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91.
Kurt Fehr Magda Velvart Monika Rauber Margrit Knpfel Antonio Baici Prathima Salgam Albert Bni 《Arthritis \u0026amp; Rheumatology》1981,24(3):510-519
Immunohistochemical studies were performed in synovial tissues from 40 patients with rheumatoid arthritis (RA), 9 with juvenile rheumatoid arthritis (JRA), 7 with psoriatic arthritis, and 4 with various rheumatic diseases. Overall synthesis of IgG– and/or IgM–rheumatoid factor (RF) was found in all patients with seropositive RA and JRA, in 75% of patients with seronegative RA, and in 1 patient with psoriatic arthritis. Agglutinator producing cells were found in 77% of the samples from seropositive RA and in 44% and 56% from seronegative RA and JRA patients, respectively. The percentage of IgG plasma cells synthesizing one or more of the 5 types of agglutinators studied was approximately 10% of plasma cells synthesizing IgG–RF. Intercellular and intracellular immune complex deposits were also found in patients with seropositive and seronegative RA and JRA. These findings suggest that synthesis of agglutinators by synovial tissue plasma cells of RA and JRA patients is a distinct—but definitely less prominent—function than that of RF synthesis. 相似文献
92.
Test‐retest reliability of the default mode network in a multi‐centric fMRI study of healthy elderly: Effects of data‐driven physiological noise correction techniques 下载免费PDF全文
Rocco Marchitelli Ludovico Minati Moira Marizzoni Beatriz Bosch David Bartrés‐Faz Bernhard W. Müller Jens Wiltfang Ute Fiedler Luca Roccatagliata Agnese Picco Flavio Nobili Oliver Blin Stephanie Bombois Renaud Lopes Régis Bordet Julien Sein Jean‐Philippe Ranjeva Mira Didic Hélène Gros‐Dagnac Pierre Payoux Giada Zoccatelli Franco Alessandrini Alberto Beltramello Núria Bargalló Antonio Ferretti Massimo Caulo Marco Aiello Carlo Cavaliere Andrea Soricelli Lucilla Parnetti Roberto Tarducci Piero Floridi Magda Tsolaki Manos Constantinidis Antonios Drevelegas Paolo Maria Rossini Camillo Marra Peter Schönknecht Tilman Hensch Karl‐Titus Hoffmann Joost P. Kuijer Pieter Jelle Visser Frederik Barkhof Jorge Jovicich 《Human brain mapping》2016,37(6):2114-2132
Understanding how to reduce the influence of physiological noise in resting state fMRI data is important for the interpretation of functional brain connectivity. Limited data is currently available to assess the performance of physiological noise correction techniques, in particular when evaluating longitudinal changes in the default mode network (DMN) of healthy elderly participants. In this 3T harmonized multisite fMRI study, we investigated how different retrospective physiological noise correction (rPNC) methods influence the within‐site test‐retest reliability and the across‐site reproducibility consistency of DMN‐derived measurements across 13 MRI sites. Elderly participants were scanned twice at least a week apart (five participants per site). The rPNC methods were: none (NPC), Tissue‐based regression, PESTICA and FSL‐FIX. The DMN at the single subject level was robustly identified using ICA methods in all rPNC conditions. The methods significantly affected the mean z‐scores and, albeit less markedly, the cluster‐size in the DMN; in particular, FSL‐FIX tended to increase the DMN z‐scores compared to others. Within‐site test‐retest reliability was consistent across sites, with no differences across rPNC methods. The absolute percent errors were in the range of 5–11% for DMN z‐scores and cluster‐size reliability. DMN pattern overlap was in the range 60–65%. In particular, no rPNC method showed a significant reliability improvement relative to NPC. However, FSL‐FIX and Tissue‐based physiological correction methods showed both similar and significant improvements of reproducibility consistency across the consortium (ICC = 0.67) for the DMN z‐scores relative to NPC. Overall these findings support the use of rPNC methods like tissue‐based or FSL‐FIX to characterize multisite longitudinal changes of intrinsic functional connectivity. Hum Brain Mapp 37:2114–2132, 2016. © 2016 Wiley Periodicals, Inc. 相似文献
93.
94.
David Jochheim Marco Barbanti Giuliana Capretti Giulio G. Stefanini Alexander Hapfelmeier Magda Zadrozny Moritz Baquet Julius Fischer Hans Theiss Denise Todaro Alaide Chieffo Patrizia Presbitero Antonio Colombo Steffen Massberg Corrado Tamburino Julinda Mehilli 《JACC: Cardiovascular Interventions》2019,12(16):1566-1576
ObjectivesThe purpose of the study was to investigate the impact of oral anticoagulation (OAC) type on clinical outcomes 1 year after transcatheter aortic valve replacement (TAVR).BackgroundNon–vitamin K oral anticoagulants (NOACs) are superior to vitamin K antagonists (VKAs) in nonvalvular atrial fibrillation (AF), while their comparative performance among patients in need of OAC undergoing TAVR is underinvestigated.MethodsThe study enrolled 962 consecutive patients who underwent TAVR in 4 tertiary European centers and were discharged on either NOACs (n = 326) or VKAs (n = 636). By using propensity scores for inverse probability of treatment weighting (IPTW), the comparison of treatment groups was adjusted to correct for potential confounding.ResultsMean age and Society of Thoracic Surgeons score of the population were 81.3 ± 6.3 years and 4.5% (interquartile range: 3.0% to 7.3%); 52.5% were women and a balloon-expandable valve was used in 62.7% of cases. The primary outcome of interest, combined incidence of all-cause mortality, myocardial infarction, and any cerebrovascular event at 1-year after TAVR, was 21.2% with NOACs versus 15.0% with VKAs (hazard ratio [HR]: 1.44; 95% confidence interval [CI]: 1.00 to 2.07; p = 0.050, IPTW-adjusted). The 1-year incidence of any Bleeding Academic Research Consortium bleeds and all-cause mortality were comparable between the NOAC and VKA groups, 33.9% versus 34.1% (HR: 0.97; 95% CI: 0.74 to 1.26; p = 0.838, IPTW-adjusted) and 16.5% versus 12.2% (HR: 1.36; 95% CI: 0.90 to 2.06; p = 0.136, IPTW-adjusted), respectively.ConclusionsChronic use of both NOACs and VKAs among patients in need of OAC after TAVR are comparable regarding 1-year bleeding risk. The higher ischemic event rate observed with NOACs needs to be evaluated in large randomized trials. 相似文献
95.
Interobserver reproducibility and agreement with original diagnosis in the categories “atypical” and “suspicious for malignancy” for bile and pancreatic duct brushings 下载免费PDF全文
96.
Barry L. Gruber Lee D. Kaufman Mary J. Marchese William Roth Allen P. Kaplan 《Arthritis \u0026amp; Rheumatology》1988,31(8):1000-1006
IgG and IgM autoantibodies directed against IgE were determined in 95 serum samples from 67 patients with systemic lupus erythematosus, by an enzyme-linked immunosorbent assay. IgM anti-IgE autoantibodies were found in 18 patients (27%) and IgG anti-IgE autoantibodies were detected in 23 patients (34%). The specificity of the immunoassay was confirmed by the ability to inhibit binding with IgE myeloma, but not other immunoglobulin isotypes and the demonstration that the reactivity was directed to the Fc ε fragment of IgE. The IgG fraction of certain sera with anti-IgE activity was capable of inducing histamine release from control basophils and cutaneous mast cells. Clinical associations with the presence of anti-IgE activity were sought by retrospective chart analysis of 61 patients. Significant correlation was found with articular involvement, lymphadenopathy, and anti-DNA antibodies (P < 0.05). Anti-IgE autoantibodies are observed in a significant number of patients with systemic lupus erythematosus and may contribute to the pathogenesis of the vascular and articular lesions characteristic of this disease. 相似文献
97.
This is a retrospective chart review of perinatal outcomes of all primiparas over the age of 24 delivering at Maternity Center Associates, an out-of-hospital birth center, from January 1985 through May 1988 (N = 228). Chi-square analysis was used to determine whether mature primiparas, aged 35 to 43 (n = 27), had significantly more adverse outcomes than younger primiparas, aged 25 to 34 (n = 201). There was a significant difference between the groups in rate of transfer to hospital; however, there were no significant differences in rate of cesarean section, infant birth weight, apgar scores, and length of second stage labor. Implications for practice and future study are examined. 相似文献
98.
99.
Lombardi CP Raffaelli M D'alatri L De Crea C Marchese MR Maccora D Paludetti G Bellantone R 《World journal of surgery》2008,32(5):693-700
Background Voice and swallowing symptoms are frequently reported after thyroidectomy even in absence of objective voice alterations.
We evaluated the influence of the video-assisted approach on voice and swallowing outcome of thyroidectomy.
Methods Sixty-five patients undergoing total thyroidectomy (TT) were recruited. Eligibility criteria were: nodule size ≤30 mm, thyroid
volume ≤30 ml, no previous neck surgery. Exclusion criteria were: younger than aged 18 years and older than aged 75 years,
vocal fold paralysis, history of voice, laryngeal or pulmonary diseases, malignancy other than papillary thyroid carcinoma.
Patients were randomized for video-assisted (VAT) or conventional (CT) thyroidectomy. Videostrobolaryngoscopy (VSL), acoustic
voice analysis (AVA), and maximum phonation time (MPT) evaluation were performed preoperatively and 3 months after TT. Subjective
evaluation of voice (voice impairment score = VIS) and swallowing (swallowing impairment score = SIS) were obtained preoperatively,
1 week, 1 month, and 3 months after TT.
Results Fifty-three patients completed the postoperative evaluation: 29 in the VAT group, and 24 in the CT group. No laryngeal nerves
injury was shown at postoperative VSL. Mean postoperative MPT, F
0, F
low, F
high, and the number of semitones were significantly reduced in the CT group but not in the VAT group. Mean VIS 3 months after
surgery was significantly higher than preoperatively in CT group but not in the VAT group. Mean SIS was significantly decreased
1 and 3 months after VAT but not after CT.
Conclusions The incidence and the severity of early voice and swallowing postthyroidectomy symptoms are significantly reduced in patients
who undergo VAT compared with conventional surgery.
Presented at the ISW2007—IAES free paper session, Montreal, Canada, August 26–30, 2007. 相似文献
100.
Jose Lopez-Sendon Peter Mills Heinz Weber Rolf Michels Carlo Di Mario Gerasimos S Filippatos Magda Heras Kevin Fox Jose Merino D J Pennell Heinz Sochor Joanna Ortoli Andras Szatmari Fausto Pinto Jan Peder Amlie Ali Oto Mitja Lainscak Kim Fox Peter Kearney Lino Gon?alves Heikki Huikuri Celine Carrera 《European heart journal》2007,28(17):2163-2171