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81.
Clinical activity of ponatinib in one patient with chronic myeloid leukemia in chronic phase with e19a2 transcript and T315I mutation
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Mariana Abdo de Almeida Antonio Vitor Martins Priante Elisangela Manfredini Andraus de Lima Marcia Lanzoni Alvarenga Lira 《Anais brasileiros de dermatologia》2022,97(2):189-192
Bullous melanoma represents a rare variant of melanoma, especially in patients without underlying bullous cutaneous disease. Few cases have been described in the literature, including cases of melanoma in patients with bullous epidermolysis or Hailey-Hailey disease. The histopathological diagnosis of bullous melanoma does not show any difficulties, except for the measurement of the Breslow index. The rarity of this case, the dilemma of how to measure the Breslow index and the importance of an early diagnosis motivated this report. 相似文献
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Sandra M. Blois Flavia Piccioni Nancy Freitag Irene Tirado-González Petra Moschansky Rodrigo Lloyd Karin Hensel-Wiegel Matthias Rose Mariana G. Garcia Laura D. Alaniz Guillermo Mazzolini 《Angiogenesis》2014,17(1):119-128
During liver fibrogenesis the immune response and angiogenesis process are fine-tuned resulting in activation of hepatic stellate cells that produce an excess of extracellular matrix proteins. Dendritic cells (DC) play a central role modulating the liver immunity and have recently been implicated to favour fibrosis regression; although their ability to influence the development of fibrogenesis is unknown. Therefore, we explored whether the depletion of DC during early stages of liver injury has an impact in the development of fibrogenesis. Using the CD11c.DTR transgenic mice, DC were depleted in two experimental models of fibrosis in vivo. The effect of anti-angiogenic therapy was tested during early stages of liver fibrogenesis. DC depletion accelerates the development of fibrosis and as a consequence, the angiogenesis process is boosted. We observed up-regulation of pro-angiogenic factors together with an enhanced vascular endothelial growth factor (VEGF) bioavailability, mainly evidenced by the decrease of anti-angiogenic VEGF receptor 1 (also known as sFlt-1) levels. Interestingly, fibrogenesis process enhanced the expression of Flt-1 on hepatic DC and administration of sFlt-1 was sufficient to abrogate the acceleration of fibrogenesis upon DC depletion. Thus, DC emerge as novel players during the development of liver fibrosis regulating the angiogenesis process and thereby influencing fibrogenesis. 相似文献
86.
Predictors of left ventricular systolic function recovery in the setting of sinus tachycardia in patients with cancer
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Mariana P. Marmorato Núria Pedreño‐Lopez Joana R. Deheinzelin Diogo M. Magnani Varian K. Bailey Priscilla R. Costa Luiz G.F.A.B.D. Zanella Carlos H.V. Moreira Renata Buccheri Vivian I. Avelino‐Silva Natália B. Cerqueira Cássia G.T. Silveira Ho Yeh‐Li David I. Watkins Esper G. Kallás 《The Brazilian journal of infectious diseases》2018
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Betsy Thom Rachel Herring Mariana Bayley Seta Waller Virginia Berridge 《Critical public health》2013,23(1):62-76
Tackling alcohol-related harms crosses agency and professional boundaries, requiring collaboration between health, criminal justice, education and social welfare institutions. It is a key component of most multi-component programmes in the United States, Australia and Europe. Partnership working, already embedded in service delivery structures, is a core mechanism for delivery of the new UK Government Alcohol Strategy. This article reports findings from a study of alcohol partnerships across England. The findings are based on a mix of open discussion interviews with key informants and on semi-structured telephone interviews with 90 professionals with roles in local alcohol partnerships. Interviewees reported the challenges of working within a complex network of interlinked partnerships, often within hierarchies under an umbrella partnership, some of them having a formal duty of partnership. The new alcohol strategy has emerged at a time of extensive reorganisation within health, social care and criminal justice structures. Further development of a partnership model for policy implementation would benefit from consideration of the incompatibility arising from required collaboration and from tensions between institutional and professional cultures. A clearer analysis of which aspects of partnership working provide ‘added value’ is needed. 相似文献