全文获取类型
收费全文 | 947篇 |
免费 | 75篇 |
国内免费 | 63篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 47篇 |
妇产科学 | 4篇 |
基础医学 | 89篇 |
口腔科学 | 24篇 |
临床医学 | 81篇 |
内科学 | 190篇 |
皮肤病学 | 24篇 |
神经病学 | 17篇 |
特种医学 | 258篇 |
外科学 | 40篇 |
综合类 | 62篇 |
预防医学 | 60篇 |
眼科学 | 5篇 |
药学 | 96篇 |
肿瘤学 | 86篇 |
出版年
2023年 | 5篇 |
2022年 | 3篇 |
2021年 | 13篇 |
2020年 | 5篇 |
2019年 | 5篇 |
2018年 | 8篇 |
2017年 | 10篇 |
2016年 | 11篇 |
2015年 | 11篇 |
2014年 | 19篇 |
2013年 | 23篇 |
2012年 | 15篇 |
2011年 | 12篇 |
2010年 | 19篇 |
2009年 | 29篇 |
2008年 | 16篇 |
2007年 | 38篇 |
2006年 | 21篇 |
2005年 | 35篇 |
2004年 | 17篇 |
2003年 | 21篇 |
2002年 | 20篇 |
2001年 | 30篇 |
2000年 | 16篇 |
1999年 | 29篇 |
1998年 | 56篇 |
1997年 | 66篇 |
1996年 | 60篇 |
1995年 | 57篇 |
1994年 | 35篇 |
1993年 | 43篇 |
1992年 | 20篇 |
1991年 | 20篇 |
1990年 | 20篇 |
1989年 | 48篇 |
1988年 | 37篇 |
1987年 | 34篇 |
1986年 | 18篇 |
1985年 | 21篇 |
1984年 | 12篇 |
1983年 | 8篇 |
1982年 | 15篇 |
1981年 | 18篇 |
1980年 | 19篇 |
1979年 | 11篇 |
1978年 | 5篇 |
1977年 | 14篇 |
1976年 | 10篇 |
1975年 | 7篇 |
排序方式: 共有1085条查询结果,搜索用时 109 毫秒
991.
PK PRASHER PP VARMA KV BALIGA SS UPPAL JS SAINI VSM 《Medical Journal Armed Forces India》1999,55(2):126-128
Over a 3 year period from June 94 to June 97, out of 28 patients of systemic lupus, 17 were diagnosed as renal lupus. Demographic data showed 12 females and 5 males, mean age being 32.2 years (range 12 to 54 years). Mean time gap between presentation and definitive diagnosis was 32.4 days (7 days to 5 years). 2 patients (11.76%) presented renal lupus, one (5.88%) with acute interstitial lung disease and the remaining had the usual systemic manifestations of lupus. Anti dsDNA antibodies were positive in all patients while ANA was negative in 3 cases. Renal involvement consisted of rapidly progressive glomerulonephritis in 2 patients (11.76%), nephrotic syndrome in 4 (23.52%) and non nephrotic range proteinuria in 11 (64.70%) patients. Mean serum creatinine at presentation was 2.4mg/dl (0.8mg/dl to 8.9 mg/dl). Three patients were dialysis dependent. Renal histology on light microscopy comprised of class II lesions in one (5.88%), class III in 4 (23.52%), class IV in 11 (64.70%-including one with crescents) and class V in one (5.88%) patient. All patients with advanced class III/IV lesions were treated with corticosteroids and cyclophosphamide pulses. Except one patient who died of pyopericardium all others improved and their serum creatinine stabilised around 2.3 mg/dl (0.8 to 4.6 mg/dl). The study highlights the importance of early diagnosis and aggressive management in this potentially treatable disease.KEY WORDS: Lupus nephritis, Pulse cyclophosphamide 相似文献
992.
993.
Mark?JS?MillerEmail author Brian?K?Reuter John?L?Wallace Keith?A?Sharkey 《Journal of translational medicine》2008,6(1):3
Background
We examined the therapeutic potential of a proprietary Croton palanostigma extract (Zangrado®) in the management of emesis and itch.Methods
Emesis was induced in ferrets with morphine-6-glucuronide (0.05 mg/kg sc) in the presence of Zangrado (3 mg/kg, ip) and the cannabinoid receptor 1 antagonist, AM 251 (5 mg/kg, ip). Topical Zangrado (1%) was assessed for anti-pruretic actions in the 5-HT-induced scratching model in rats and evaluated in capsaicin-induced gastric hyperemia as measured by laser doppler flow. In the Apc Min mouse model of precancerous adenomatosis polyposis, mice received Zangrado (100 μg/ml in drinking water) from the age of 6 – 16 weeks for effects on polyp number. In RAW 264.7 cells Zangrado was examined for effects on lipopolysaccharide-induced nitrite production.Results
Zangrado was a highly effective anti-emetic, reducing morphine-induced vomiting and retching by 77%. These benefits were not associated with sedation or hypothermia and were not reversed by cannabinoid receptor antagonism. Itch responses were blocked in both the morphine and 5-HT models. Zangrado did not exacerbate the Apc Min condition rather health was improved. Capsaicin-induced hyperemia was blocked by Zangrado, which also attenuated the production of nitric oxide by activated macrophages.Conclusion
Zangrado is an effective anti-emetic and anti-itch therapy that is devoid of common side-effects, cannabinoid-independent and broadly suppresses sensory afferent nerve activation. This complementary medicine represents a promising new approach to the management of nausea, itch and irritable bowel syndrome.994.
S Handa JS Bingham 《Journal of the European Academy of Dermatology and Venereology》2001,15(5):430-432
Dermatological conditions are often an early clue to HIV infection and are common. As the disease progresses patients develop a dominant Th-2 immunological response that may facilitate the development of a number of skin conditions. With antiretroviral therapy the Th-1 response is restored and some skin problems regress. But, paradoxically, some cutaneous conditions may worsen, such as herpes zoster, mucocutaneous herpes, eosinophilic folliculitis and mycobacterial infections. This may be because immune restoration of a host's immunity causes recognition of silent or latent infection and results in development of the condition. 相似文献
995.
996.
997.
L Gan LL von Moltke LA Trepanier JS Harmatz DJ Greenblatt MH Court 《Drug metabolism and disposition》2009,37(1):90-96
NADPH-cytochrome P450 reductase (CPR) and cytochrome-b(5) (b(5)) together with NADH-b(5) reductase (b(5)R) play important roles in cytochrome P450 3A-mediated drug metabolism via electron transfer. However, it is not clear whether variability in expression of these accessory proteins contributes to the known interindividual variability in CYP3A activity. CPR and b(5) were measured in human liver microsomes (HLMs) by spectrophotometry and immunoblotting. HLMs from elderly (>or=46 years) male donors (n=11) averaged 27% (P=0.034) and 41% (P=0.011) lower CPR levels than young (相似文献
998.
Children with Attention Deficit/Hyperactivity Disorder (ADHD) often perform poorly on tasks requiring sustained and systematic
attention to stimuli for extended periods of time. The current paper tested the hypothesis that such deficits are the result
of observable abnormalities in search behaviour (e.g., attention-onset, -duration and -sequencing), and therefore can be explained
without reference to deficits in non-observable (i.e., cognitive) processes. Forty boys (20 ADHD and 20 controls) performed
a computer-based complex discrimination task adapted from the Matching Familiar Figures Task with four different fixed search
interval lengths (5-, 10-, 15- and 20-s). Children with ADHD identified fewer targets than controls (p < 0.001), initiated searches later, spent less time attending to stimuli, and searched in a less intensive and less systematic
way (p's < 0.05). There were significant univariate associations between ADHD, task performance and search behaviour. However, there
was no support for the hypothesis that abnormalities in search carried the effect of ADHD on performance. The pattern of results
in fact suggested that abnormal attending during testing is a statistical marker, rather than a mediator, of ADHD performance
deficits. The results confirm the importance of examining covert processes, as well as behavioural abnormalities when trying
to understand the psychopathophyiology of ADHD. 相似文献
999.
1000.
Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine 总被引:2,自引:0,他引:2
The clinically approved cytoprotector amifostine, designated WR-2721,
[S-2-(3-aminopropylamino)ethylphosphorothioic acid], protects against both
radiation and drug-induced mutagenesis in animal systems. These effects
extend over a wide concentration range making amifostine a strong candidate
for evaluation as a possible cancer chemopreventive agent. To better
identify and develop potential intermediate biomarkers for chemoprevention
at the molecular level we applied the technique of differential display
RT-PCR to assess the effects of both the thiol (SH), i.e. WR1065 and the
disulfide (SS), i.e. WR-33278, metabolites of amifostine on gene expression
in CHO-AA8 cells. Cells were exposed to either 40 microM or 4 mM of each
agent for 30 min, and subsequent changes in gene expression were identified
and contrasted to that found in corresponding untreated control cells. One
band that showed a differential response was sequenced and was found to
have 78% homology with a segment of the human pHL-1 cDNA clone contained in
GenBank. This clone contains a COX III mitochondrial DNA insert and two
exons of human c-myc. Northern blot analyses were performed by using the
cloned human c-myc exon 1 probe to confirm whether c-myc gene expression
was affected. Repression of c-myc expression was observed under all of the
conditions evaluated. An exposure of cells to 40 microM of the disulfide
form of amifostine was the most effective in repressing c- myc, i.e. 27% of
control level. A concentration of 4 mM of the disulfide form reduced gene
expression to 45% of the control level, while the thiol form was less
effective, with 4 mM and 40 microM concentrations reducing c-myc gene
expression to 65% and 46% of control levels, respectively.
相似文献