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121.
Mario Sanna Yogesh Jain Giuseppe De Donato Lorenzo RohitLauda Abdelkader Taibah 《Otology & neurotology》2004,25(5):797-804
OBJECTIVE: The objective of this study was to review the outcome of surgical management in patients of jugular paragangliomas. STUDY DESIGN: We conducted a retrospective case review. SETTING: Tertiary care otology and skull base center. MATERIALS AND METHODS: Fifty-five patients with the diagnosis of a jugular paraganglioma (Fisch Class C and D Glomus Jugulare) were managed over a period of 15 years. All patients with adequate follow up and complete records (53 cases) were reviewed with emphasis on the results of surgical management and the factors influencing them. INTERVENTION: All 53 patients were managed with a view to surgically extirpate the tumor. The primary approach was the infratemporal fossa approach-Type A used in the majority of the patients. In eight cases, the procedure was staged owing to the presence of large intracranial extension. Three patients required additional procedures to ameliorate the after-effects of lower cranial nerve resection. RESULTS: Gross total tumor removal was achieved in 49 patients. There were five cases of recurrence. Coupled with the residual tumors in five patients, the surgical control achieved was 83%. There was no perioperative mortality. There were two cases of postoperative cerebrospinal fluid leak, both of which required surgical exploration and closure. The facial nerve was resected in seven patients. The overall preservation rate of clinically uninvolved lower cranial nerves was 75%. CONCLUSIONS: The low level of complications along with a high surgical control achieved makes surgery the primary mode of treatment in the vast majority of these tumors, regardless of the size and location. 相似文献
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Justo Lorenzo Bermejo Kari Hemminki 《Cancer epidemiology, biomarkers & prevention》2005,14(7):1738-1740
BACKGROUND: Tobacco smoking is the principal cause of lung cancer. The risk of lung cancer in the offspring of lung cancer patients is about twice higher than the risk in the general population. The present study investigated the contribution of shared smoking habits to the familial clustering of lung cancer. METHODS: We estimated the relative risk of lung cancer attributable to smoking according to the extent to which smokers transmit their smoking habits to the offspring (heritability of smoking), the prevalence of smoking in the general population, and the risk of lung cancer for smokers compared with nonsmokers. FINDINGS: The relative risk of lung cancer for the offspring of lung cancer patients attributable to smoking was 1.19 when published data on smoking practice were modeled (i.e., assuming that the heritability of smoking was 0.5, the smoking prevalence 40%, and the odds ratio of lung cancer for smokers versus nonsmokers was 20). INTERPRETATION: Most familial cases of lung cancer cannot be attributed to shared smoking habits. The example of smoking can be used for other familial cancers, for which no strong environmental risk factors are usually known, to infer the primary role for heritable genes. 相似文献
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Early and late implant failure of submerged versus non‐submerged implant healing: A systematic review,meta‐analysis and trial sequential analysis
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Pasquale Capaccio Nicola Luca Paolo Enrico Sigismund Lorenzo Pignataro 《European archives of oto-rhino-laryngology》2012,269(5):1551-1554
Aplasia of the major salivary glands is a rare condition due to an alteration in the development of the ectodermal tissue
of the oral cavity often related to other craniofacial abnormalities or alteration of structures deriving from the first or
second archial branch, in particular the lacrimal glands; it can be total or partial and determine clinical states ranging
from an asymptomatic condition to a severe xerostomia. The accessory parotid tissue is similar to normal parotid tissue, completely
independent from the main gland and susceptible to the same pathological disorders. We describe a very unusual case of an
inflammatory disorder of accessory parotid tissue in a 44-year-old male patient with concomitant, and previously unknown,
aplasia of the main ipsilateral parotid gland. We also discuss the role of imaging and conservative therapeutic modalities
such as botulinum toxin therapy and, in the future, minimally invasive endoscopic-assisted resection in the management of
such salivary disorder. 相似文献