全文获取类型
收费全文 | 61009篇 |
免费 | 5278篇 |
国内免费 | 4059篇 |
专业分类
耳鼻咽喉 | 520篇 |
儿科学 | 827篇 |
妇产科学 | 1070篇 |
基础医学 | 7767篇 |
口腔科学 | 995篇 |
临床医学 | 7794篇 |
内科学 | 9554篇 |
皮肤病学 | 713篇 |
神经病学 | 3620篇 |
特种医学 | 2348篇 |
外国民族医学 | 52篇 |
外科学 | 6188篇 |
综合类 | 8119篇 |
现状与发展 | 19篇 |
一般理论 | 3篇 |
预防医学 | 4084篇 |
眼科学 | 1675篇 |
药学 | 6389篇 |
62篇 | |
中国医学 | 2997篇 |
肿瘤学 | 5550篇 |
出版年
2024年 | 172篇 |
2023年 | 928篇 |
2022年 | 2369篇 |
2021年 | 3106篇 |
2020年 | 2238篇 |
2019年 | 2112篇 |
2018年 | 2234篇 |
2017年 | 1877篇 |
2016年 | 1878篇 |
2015年 | 2689篇 |
2014年 | 3331篇 |
2013年 | 2825篇 |
2012年 | 4422篇 |
2011年 | 4903篇 |
2010年 | 2975篇 |
2009年 | 2273篇 |
2008年 | 3117篇 |
2007年 | 3177篇 |
2006年 | 3177篇 |
2005年 | 3134篇 |
2004年 | 2150篇 |
2003年 | 2077篇 |
2002年 | 1789篇 |
2001年 | 1256篇 |
2000年 | 1322篇 |
1999年 | 1416篇 |
1998年 | 961篇 |
1997年 | 912篇 |
1996年 | 711篇 |
1995年 | 637篇 |
1994年 | 521篇 |
1993年 | 350篇 |
1992年 | 423篇 |
1991年 | 373篇 |
1990年 | 330篇 |
1989年 | 305篇 |
1988年 | 304篇 |
1987年 | 253篇 |
1986年 | 242篇 |
1985年 | 192篇 |
1984年 | 136篇 |
1983年 | 103篇 |
1982年 | 59篇 |
1981年 | 57篇 |
1980年 | 50篇 |
1979年 | 100篇 |
1978年 | 44篇 |
1977年 | 32篇 |
1975年 | 45篇 |
1974年 | 52篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
131.
无症状性炎性前列腺炎对血清PSA、fPSA的影响 总被引:3,自引:0,他引:3
目的 探讨无症状性炎性前列腺炎(NIH分类Ⅳ型)对血清PSA、fPSA的影响。方法 对比分析36例NIH分类Ⅳ型、42 例有症状性慢性前列腺炎(NIH分类ⅢA型)患者以及22例健康对照组的血清PSA、fPSA、fPSA/tPSA之间的差异。结果 血 清PSA、fPSA、fPSA/tPSA在Ⅳ型和ⅢA型前列腺炎患者间差异无显著性(P>0.05),但与正常对照组比较差异有显著性(P< 0.01)。结论 NIH分类Ⅳ型前列腺炎可引起血清PSA、fPSA升高。对无症状、高血清PSA患者行前列腺活检前,应考虑到患 Ⅳ型前列腺炎的可能。 相似文献
132.
Liang Ma Piergiorgio Tozzi Christoph H Huber Steven Taub Gabrielle Gerelle Ludwig K von Segesser 《European journal of cardio-thoracic surgery》2005,28(2):194-8; discussion 198-9
OBJECTIVE: An animal model has been designed to assess the feasibility of off-pump mitral valve replacement using valved stents. METHODS: Glutaraldehyde-preserved homograft was sutured inside a prosthetic tube (Dacron). Then, two self-expandable nitinol Z-stents were sutured on the external surface of the prosthesis in such a way to create two self-expanding crowns for fixation. In adult pigs and under general anesthesia, the left atrium was exposed through a left thoracotomy and atrio-ventricular roadmapping was performed with intravascular ultrasound (IVUS) and fluoroscopy. The double-crowned valved stents were loaded into a delivery sheath. The sheath was then introduced into the left atrium and the valved stents was deployed in mitral position in such a way that the part in between the two stents was at the level of the mitral annulus. Intracardiac Unltrasound (ICUS) was used to assess the valve function. Hemodynamic parameters were gathered as well. Animal survived for no more than 3h after the valve deployment and gross anatomy examination of the left heart was carried out. RESULTS: The mean height of the valved stents was 29.4+/-0.2 mm, with an internal diameter of 20.4+/-1.0mm, and an external diameter of 25.5+/-0.8 mm. The procedure was successfully carried out in eight animals. In vivo evaluation showed a native mitral annulus diameter of 24.9+/-0.6 mm, and a mean mitral valve area of 421.4+/-17.5 mm2. ICUS showed a mild mitral regurgitation in three out of eight animals. Mean pressure gradient across the valved stents was 2.6+/-3.1 mmHg. Mean pressure gradient across the left ventricular outflow tract (LVOT) was 6.6+/-5.2 mmHg. The mean survival time was 97.5+/-56.3 min (survival time range was 40-180 min). One animal died due to the occlusion of the LVOT because of valved stents displacement. Postmortem evaluation confirmed correct positioning of the valved stent in the mitral position in seven out of eight animals. No atrial or ventricular lesions due to the valved stents were found. CONCLUSIONS: Off-pump implantation of a self-expandable valved stent in the mitral position is technically feasible. Further studies will assess if this procedure is also feasible in humans. 相似文献
133.
Z. Peng Q. Liu Q. Wang E. Rector Y. Ma R. Warrington 《Clinical and experimental allergy》2007,37(7):1040-1048
BACKGROUND: Immunotherapy with anti-IgE antibodies for treatment of allergy is promising but a short half-life and extremely high cost limit its application. OBJECTIVE: We sought to develop IgE vaccines that induce longer-lasting auto-antibodies to neutralize self-IgE as an alternative therapy. METHODS: The vaccine was made by conjugating three synthetic peptides corresponding to human IgE receptor-binding sites to a carrier, hepatitis B surface antigen. To test the immunogenicity of the vaccine, rats were immunized with the vaccine or hepatitis B surface antigen as control. Serum IgG titres to human IgE and the IgE of other species were measured. The inhibition by rat antisera of the binding of human IgE to its receptor was assessed by ELISA, flow cytometry analysis, and passive cutaneous anaphylaxis (PCA), and its ability to recognize receptor-bound IgE was examined. The in vivo effect of the vaccine was evaluated in trichosanthin-sensitized mice and rats. In the preventative study, vaccination started before sensitization commenced, while in the treatment study, vaccination started after sensitization. Sensitized mice and rats receiving injections of the carrier served as controls. Trichosanthin-specific IgE was measured using PCA. RESULTS: Sera from vaccine-immunized rats contained high titre antibodies that reacted with soluble and plate-bound but not with receptor-bound human IgE; they also reacted with mouse, rat, and dog IgE. Furthermore, the sera inhibited the binding of human IgE to its receptor in a dose-dependent manner. In preventative and treatment studies, serum trichosanthin-specific IgE levels were significantly reduced in vaccinated groups compared with controls. CONCLUSION: Antibodies against self-IgE can be induced by IgE peptide-based vaccines, which are effective in preventing the increase of IgE and in down-regulating IgE in sensitized animals. 相似文献
134.
135.
Using a two‐stage global scan design, we analyzed general population replicates 1 and 42 of the Genetic Analysis Workshop (GAW) 12 simulated data set using three methods: revisited Haseman‐Elston (HER), maximum likelihood variance estimation (ML), and variance components (VC). Three marker densities, 5‐, 10‐, and 15‐cM intervals, were examined in the first‐stage scan. We found that the 10‐cM interval appears to be the most cost‐effective approach in genotyping without sacrificing power when using a first stage significance level of 0.01. Subsequently, we performed the second‐stage scan at 1‐cM intervals for those putative positive regions identified in the first‐stage scan at a significance level of 0.01. We also compared the power to detect linkage using different numbers of sib pairs for a genome‐wide scan at a 10‐cM interval and found that power decreases nonlinearly as the number of sib pairs decreases. © 2001 Wiley‐Liss, Inc. 相似文献
136.
33例肝占位性病变MRI误诊的分析 总被引:1,自引:0,他引:1
我院1988年以来4000余例腹部MRI中,发现肝占位性病变误诊33例。所用机型为美国Disonics公司0.5T超导MRI,自旋回波序列(SE序列)、常规T1加权(T1WI)、质子加权(PDWI)、T2加权(T2WI),覆盖全肝。其中,PHC误诊为MHC5例、MHC误诊为PHC6例、PHC误为HHE5例、MHC误诊为HHE2例、HHE误诊为PHC6例、肝硬化结节误诊为PHC2例、炎性假瘤误诊为PHC3例、肝结核误诊为PHC1例、HCY误诊为HHE3例。本文从病变的影像学特征和扫描技术方面详细探讨了误诊的原因和鉴别诊断要点。 相似文献
137.
本文报告了2,4,6-三硝基甲苯(TNT)的代谢物,2-氨基-4,6-二硝基甲苯2和2,4-二氨基-6-硝基甲苯3的合成。以邻甲基苯甲酸为原料,经硝化(HNO_3-H_2SO_4)和Schmidt反应(NaN_3-H_2SO_4)得到2,用NaHS还原TNT的方法合成化合物3。 相似文献
138.
本文对我科于1986年元月~8月收治的100例乳腺增生病人的临床诊断进行了研究。100例病人全部做了细针吸取活检及细胞学检查,轻度增生71例,中度增生13例,重度增生16例。细针吸取活检简单、方便,是乳腺增生症诊断的一种重要方法。 相似文献
139.
140.
O. John Ma MD Michael P. Kefer MD James R. Mateer MD RDMS Beth Thoma MD 《Academic emergency medicine》1995,2(7):581-586
Objective: To compare the sensitivities, specificities, and accuracies between a single-view ultrasonography (US) technique and a multiple-view technique for identifying hemoperitoneum in multiple-trauma patients.
Methods: Data from a prior prospective study of US for trauma diagnosis at a level I trauma center were retrospectively analyzed. A convenience sample of adult patients (≥ 18 years of age) who had presented with major blunt or penetrating torso trauma and had undergone rapid trauma US examinations to detect hemoperitoneum were reviewed. The US interpretations by emergency physicians had been recorded prior to obtaining other diagnostic tests. Five views were evaluated, including the right intercostal oblique view examining Morison's pouch. Evidence of free intraperitoneal fluid by exploratory laparotomy, CT, or diagnostic peritoneal lavage (DPL) was used as the criterion standard.
Results: Of the 245 patients entered into the study, 37 had free intraperitoneal fluid, confirmed by CT, DPL, or exploratory laparotomy. With the multiple-view technique, US was 87% (95% CI = 71%, 96%) sensitive, 100% (95% CI = 97%, 100%) specific, and 98% (95% CI = 95%, 100%) accurate. The single-view technique, evaluating only Morison's pouch, was 51% (95% CI = 34%, 68%) sensitive, 100% (95% CI = 98%, 100%) specific, and 93% (95%. CI = 89%, 96%) accurate.
Conclusions: An initial trauma US examination using a multiple-view technique is more sensitive than that using a single-view technique for detecting hemoperitoneum in trauma patients. 相似文献
Methods: Data from a prior prospective study of US for trauma diagnosis at a level I trauma center were retrospectively analyzed. A convenience sample of adult patients (≥ 18 years of age) who had presented with major blunt or penetrating torso trauma and had undergone rapid trauma US examinations to detect hemoperitoneum were reviewed. The US interpretations by emergency physicians had been recorded prior to obtaining other diagnostic tests. Five views were evaluated, including the right intercostal oblique view examining Morison's pouch. Evidence of free intraperitoneal fluid by exploratory laparotomy, CT, or diagnostic peritoneal lavage (DPL) was used as the criterion standard.
Results: Of the 245 patients entered into the study, 37 had free intraperitoneal fluid, confirmed by CT, DPL, or exploratory laparotomy. With the multiple-view technique, US was 87% (95% CI = 71%, 96%) sensitive, 100% (95% CI = 97%, 100%) specific, and 98% (95% CI = 95%, 100%) accurate. The single-view technique, evaluating only Morison's pouch, was 51% (95% CI = 34%, 68%) sensitive, 100% (95% CI = 98%, 100%) specific, and 93% (95%. CI = 89%, 96%) accurate.
Conclusions: An initial trauma US examination using a multiple-view technique is more sensitive than that using a single-view technique for detecting hemoperitoneum in trauma patients. 相似文献