全文获取类型
收费全文 | 22714篇 |
免费 | 1748篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 195篇 |
儿科学 | 774篇 |
妇产科学 | 621篇 |
基础医学 | 2804篇 |
口腔科学 | 397篇 |
临床医学 | 2764篇 |
内科学 | 4041篇 |
皮肤病学 | 395篇 |
神经病学 | 2094篇 |
特种医学 | 701篇 |
外科学 | 3292篇 |
综合类 | 362篇 |
一般理论 | 38篇 |
预防医学 | 2368篇 |
眼科学 | 546篇 |
药学 | 1598篇 |
3篇 | |
中国医学 | 12篇 |
肿瘤学 | 1490篇 |
出版年
2022年 | 156篇 |
2021年 | 373篇 |
2020年 | 221篇 |
2019年 | 409篇 |
2018年 | 466篇 |
2017年 | 335篇 |
2016年 | 376篇 |
2015年 | 397篇 |
2014年 | 591篇 |
2013年 | 898篇 |
2012年 | 1328篇 |
2011年 | 1443篇 |
2010年 | 750篇 |
2009年 | 679篇 |
2008年 | 1159篇 |
2007年 | 1207篇 |
2006年 | 1205篇 |
2005年 | 1103篇 |
2004年 | 1043篇 |
2003年 | 1024篇 |
2002年 | 903篇 |
2001年 | 511篇 |
2000年 | 542篇 |
1999年 | 461篇 |
1998年 | 250篇 |
1997年 | 173篇 |
1996年 | 186篇 |
1995年 | 182篇 |
1994年 | 142篇 |
1993年 | 161篇 |
1992年 | 420篇 |
1991年 | 367篇 |
1990年 | 379篇 |
1989年 | 349篇 |
1988年 | 359篇 |
1987年 | 326篇 |
1986年 | 307篇 |
1985年 | 333篇 |
1984年 | 260篇 |
1983年 | 219篇 |
1982年 | 149篇 |
1981年 | 126篇 |
1980年 | 121篇 |
1979年 | 237篇 |
1978年 | 172篇 |
1977年 | 124篇 |
1976年 | 116篇 |
1974年 | 119篇 |
1973年 | 128篇 |
1970年 | 116篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
81.
No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs. 总被引:3,自引:0,他引:3 下载免费PDF全文
N W Wood P Holmans D Clayton N Robertson D A Compston 《Journal of neurology, neurosurgery, and psychiatry》1994,57(10):1191-1194
Myelin basic protein was examined as a candidate gene for susceptibility to multiple sclerosis using two adjacent amplification fragment length polymorphisms (AmpFLPs), containing seven and six highly informative alleles respectively. No allelic association was found with multiple sclerosis, comparing 77 cases and 88 controls, and there was no evidence for linkage in 73 affected sibling pairs, using the methods of identity by descent and identity by state. 相似文献
82.
Stacey M Pollock-Barziv Anne I Dipchand Brian W McCrindle Nadya Nalli Lori J West 《The Journal of heart and lung transplantation》2005,24(2):190-194
BACKGROUND: While Tacrolimus (Tac) and Cyclosporine (Cya) immunosuppression are used after cardiac transplantation (tx), few studies have evaluated their use in pediatric patients. METHODS: We randomized 26 heart transplant recipients (pts) in a prospective, open-label trial to Tac (n = 14) or Cya (n = 12) to compare their efficacy and side-effects. Mean age at tx was 4.2 years for Tac and 5.8 years for Cya. Mean follow-up was 26 months (range: 11-39 months) for Tac and 24 months for Cya (range: 33-13 months). RESULTS: Our data suggest that both regimens are efficacious in the pediatric population. Conversion from Cya to Tac was useful for dealing with persistent rejection, although this sample did not suggest lower incidence of acute cellular rejection in the Tac group. CONCLUSIONS: Further studies are required to establish pharmacokinetic parameters to enhance therapeutic monitoring of these patients to minimize side effects and enhance outcomes. 相似文献
83.
Edward D Moloney Jim J Egan Peter Kelly Alfred E Wood Leslie T Cooper 《The Journal of heart and lung transplantation》2005,24(8):1103-1110
Myocarditis is a major cause of end-stage heart failure and is responsible for up to 10% of cases of idiopathic dilated cardiomyopathy (IDC). Worldwide, approximately 45% of all heart transplants are performed for IDC and up to 8% for myocarditis. Early reports suggested that survival after transplantation for myocarditis was poor and patients had an increased risk of rejection. More recently, larger case series suggest that overall survival after transplantation for myocarditis is similar to survival after transplantation for other causes. However, certain disorders, including cardiac sarcoidosis and giant cell myocarditis (GCM), require heightened surveillance for post-transplantation disease recurrence. We present the case of a 42-year-old man with recurrence of GCM 8 years after transplantation and review the literature on the role of cardiac transplantation for patients with myocarditis. 相似文献
84.
Liviu Feller Neil H Wood Johan Lemmer 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(4):455-460
The use of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV) infection has resulted paradoxically in the worsening of clinical symptoms of previously subclinical infections, such as herpes zoster (HZ), herpes simplex, angular cheilitis, warts, tuberculosis, hepatitis B and C, cytomegalovirus retinitis, and others, as a result of substantial reconstitution of the host's immune responses. This phenomenon is referred to as immune reconstitution inflammatory syndrome (IRIS). It may affect up to 32% of HIV-seropositive subjects within a wide range of time after the initiation of HAART, but mainly after 8-12 weeks. Mucocutaneous HZ accounts for 7%-12% of the diseases associated with HIV infection that become worse again when the subject's immunity improves from the administration of HAART. It usually occurs after 4 weeks from the initiation of HAART, and under these circumstances the clinical symptoms and natural course of mucocutaneous HZ are similar to those in HIV-seropositive subjects who do not manifest IRIS. 相似文献
85.
Karen Hunka Oksana Suchowersky Susan Wood Lorelei Derwent Zelma H T Kiss 《The Journal of neuroscience nursing》2005,37(4):204-210
The use of deep brain stimulation (DBS) to treat movement disorders such as Parkinson's disease, essential tremor, and dystonia is increasing. Although some published literature describes the methods for DBS programming, the time and nursing requirements to run a DBS surgical program have not been examined previously. For this study, we prospectively recorded the time required for both assessments and programming of the DBS from the preoperative period to 1 year after surgery in a variety of patients. Results showed that the mean total time spent programming the stimulator and assessing these patients ranged from 18.0-36.2 hours per patient. It took twice as long to program the stimulator in patients with Parkinson's disease as it did in patients with essential tremor or dystonia. When setting up a program for movement disorders surgery, nursing time spent on patient assessment and programming should be considered in the workload. 相似文献
86.
Belinda Garner Andrew M. Chanen Lisa Phillips Dennis Velakoulis Stephen J. Wood Henry J. Jackson Christos Pantelis Patrick D. McGorry 《Psychiatry Research: Neuroimaging》2007,156(3):257-261
This study used magnetic resonance imaging to examine pituitary gland volume (PGV) in teenage patients with a first presentation of borderline personality disorder (BPD). No difference in PGV was observed between healthy controls (n = 20) and the total BPD cohort (n = 20). However, within the BPD cohort, those exposed to childhood trauma (n = 9) tended to have smaller pituitaries (− 18%) than those with no history of childhood trauma (n = 10). These preliminary findings suggest that exposure to childhood trauma, rather than BPD, per se, might be associated with reduced PGV, possibly reflecting hypothalamic–pituitary–adrenal axis dysfunction. 相似文献
87.
88.
T S Rao J A Cler R P Compton M R Emmett S Mick E T Sun S Iyengar P L Wood 《Neuropharmacology》1990,29(3):305-309
Following intravenous administration, 1-aminocyclobutane-1-carboxylate (ACBC, 100 mg/kg), a N-methyl-D-aspartate (NMDA)-associated glycine receptor antagonist, was eliminated with a T1/2 of 5 min in mouse brain and 4 min in rat cerebrospinal fluid (CSF). 1-Aminocyclopropane-1-carboxylate (ACC), a NMDA-associated glycine receptor agonist, was found to have a T1/2 of less than 5 min in mouse brain. ACC and ACBC did not alter basal cerebellar cGMP. Glycine and D-serine increased cGMP, and 1-hydroxy-3-aminopyrrolidone-2 (HA-966), a glycine antagonist, reversed the D-serine-induced increases in cGMP. In contrast, ACBC did not reverse the D-serine-induced increases in cGMP. These data suggest that despite their brain bioavailability and marked potency at the glycine receptor in vitro, ACC and ACBC are rapidly inactivated and thus have limited in vivo utility. 相似文献
89.
90.
Hepatic failure associated with imipramine therapy 总被引:1,自引:0,他引:1
Imipramine, a widely used antidepressant, has rarely been associated with hepatic abnormalities. In the majority of reported cases, hepatic effects have been transient and readily reversible on discontinuation of the drug. We cared for an 11-year-old boy with hepatic failure and massive cell necrosis which followed treatment with imipramine for enuresis. This therapy led to fulminant hepatic failure and subsequent liver transplantation. 相似文献