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21.
Mansi IA Opran A Sondhi D Ayinla R Rosner F 《The American journal of the medical sciences》2001,321(3):201-202
We report a 55-year old woman with microscopic polyangiitis who presented with idiopathic pulmonary fibrosis and 1 year later developed hematuria and proteinuria. She had a high serum level of perinuclear anti-neutrophilic cytoplasmic antibodies. Renal angiogram was normal. The diagnosis of microscopic polyangiitis was confirmed by renal biopsy, which showed pauci-immune crescentic glomerulonephritis. The patient received immunosuppressive therapy and improved markedly. Consideration of small vessel vasculitis is important in the differential diagnosis of idiopathic pulmonary fibrosis. 相似文献
22.
Sasso FC Carbonara O Cozzolino D Rambaldi P Mansi L Torella D Gentile S Turco S Torella R Salvatore T 《Journal of the American College of Cardiology》2000,36(1):219-226
OBJECTIVES: The aim of this study was to evaluate: 1) the effects of insulin administration on left ventricular ejection fraction (LVEF) during exercise, and 2) the eventual impairment of the cardiovascular response to insulin in noninsulin dependent diabetes mellitus. BACKGROUND: Insulin influences the cardiovascular system, but its effect on left ventricular function has yet to be established. METHODS: The effects of normal saline (test A) and insulin-glucose (insulin = 1.7 mU x kg(-1) x min(-1); glucose = 6 mg x kg(-1)min(-1)) (test B) infusions on systolic and diastolic functions at rest and during dynamic exercise were examined by radionuclide ventriculography. Twenty-two noninsulin-dependent diabetic patients and 22 gender, age and body mass index matched healthy subjects were investigated. RESULTS: Both groups had normal scintigraphic parameters at rest and during dynamic exercise. Rest- and stress-LVEF as well as rest- and stress-peak filling rate were significantly (p < 0.001) lower in diabetic than in healthy subjects, both in test A and B. Rest-LVEF was significantly higher during test B than it was in test A only in diabetic subjects (p < 0.01). Stress-LVEF was significantly higher (p < 0.05) during test B than it was in test A, in both groups. Insulin-glucose infusion did not modify rest- and stress-peak filling rate in either group. No difference in left ventricular end diastolic volume and in mean blood pressure was found between test A and B at rest and during exercise in either group. A significant linear correlation between LVEF and the index of insulin sensitivity was found in diabetic patients. CONCLUSIONS: In both normal and diabetic humans, insulin induces a very important rise in LVEF after submaximal work. However, the rise is significantly lower in diabetic than in nondiabetic subjects. The increase in exercise-LVEF on insulin is likely due to an enhancement of ventricular contractility. Insulin resistance could justify the lower angioscintigraphic indexes in diabetic subjects. 相似文献
23.
Tripathi Rupal Nathany Shrinidhi Mehta Anurag Batra Ullas Mattoo Sakshi Sharma Mansi 《Clinical and experimental medicine》2021,21(3):439-445
Clinical and Experimental Medicine - Activating mutations in the KRAS gene (Kirsten rat sarcoma 2 viral oncogene homolog gene) are commonly seen across the various solid organ and hematolymphoid... 相似文献
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Objective
To reflect on the challenges of caring for an elderly ill parent who lives afar and to pronounce the importance of system-wide standards in nursing homes and elderly care.Method
Personal memoire in which the author conjures up powerful images of contrasting healthcare systems and the tension of living in two countries.Results
The author discusses many aspects of healthcare for the elderly. Some of the pictures depicted include the picture of a gradually declining memory of an Alzheimer's disease patient and the challenges of elderly care.Conclusion
There is a value of medical knowledge, an importance of nursing homes designs and regulation, and a significance of simple concepts such as a “do-not-resuscitate” order.Practice implications
Care for the elderly can be exhausting physically and emotionally; system-wide changes and standards are important in minimizing its impact. 相似文献29.
L. Mansi E. Daguindau P. Saas F. Pouthier C. Ferrand A. Dormoy I. Patry F. Garnache P.-S. Rohrlich E. Deconinck F. Larosa 《Pathologie-biologie》2014
Hematopoietic cell transplantation (HCT) is a curative treatment for hematological malignancies. This therapeutic approach is associated with a profound immune deficiency and an increased rate of opportunistic infections. Nocardiosis is a rare bacterial infection occurring mainly in patients with deficient cell-mediated immunity, such as AIDS patients or transplant recipients. Diagnosis of nocardiosis can be challenging, as signs and symptoms are non-specific. Routine prophylaxis with trimethoprin/sulfamethoxazole (TMP/SMZ) does not prevent the risk of infection. Between May 2001 and December 2009, five cases of nocardiosis were diagnosed from the 366 allogeneic HCT recipients in our centre. Four patients developed a disseminated nocardiosis within the first year after HCT. The fifth patient presented a localized cutaneous nocardiosis. In disseminated cases, median total CD4+ T-cells were below 100 cells/μL. Naive CD4+ CD45RA+/RO− T-cells were almost undetectable. CD8+ T-cells and NK cells were below the normal range and CD19+ B-cell reconstitution was completely deficient. In a localized case, we observed a lack of naive thymic emigrants CD4+ CD45RA+/RO− T-cells. 相似文献
30.
Surana SP Doddamani S Swaminathan A Mehta MB Zeltser R Vatsia SK Makaryus AN 《Echocardiography (Mount Kisco, N.Y.)》2012,29(4):E102-E104
Approximately 1% of adults who undergo cardiac catheterization have coronary anomalies. Patients may present with chest pain, arrhythmias, presyncope, and sometimes sudden cardiac death. Multidetector computed tomography (MDCT) is an excellent tool for identifying coronary artery anomalies and defining their course and relationship to the great vessels and surrounding structures; its value is incremental to conventional angiography. We present a rare case of a coronary anomaly involving three separate ostia at the right sinus of Valsalva for the left and right coronary vessels. 相似文献