全文获取类型
收费全文 | 1615篇 |
免费 | 119篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 34篇 |
妇产科学 | 38篇 |
基础医学 | 269篇 |
口腔科学 | 87篇 |
临床医学 | 141篇 |
内科学 | 386篇 |
皮肤病学 | 45篇 |
神经病学 | 178篇 |
特种医学 | 51篇 |
外科学 | 118篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 107篇 |
眼科学 | 51篇 |
药学 | 112篇 |
中国医学 | 4篇 |
肿瘤学 | 119篇 |
出版年
2023年 | 13篇 |
2022年 | 28篇 |
2021年 | 66篇 |
2020年 | 38篇 |
2019年 | 56篇 |
2018年 | 61篇 |
2017年 | 64篇 |
2016年 | 56篇 |
2015年 | 64篇 |
2014年 | 89篇 |
2013年 | 95篇 |
2012年 | 142篇 |
2011年 | 159篇 |
2010年 | 80篇 |
2009年 | 61篇 |
2008年 | 85篇 |
2007年 | 89篇 |
2006年 | 91篇 |
2005年 | 105篇 |
2004年 | 68篇 |
2003年 | 64篇 |
2002年 | 46篇 |
2001年 | 15篇 |
2000年 | 11篇 |
1999年 | 2篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 3篇 |
1993年 | 6篇 |
1992年 | 8篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1981年 | 6篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1969年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有1748条查询结果,搜索用时 31 毫秒
41.
Lars Donath Lukas Zahner Ralf Roth Livia Fricker Mareike Cordes Henner Hanssen Arno Schmidt-Trucksäss Oliver Faude 《European journal of applied physiology》2013,113(3):661-669
Impaired balance and gait performance increase fall-risk in seniors. Acute effects of different exercise bouts on gait and balance were not yet addressed. Therefore, 19 healthy seniors (10 women, 9 men, age: 64.6 ± 3.2 years) were examined on 3 days. After exhaustive treadmill testing, participants randomly completed a 2-km treadmill walking test (76 ± 8 % VO2max) and a resting control condition. Standing balance performance (SBALP) was assessed by single limb-eyes opened (SLEO) and double limb-eyes closed (DLEC) stance. Gait parameters were collected at comfortable walking velocity. A condition × time interaction of center of pressure path length (COPpath) was observed for both balance tasks (p < 0.001). Small (Cohen’s d = 0.42, p = 0.05) and large (d = 1.04, p < 0.001) COPpath increases were found after 2-km and maximal exercise during DLEC. Regarding SLEO, slightly increased COPpath occurred after 2-km walking (d = 0.29, p = 0.65) and large increases after exhaustive exercise (d = 1.24, p < 0.001). No significant differences were found for gait parameters. Alterations of SBALP after exhaustive exercise might lead to higher fall-risk in seniors. Balance changes upon 2-km testing might be of minor relevance. Gait is not affected during single task walking at given velocities. 相似文献
42.
43.
Trasca Livia Sanchis Laura Regueiro Ander Freixa Xavier Vinereanu Dragos Sitges Marta 《The international journal of cardiovascular imaging》2021,37(5):1577-1585
The International Journal of Cardiovascular Imaging - The aim of our study was to assess the anatomical changes of the mitral valve apparatus after percutaneous repair with the MitraClip®... 相似文献
44.
45.
Muhammad Ahsan Javed Georg Beyer Nha Le Alessio Vinci Helen Wong Daniel Palmer Robert D. Morgan Angela Lamarca Richard A. Hubner Juan W. Valle Salma Alam Sumsur Chowdhury Yuk Ting Ma Livia Archibugi Gabriele Capurso Patrick Maisonneuve Albrecht Neesse Malin Sund Sebastian Krug 《Pancreatology》2019,19(1):97-104
Background
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. Gemcitabine is the standard chemotherapy for patients with metastatic pancreatic adenocarcinoma (MPA). Randomized clinical trials evaluating intensified chemotherapies including FOLFIRINOX and nab-paclitaxel plus gemcitabine (NAB+GEM) have shown improvement in survival. Here, we have evaluated the efficacy of intensified chemotherapy versus gemcitabine monotherapy in real-life settings across Europe.Methods
A retrospective multi-center study including 1056 MPA patients, between 2012 and 2015, from nine centers in UK, Germany, Italy, Hungary and the Swedish registry was performed. Follow-up was at least 12 months. Cox proportional Harzards regression was used for uni- and multivariable evaluation of prognostic factors.Results
Of 1056 MPA patients, 1030 (98.7%) were assessable for survival analysis. Gemcitabine monotherapy was the most commonly used regimen (41.3%), compared to FOLFIRINOX (n = 204, 19.3%), NAB+GEM (n = 81, 7.7%) and other gemcitabine- or 5-FU-based regimens (n = 335, 31.7%). The median overall survival (OS) was: FOLFIRINOX 9.9 months (95%CI 8.4–12.6), NAB+GEM 7.9 months (95%CI 6.2–10.0), other combinations 8.5 months (95%CI 7.7–9.3) and gemcitabine monotherapy 4.9 months (95%CI 4.4–5.6). Compared to gemcitabine monotherapy, any combination of chemotherapeutics improved the survival with no significant difference between the intensified regimens. Multivariable analysis showed an association between treatment center, male gender, inoperability at diagnosis and performance status (ECOG 1–3) with poor prognosis.Conclusion
Gemcitabine monotherapy was predominantly used in 2012–2015. Intensified chemotherapy improved OS in comparison to gemcitabine monotherapy. In real-life settings, the OS rates of different treatment approaches are lower than shown in randomized phase III trials. 相似文献46.
Milena Dropa Barbara Ghiglione Maria Helena Matté Livia Carminato Balsalobre Nilton Lincopan Glavur Rogério Matté Gabriel Gutkind Pablo Power 《Antimicrobial agents and chemotherapy》2015,59(3):1815-1817
CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime. 相似文献
47.
Sophie?L.?WoolstonEmail author Shireesha?Dhanireddy Jeanne?Marrazzo 《Current infectious disease reports》2016,18(11):36
While ocular syphilis is not a new phenomenon, recent increased rates of new diagnoses, especially in human immunodeficiency virus (HIV)-infected persons and men who have sex with men, have sparked a new interest in an old disease. This article will review the clinical presentation, diagnosis, and treatment of ocular syphilis, and provide guidance on management. 相似文献
48.
49.
Iole Vozza Francesca Fusco Denise Corridore Livia Ottolenghi 《Medicina oral, patología oral y cirugía bucal》2015,20(4):e413-e418
Background
The aim of the study was to focus the awareness of complications of oral piercing among a group of adolescents and young Italian adults with intraoral piercings.Material and Methods
A total of 225 teenagers were asked to complete a questionnaire on the awareness of complications of oral piercing. An additional questionnaire was administered in case of oral piercing worn, based on site piercing, knowledge about piercer license, oral and systemic risks due to oral piercing, disinfection and sterilization of the material pierced, information by the piercer about piercing hygiene maintenance and post-piercing dentist check-up. After questionnaire all partecipants received a brochure with some information about risks and maintenance mode of piercing.Results
Data revealed that more than 50% of teens surveyed was found to wear a piercing. Only 25.3% was aware of the risk of HCV cross-infection and only 17.3% reported of knowledge about risk of endocarditis. Only 17% checked the piercer license and only 18% sterilization and disinfection of the materials used. 53.7% did not received explanations about the risks associated with piercing. With regard to the maintenance mode of the piercing, it has been suggested to brush the piercing bar in 17% of cases. The post piercing specialist visits have been suggested only in 7% of cases.Conclusions
The general lack of awareness of complications and maintenance mode related to oral piercing needs to be addressed by some education programs performed at school and by dentists. Key words: Oral piercing, oral health, oral complications. 相似文献50.
“CHARGE‐like presentation,craniosynostosis and mild Mowat–Wilson Syndrome diagnosed by recognition of the distinctive facial gestalt in a cohort of 28 new cases” American Journal of Medical Genetics Part A. 164:2557‐2566, 2014
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tara L. Wenger Margaret Harr Stefania Ricciardi Elizabeth Bhoj Avni Santani Margaret P. Adam Sarah S. Barnett Rebecca Ganetzky Donna M. McDonald‐McGinn Domenica Battaglia Stefania Bigoni Angelo Selicorni Giovanni Sorge Matteo Della Monica Francesca Mari Elena Andreucci Silvia Romano Guido Cocchi Salvatore Savasta Baris Malbora Giuseppe Marangi Livia Garavelli Marcella Zollino Elaine H. Zackai 《American journal of medical genetics. Part A》2015,167(7):1682-1683