded CH-SLS beads and CH-ALG films (TBF) were further incorporated into the commercial adhesive dressing. This TBF wound dressing was then investigated for evaluation of its wound healing potential in the mice using the excision wound model. Healing was assessed by the macroscopic appearance and the rate of wound contraction during 8 days. On day 4, the TBF-treated wounds exhibited 98% reduction in the wound area when they were compared with healing ointment, elastic adhesive dressing, and untreated wounds which were exhibited 63%, 43%, and 32%, respectively. Furthermore, the application of TBF dressing reduced skin wound rank scores and increased the percentage of wounds contraction. These results demonstrate that TBF dressing improves considerably the healing rate and the macroscopic wound appearance at a short delay and this application may have therapeutic benefits in wound healing. 相似文献
32.
Hamdouni Haithem Achour Ons Naija Salma Rejeb Jihène Aounallah Mariam Mhiri Mariem 《The International journal of neuroscience》2018,128(1):32-41
Purpose: Dementia is a multifactorial idiopathic pathology caused by clinical, eDementia is a multifactorial idiopathic pathology caused by clinical, environmental and genetic factors. Hence, its etiology is still unknown. We aimed to evaluate the association between five genetic risk factors for vascular diseases and dementia individually and when gathered in haplotypes. Materials and Method: We enrolled 200 dementia patients and 300 controls. All subjects were genotyped for vascular diseaseassociated polymorphisms in the genes coding for Apolipoprotein-E (ApoE), angiotensin converting enzyme (ACE) and Paraoxonase-1 (PON1). Results: The association between dementia risk and all the studied polymorphisms except of PON1-Q192R was found to be significant. Carrying the ApoE e4 allele seems to increase dementia risk by 4.32 fold (p = 0.001). The risk associated with ACE I and PON1-L55M T alleles were lower (2.58 and 2.11 fold, p < 0.001 and p = 0.015, respectively). When combined in haplotypes, these polymorphisms showed a cumulative and synergetic effect. GTICC haplotype appears to be associated with 9-fold dementia risk (p < 0.001), whereas AADTT seems to reduce dementia risk by 80% (p = 0.003). Conclusion: Our results suggest that, ApoE ε4, ACE I and PON1-L55M T alleles are associated with dementia risk whether these polymorphisms were studied separately or gathered in haplotypes. Still, the contribution of each gene to the pathophysiological development of dementia must be more investigated. 相似文献
33.
34.
Ben Saïd M Ayedi L Mnejja M Hakim B Khalfallah A Charfeddine I Khifagi C Turki K Ayadi H Benzina Z Ghorbel A Castillo ID Masmoudi S Aifa MH 《European journal of medical genetics》2011,54(6):e535-e541
Autosomal recessive non-syndromic hearing loss (ARNSHL) is a genetically heterogenous disorder with 41 genes so far identified. Among these genes, ESRRB whose mutations are responsible for DFNB35 hearing loss in Pakistani and Turkish families. This gene encodes the estrogen-related receptor beta. In this study, we report a novel mutation (p.Y305H) in the ESRRB gene in a Tunisian family with ARNSHL. This mutation was not detected in 100 healthy individuals. Molecular modeling showed that the p.Y305H mutation is likely to alter the conformation of the ligand binding-site by destabilizing the coactivator binding pocket. Interestingly, this ligand-binding domain of the ESRRB protein has been affected in 5 out of 6 mutations causing DFNB35 hearing loss. Using linkage and DHPLC analysis, no more mutations were detected in the ESRRB gene in other 127 Tunisian families with ARNSHL indicating that DFNB35 is most likely to be a rare type of ARNSHL in the Tunisian population. 相似文献
35.
Bensaïd M Hmani-Aifa M Hammami B Tlili A Hakim B Charfeddine I Ayadi H Ghorbel A Castillo ID Masmoudi S 《European journal of medical genetics》2011,54(6):e565-e569
We previously mapped the DFNB66 locus to an interval overlapping the DFNB67 region. Mutations in the LHFPL5 gene were identified as a cause of DFNB67 hearing loss (HL). However, screening of the coding exons of LHFPL5 did not reveal any mutation in the DFNB66 family. The objective of this study was to check whether DFNB66 and DFNB67 are distinctive loci and determining their contribution to HL. In the DFNB66 family, sequencing showed absence of mutations in the untranslated regions and the predicted promoter sequence of LHFPL5. Analysis of five microsatellites in the 6p21.31–22.3 region and screening of the LHFPL5 gene by DNA heteroduplex analysis in DHPLC revealed a novel mutation (c.89dup) in one out of 129 unrelated Tunisian families with autosomal recessive nonsyndromic (ARNS) HL. Our findings suggest that two distinct genes are responsible for DFNB66 and DFNB67 HL. These loci are likely to be a rare cause of ARNSHL. 相似文献
36.
Masmoudi A Boudaya S Charfeddine A Dammak A Amouri M Khabir A Marrekchi S Bouassida S Sallemi T Krichen MS Turki H Zahaf A 《International journal of dermatology》2008,47(2):134-136
Case 1 A 54‐year‐old woman presented with a 5‐month history of an asymptomatic, 2.5‐cm, erythematous, ulcerated nodule involving the umbilicus ( Fig. 1 ). Biopsy demonstrated metastatic adenocarcinoma ( Fig. 2 ) and abdominal ultrasound showed a large ovarian tumor ( Table 1 ). Further evaluation revealed pleural metastases.
37.
Differential impact of consanguineous marriages on autosomal recessive diseases in Tunisia 下载免费PDF全文
Nizar Ben Halim Sana Hsouna Khaled Lasram Insaf Rejeb Asma Walha Faten Talmoudi Habib Messai Ahlem Sabrine Ben Brick Houyem Ouragini Wafa Cherif Majdi Nagara Faten Ben Rhouma Ibtissem Chouchene Farah Ouechtati Yosra Bouyacoub Mariem Ben Rekaya Olfa Messaoud Slim Ben Ammar Leila El Matri Neji Tebib Marie F. Ben Dridi Mourad Mokni Ahlem Amouri Rym Kefi Sonia Abdelhak 《American journal of human biology》2016,28(2):171-180
38.
Henine Sara Rouabhi Rachid Gasmi Salim Amrouche Aml Abide Amna Salmi Aya Toualbia Nadjiba Taib Chahinez Bouteraa Zina Chenikher Hajer Boussekine Samira Kebieche Mohamed Aouimeur Mariem Djabri Belgacem 《Toxicology and Environmental Health Sciences》2016,8(2):161-167
The number of industrial and consumer products which contain engineered nanomaterials (ENMs, materials with at least one dimension 1–100 nm) are increasing exponentially and there is a concern regarding their occupational and environmental safety. Fe3O4 nanoparticles are the most widely used metal oxide nanoparticles especially, in biomedical applications. Although, nanoparticles can enter to the different organs, little is known so far on the toxicity potential and oxidative stress of Fe3O4. Here the understanding of the effect of Fe3O4 nanoparticles on the general Redox state of a unicellular protozoa Paramecium and the effect on mitochondrial swelling and respiration were assessed. Fe3O4 resulted in increase of toxicity markers, lipid peroxidation, protein and ROS formation. Mitochondrial enzymes and swelling were elevated with decreased respiration level. Caspase 3 activity was also increased.Finally, our study suggested that the mitochondrial disease and dysfunction with elevated oxidative stress in Paramecia treated with 200 and 300 ppm during 15 days is the original of toxicity and maybe the original cause of many environmental pathologies. 相似文献
39.
Sarra Melayah Mariem Ghozzi Amani Mankaï Fatma Mechi Ibtissem Ghedira 《Journal of clinical laboratory analysis》2022,36(7)
AimTo determine the frequency of serological markers of RA in patients with anti‐β2 glycoprotein I antibodies (aβ2GPI) of IgA isotype.Material and MethodsA retrospective study was conducted on 67 patients with aβ2GPI‐IgA. Ninety healthy blood donors (HBD) were used as a control group. IgG anti‐cyclic citrullinated peptides antibodies (CCP‐Ab) and rheumatoid factors (RF) IgG, IgA, and IgM were detected by enzyme‐linked immunosorbent assay (ELISA).ResultsSeventeen patients and eight HBD had CCP‐Ab and/or RF (25.4% vs. 8.9%, p = 0.005, CI 95% [14.95; 35.79], odds ratio = 3.5). The frequency of CCP‐Ab was significantly higher in patients than in healthy subjects (14.9% vs. 3.3%, p = 0.009). IgA isotype of RF was significantly higher in patients than in controls (7.5% vs. 0%, p = 0.02). In male patients, CCP‐Ab and/or RF were more frequent than in healthy male subjects (37.5% vs. 11.8%, p = 0.02). In patients, no correlation was found between the levels of aβ2GPI‐IgA and CCP‐Ab (r = 0.082, p = 0.51). There was no correlation between the level aβ2GPI‐IgA and the level of the isotypes of RF (IgG, IgA, and IgM) in patients (r = 0.1, p = 0.37; r = 0.17, p = 0.17 and r = 0.07, p = 0.59 respectively).ConclusionFrequencies of CCP‐Ab and RF are high in patients with aβ2GPI‐IgA suggesting that these patients are susceptible to developing RA. 相似文献
40.
Kouki Chaima Amouri Mariem Bahloul Emna Charfi Slim Hammemi Fatma Boudawara Tahya Turki Hamida 《Clinical Case Reports》2022,10(6)
Panniculitis has various etiologies. One of the less common causes is trauma and hence traumatic fat necrosis (FN). These soft tissue injuries usually appear on the shins, thighs, breasts, arms, and buttocks. FN is mainly caused by trauma and may be associated with other conditions such as pancreatic disease. FN arising after intramuscular injections is uncommon and usually appears as firm, encapsulated, mobile, nontender, and solitary or multiple subcutaneous nodules. We report an interesting case of FN caused by intramuscular injections of cefazolin and meglumine antimoniate (MA) in a 38‐year‐old female patient. MA is regarded as the first‐line systemic treatment for cutaneous leishmaniasis (CL). However, these drugs are not devoid of various potentially adverse reactions. 相似文献