全文获取类型
收费全文 | 4191篇 |
免费 | 214篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 116篇 |
妇产科学 | 58篇 |
基础医学 | 666篇 |
口腔科学 | 428篇 |
临床医学 | 279篇 |
内科学 | 934篇 |
皮肤病学 | 105篇 |
神经病学 | 356篇 |
特种医学 | 41篇 |
外科学 | 403篇 |
综合类 | 14篇 |
预防医学 | 401篇 |
眼科学 | 56篇 |
药学 | 305篇 |
中国医学 | 22篇 |
肿瘤学 | 197篇 |
出版年
2024年 | 5篇 |
2023年 | 46篇 |
2022年 | 91篇 |
2021年 | 150篇 |
2020年 | 112篇 |
2019年 | 150篇 |
2018年 | 147篇 |
2017年 | 121篇 |
2016年 | 112篇 |
2015年 | 157篇 |
2014年 | 197篇 |
2013年 | 236篇 |
2012年 | 359篇 |
2011年 | 429篇 |
2010年 | 253篇 |
2009年 | 199篇 |
2008年 | 312篇 |
2007年 | 278篇 |
2006年 | 222篇 |
2005年 | 215篇 |
2004年 | 194篇 |
2003年 | 161篇 |
2002年 | 121篇 |
2001年 | 11篇 |
2000年 | 8篇 |
1999年 | 17篇 |
1998年 | 22篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 11篇 |
1994年 | 9篇 |
1993年 | 8篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有4427条查询结果,搜索用时 10 毫秒
81.
82.
Paulo Cesar Koch Nogueira Maria Fernanda Camargo de Carvalho Luciana de Santis Feltran Tulio Konstantyner Ricardo Sesso 《Pediatric nephrology (Berlin, Germany)》2016,31(3):501-507
Background
The aim of this study was to describe the access and factors associated with kidney transplantation for children in different regions of Brazil.Methods
We analyzed a cohort of 1211 children enrolled on the transplant list from January 2011 to December of 2013. We fitted regression models to investigate factors associated with: (a) undergoing kidney transplantation from a deceased donor, and (b) being removed from the waiting list.Results
The incidence of transplantation was uneven across regions, with the lowest rate at 0.4 per million age-related population (pmarp) in the Midwest and the highest incidence rate of 8.3 cases pmarp in the South. Children from the North and the Midwest regions had a 3–4 times lower probability of undergoing a deceased donor transplant (p < 0.05). Apart from the geographic region, age of recipients and GDP influenced the outcome. The likelihood of undergoing transplantation was very low in the youngest children in the North and Midwest. The number of transplant centers was not associated with either outcome.Conclusions
Factors of inequality in transplantation in Brazil are of macroeconomic origin, but there is room to reduce inequalities. Training existing transplant center professionals in the care of children could diminish the discrepancies.83.
Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats 下载免费PDF全文
Gianella A Nobili E Abbate M Zoja C Gelosa P Mussoni L Bellosta S Canavesi M Rottoli D Guerrini U Brioschi M Banfi C Tremoli E Remuzzi G Sironi L 《The American journal of pathology》2007,170(4):1165-1177
Salt-loaded, spontaneously hypertensive stroke-prone rats show progressive increases in blood pressure and proteinuria and accumulate acute-phase proteins in body fluids, modeling events during renal damage. The aim of this study was to assess the pathological events occurring in the kidney of spontaneously hypertensive stroke-prone rats over time and evaluate the effects of statin treatment, which is known to improve renal and cardiovascular outcomes. Kidneys of male spontaneously hypertensive stroke-prone rats euthanized at different stages of proteinuria showed progressive inflammatory cell infiltration, the accumulation of alpha-smooth muscle actin-positive cells, degenerative changes in podocytes, and severe fibrosis. These were accompanied by an imbalance in the plasminogen/plasmin and metalloprotease systems characterized by the increased renal expression of plasminogen activator inhibitor-1, tissue plasminogen activator, and urokinase plasminogen activator; the net result was an increase in plasmin and matrix metalloproteinase (MMP)-2 and a reduction in MMP-9 activity. Chronic treatment with the hydrophilic rosuvastatin had renoprotective effects in terms of morphology and inflammation and prevented the changes in plasmin, MMP-2, and MMP-9 activity. These effects were independent of the changes in blood pressure and plasma lipid levels. Treatment with the lipophilic simvastatin was not renoprotective. These data suggest that rosuvastatin may have potential utility as a therapeutic option in renal diseases that are characterized by inflammation and fibrosis. 相似文献
84.
85.
Marianna Giannini Chiara Primerano Liron Berger Martina Giannaccini Zhigang Wang Elena Landi Alfred Cuschieri Luciana Dente Giovanni Signore Vittoria Raffa 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(8):2656-2665
The 3-D spatial and mechanical features of nano-topography can create alternative environments, which influence cellular response. In this paper, murine fibroblast cells were grown on surfaces characterized by protruding nanotubes. Cells cultured on such nano-structured surface exhibit stronger cellular adhesion compared to control groups, but despite the fact that stronger adhesion is generally believed to promote cell cycle progression, the time cells spend in G1 phase is doubled. This apparent contradiction is solved by confocal microscopy analysis, which shows that the nano-topography inhibits actin stress fiber formation. In turn, this impairs RhoA activation, which is required to suppress the inhibition of cell cycle progression imposed by p21/p27. This finding suggests that the generation of stress fibers, required to impose the homeostatic intracellular tension, rather than cell adhesion/spreading is the limiting factor for cell cycle progression. Indeed, nano-topography could represent a unique tool to inhibit proliferation in adherent well-spread cells. 相似文献
86.
Pereira DI Santurio JM Alves SH Argenta JS Pötter L Spanamberg A Ferreiro L 《The Journal of antimicrobial chemotherapy》2007,60(5):1168-1171
OBJECTIVES: The present study evaluated the susceptibility of 27 clinical isolates of Pythium insidiosum to caspofungin in vitro and correlated the results with the therapeutic response in vivo in rabbits with experimental pythiosis. METHODS: The macrodilution method was performed in accordance with the CLSI document M38-A technique. Three reading criteria for MICs were adopted: MIC0, MIC1 and MIC2 (100%, 90% and 50% growth inhibition, respectively). The minimum fungicidal concentration was also determined. Ten rabbits inoculated with viable P. insidiosum zoospores were divided into two groups: group 1 (control) and group 2 (treated with caspofungin at a dosage of 1 mg/kg/day for 20 consecutive days). RESULTS: Of the isolates 51.8% had an MIC0 of 64 mg/L, 88.8% of isolates had an MIC1 between 8 and 64 mg/L and 62.9% of isolates had a minimum fungicidal concentration of 64 mg/L. In the in vivo assay, growth of subcutaneous lesions reduced during treatment, but rapidly resumed when treatment was stopped. CONCLUSIONS: The results showed that caspofungin has limited fungistatic activity against P. insidiosum. This work is the first study to analyse the susceptibility of this oomycete to inhibitors of beta-glucans of the cellular wall. 相似文献
87.
88.
Sekiguchi RT Paixão CG Saraiva L Romito GA Pannuti CM Lotufo RF 《Journal of clinical periodontology》2007,34(7):545-550
AIM: The aim of this study was to determine the incidence and severity of gingival overgrowth (GO) induced by tacrolimus (Tcr) compared with ciclosporin A (CiA) in the absence of calcium channel blockers (CCB) in renal transplant recipients. METHODS: Forty patients (20 Tcr and 20 CiA) were evaluated before and 30 and 90 days after kidney transplantation. Demographic (age, gender) and periodontal parameters were recorded for all patients. Patients taking CCB at any time during the study were excluded from the investigation. RESULTS: The mean GO score was significantly lower (p=0.014) in the Tcr group (6.4%) compared with the CiA group (17.9%) after 90 days of immunosuppressive therapy. At 90 days post-transplant, clinically significant GO was observed in four patients of the CiA group and in two of the Tcr group. This difference was not statistically significant (0.66). CONCLUSION: No significant difference in the incidence of clinically significant GO was observed between the CiA and Tcr groups up to 90 days of immunosuppressive therapy. 相似文献
89.
Thiago Roberto Lima Romero Raquel Rodrigues Soares Santos Marina Gomes Miranda e Castor Júlia Alvarenga Petrocchi Luciana Souza Guzzo Andre Klein Igor Dimitri Gama Duarte 《Pharmacological reports : PR》2018,70(4):784-788