全文获取类型
收费全文 | 3704篇 |
免费 | 216篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 97篇 |
妇产科学 | 93篇 |
基础医学 | 499篇 |
口腔科学 | 91篇 |
临床医学 | 237篇 |
内科学 | 1209篇 |
皮肤病学 | 76篇 |
神经病学 | 224篇 |
特种医学 | 169篇 |
外科学 | 525篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 131篇 |
眼科学 | 17篇 |
药学 | 188篇 |
中国医学 | 7篇 |
肿瘤学 | 328篇 |
出版年
2023年 | 26篇 |
2022年 | 46篇 |
2021年 | 83篇 |
2020年 | 43篇 |
2019年 | 73篇 |
2018年 | 76篇 |
2017年 | 66篇 |
2016年 | 59篇 |
2015年 | 66篇 |
2014年 | 98篇 |
2013年 | 115篇 |
2012年 | 206篇 |
2011年 | 213篇 |
2010年 | 108篇 |
2009年 | 101篇 |
2008年 | 194篇 |
2007年 | 180篇 |
2006年 | 177篇 |
2005年 | 207篇 |
2004年 | 212篇 |
2003年 | 147篇 |
2002年 | 164篇 |
2001年 | 147篇 |
2000年 | 122篇 |
1999年 | 108篇 |
1998年 | 42篇 |
1997年 | 34篇 |
1996年 | 32篇 |
1995年 | 32篇 |
1994年 | 32篇 |
1993年 | 28篇 |
1992年 | 73篇 |
1991年 | 78篇 |
1990年 | 60篇 |
1989年 | 60篇 |
1988年 | 47篇 |
1987年 | 44篇 |
1986年 | 41篇 |
1985年 | 34篇 |
1984年 | 36篇 |
1983年 | 39篇 |
1982年 | 24篇 |
1980年 | 12篇 |
1979年 | 29篇 |
1978年 | 13篇 |
1976年 | 14篇 |
1975年 | 15篇 |
1974年 | 9篇 |
1972年 | 10篇 |
1967年 | 11篇 |
排序方式: 共有3930条查询结果,搜索用时 15 毫秒
71.
72.
Celestino Pio Lombardi Marco Raffaelli Carmela De Crea Luca Sessa Rocco Bellantone 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2014,399(6):747-753
Purpose
Complication rate in reoperative central neck node surgery is one of the main arguments to favor prophylactic central neck dissection at first operation in patients with papillary thyroid carcinoma. We evaluated if reoperative central neck dissection implies an increased postoperative morbidity. Secondarily, we aimed also to verify the effectiveness of the surgical resection of reoperative central neck dissection.Methods
Forty-one patients who underwent reoperative central neck dissection after initial thyroidectomy for papillary thyroid carcinoma between January 2008 and May 2012 were compared to 41 controls who underwent central neck dissection at initial operation.Results
The two groups were well matched for age, sex, and pN stage (P?=?0.296, 0.199, and 1.000, respectively). Three patients had distant metastases at presentation. No significant difference was found concerning mean number of removed nodes (P?=?0.064). No significant difference was found between the reoperative and the control groups concerning transient hypocalcemia (17 vs 19, respectively) (P?=?0.901) and transient recurrent nerve palsy (2 vs 2) (P?=?0.608). Follow-up was completed in 69 out of all the included patients (85.2 %). At a mean follow-up of 33 months, two patients (2.9 %) experienced nodal recurrence.Conclusions
Morbidity of central neck dissection is similar for primary surgery and reoperation. In high-volume centers, reoperative central neck dissection can be safely accomplished when needed, allowing to achieve locoregional control in most of patients. 相似文献73.
74.
75.
Elisabetta Pisu Alessandra Lombardi Daniela De Benedictis Chiarella Bozzo Enrico Chiara Cristiana Baggiore Alberto Bruno Laura Cravero Gianranco Pagano Gianfranco Lenti 《Acta diabetologica》1986,23(3):215-225
Summary Alteration in insulin secretion and reduced peripheral sensitivity to the hormone have been reported in type II diabetes.
In this paper, a comparison is made of basal glucose production (3H-6 glucose), insulin secretion and insulin sensitivityin vivo (hyperglycemic clamp) andin vitro (binding to circulating monocytes) in 24 patients with recently diagnosed type II diabetes, matched for age and fasting glycemia
and divided into non-obese (14 subjects) and moderately obese (10 subjects), and in 9 non-obese controls. The non-obese diabetics
were slightly hyperinsulinemic during fasting (10.8±1.0vs 4.8±0.8 μU/ml in controls, p < 0.0005), with a significant reduction in early and late insulin secretion (14.0±1.5vs 20.8 ± 2.0 μU/ml, p<0.01 and 24.8±3.3vs 34.7±2.14 μU/ml, p<0.025). The insulin sensitivity index MCR/I was significantly reduced (2.30±0.32vs 4.14±0.40, p<0.005). Endogenous glucose production was significantly increased (107±10.2vs 84±3.7 mg/m2 per min, p<0.025) and displayed a positive correlation with fasting glycemia (r=0.51, p<0.05). Insulin binding to monocytes
was significantly lower than in controls (2.36±0.22%vs 4.06±0.32%, p<0.0005). Moderately obese diabetics also were significantly hyperinsulinemic in the fasting state (18.1±2.8
μU/ml, p<0.0005vs controls) but, typically, lacked the early secretory phase (20.6±3.6 μU/mlvs baseline, n.s.). A similar increase of hepatic glucose production (107±11.2 mg/m2 per min, p<0.025vs controls, n.s.vs non-obese diabetics) and decrease of peripheral sensitivity to insulin (MCR/I=1.78±0.31, p<0.0005vs controls, n.s.vs non-obese diabetics) was found in moderately obsese diabetics, as well as a significant reduction of insulin binding to insolated
monocytes (2.62±0.4% p<0.01vs controls, n.s.vs non-obese diabetics). These results confirm that common defects of both non-obese and moderately obese type II diabetics
are: lack of early phase of glucose induced insulin secretion, increase in hepatic glucose production and decrease of peripheral
insulin sensitivity together with reduction of insulin binding to circulating monocytes. The hypothesis of a unique defect
as a cause of hyperglycemia in type II diabetes in early clinical phase is not borne out by the results of this study. Moderate
obesity, even if able to reduce insulin sensitivity, seems to be less important in determining hyperglycemia.
This study was supported by a grant fromConsiglio Nazionale delle Ricerche, P.F. Medicina Preventiva, SP4,Malattie Degenerative, N. 84.02449.56. 相似文献
76.
Pellegrino Musto Lorella Melillo Gina Lombardi Rosella Matera Giuseppedi Giorgio Mario Carotenuto 《British journal of haematology》1991,77(1):50-53
The immunocytochemical detection of multidrug-resistance (MDR) associated P-glycoprotein (P-170) was longitudinally performed on bone marrow smears from 32 responsive patients with acute leukaemia in the different phases of the disease (at diagnosis, in complete remission, at relapse) by means of APAAP technique and monoclonal antibody C219. The whole group of eight patients with presence of P-170 positive cells while in complete remission rapidly relapsed with a high proportion of blasts showing MDR phenotype; they were resistant to further treatments. Twelve out of 24 subjects without cells with MDR phenotype in complete remission remained in this condition, six had a responsive relapse (without significant expression of P-170 in 5/6 patients) and six a resistant relapse. Four patients of this last group significantly expressed P-170. Our data indicate that the detection of scattered P-170 positive cells during complete remission might identify a subset of leukaemic patients with high risk of early and resistant relapse. 相似文献
77.
78.
79.
80.