全文获取类型
收费全文 | 266935篇 |
免费 | 24962篇 |
国内免费 | 18487篇 |
专业分类
耳鼻咽喉 | 2295篇 |
儿科学 | 2777篇 |
妇产科学 | 3301篇 |
基础医学 | 30367篇 |
口腔科学 | 4987篇 |
临床医学 | 36347篇 |
内科学 | 37898篇 |
皮肤病学 | 2852篇 |
神经病学 | 14027篇 |
特种医学 | 10551篇 |
外国民族医学 | 149篇 |
外科学 | 27655篇 |
综合类 | 46485篇 |
现状与发展 | 67篇 |
一般理论 | 27篇 |
预防医学 | 17393篇 |
眼科学 | 7505篇 |
药学 | 27693篇 |
244篇 | |
中国医学 | 15729篇 |
肿瘤学 | 22035篇 |
出版年
2024年 | 876篇 |
2023年 | 4104篇 |
2022年 | 10532篇 |
2021年 | 13463篇 |
2020年 | 10312篇 |
2019年 | 8659篇 |
2018年 | 9325篇 |
2017年 | 8439篇 |
2016年 | 7763篇 |
2015年 | 12292篇 |
2014年 | 15251篇 |
2013年 | 13721篇 |
2012年 | 20312篇 |
2011年 | 22586篇 |
2010年 | 14401篇 |
2009年 | 11644篇 |
2008年 | 14619篇 |
2007年 | 14287篇 |
2006年 | 14341篇 |
2005年 | 13888篇 |
2004年 | 8808篇 |
2003年 | 8074篇 |
2002年 | 6682篇 |
2001年 | 5762篇 |
2000年 | 6037篇 |
1999年 | 6172篇 |
1998年 | 3799篇 |
1997年 | 3756篇 |
1996年 | 2980篇 |
1995年 | 2743篇 |
1994年 | 2284篇 |
1993年 | 1445篇 |
1992年 | 1949篇 |
1991年 | 1645篇 |
1990年 | 1324篇 |
1989年 | 1121篇 |
1988年 | 1039篇 |
1987年 | 908篇 |
1986年 | 745篇 |
1985年 | 529篇 |
1984年 | 342篇 |
1983年 | 244篇 |
1982年 | 151篇 |
1981年 | 147篇 |
1980年 | 113篇 |
1979年 | 145篇 |
1977年 | 54篇 |
1975年 | 57篇 |
1974年 | 57篇 |
1973年 | 50篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
Keyang Qian Hanqing Qian Juan Cai Wuheng Yue Xiaoxiao Yu Baorui Liu 《Pathology, research and practice》2019,215(4):755-760
Gastric cancer, one of the most common disease, has become a major public health problem worldwide. Cisplatin (DDP) has been a widely used drug for the treatment of cancer, also usually applied in gastric cancer in clinic. However, the side effects including toxicity and drug-resistance restricted the usage of DDP in clinic, so we prepared a DDP-complexed hydrogel (DDP-Gel) and investigated its efficacy in gastric cancer. For in vivo studies, MKN45-Luc cells were injected into BLAB/C node mice subcutaneously to establish gastric cancer with orthotopically grown tumors. Mice bearing tumors were treated with normal saline, DDP and DDP-Gel. Body weight and survival condition were observed and recorded. The treatment efficacy in vivo was detected by luciferase imaging and histological evaluation was performed by H&E staining of different organs. Additionally, normal ICR mice were treated with different doses of DDP/DDP-Gel to calculate their LD50 in vivo. The results showed that DDP-Gel prolonged survival time and ameliorated body weight changes of mice bearing tumors. DDP-Gel exhibited higher efficacy to inhibit tumor growth and metastasis, compared to DDP. Besides, LD50 of DDP-Gel was 166.0?mg/kg, 13.2 folds higher than DDP. As a conclusion, DDP-Gel showed a more effective and safer function than DDP in gastric cancer, which indicating that DDP-Gel might be a novel strategy for gastric cancer therapy. 相似文献
52.
53.
以专培学员为主导的CBL教学对心血管专培学员自身综合能力提升的影响 《医学教育管理》2021,7(5):550
心血管专科医师规范化培训目标要求高于住院医师培训,完成心血管专培的医生应能在医疗、教学、科研能力上明显提高,达到心血管专科主治医师水平。如何提高心血管专培学员教学能力是专培中的难点。将专培学员随机分为两组,分别采用案例教学法(case-based learning, CBL)和传统教学法进行带教,课程结束后通过测验和调查问卷两种方式对教学效果进行考察。旨在探讨由心血管专培学员主导CBL教学法在实施过程中是否对其自身综合能力有所提升。结果显示,CBL教学法组学生临床理论及病例分析考试分数均高于对照组;心血管专培学员通过主导CBL教学,在教学能力、组织能力和学科协调均有提升;相较传统教学法,CBL教学法的教学效果更佳,有利于心血管专培学员自身综合能力提升。 相似文献
54.
55.
Joseph Wheatley Zhengyang Liu Joel Loth Mark P. Plummer Jahan C. Penny-Dimri Reny Segal Julian Smith Luke A. Perry 《Acta anaesthesiologica Scandinavica》2023,67(2):131-141
Background
Patients undergoing cardiac surgery are at significant risk of developing postoperative acute kidney injury (AKI). Neutrophil–lymphocyte ratio (NLR) is a widely available inflammatory biomarker which may be of prognostic value in this setting.Methods
We conducted a systematic review and meta-analysis of studies reporting associations between perioperative NLR with postoperative AKI. We searched Medline, Embase and the Cochrane Library, without language restriction, from inception to May 2022 for relevant studies. We meta-analysed the reported odds ratios (ORs) with 95% confidence intervals (CIs) for both elevated preoperative and postoperative NLR with risk of postoperative AKI and need for renal replacement therapy (RRT). We conducted a meta-regression to explore inter-study statistical heterogeneity.Results
Twelve studies involving 10,724 participants undergoing cardiac surgery were included, with eight studies being deemed at high risk of bias using PROBAST modelling. We found statistically significant associations between elevated preoperative NLR and postoperative AKI (OR 1.45, 95% CI 1.18–1.77), as well as postoperative need for RRT (OR 2.37, 95% CI 1.50–3.72). Postoperative NLR measurements were not of prognostic significance.Conclusions
Elevated preoperative NLR is a reliable inflammatory biomarker for predicting AKI following cardiac surgery. 相似文献56.
Yuan Peng Yuman Li Haiyan Cao Liu Hong Yu Wang Mingxing Xie 《Journal of ultrasound in medicine》2019,38(2):539-544
A pulmonary artery (PA) sling is a very rare congenital cardiovascular anomaly, and only a few studies have reported PA slings in fetuses. The relationship of the PA, aorta, ductus arteriosus, and trachea can be evaluated in the 3‐vessel and 3‐vessel and trachea views during fetal echocardiography. A PA sling can be detected by abnormal positioning of the left PA in relation to the trachea when sweeping from the 3‐vessel view cranially to the 3‐vessel and trachea view. Here we report 3 cases of fetal PA slings and their follow‐ups. Two cases were confirmed by postnatal echocardiography, and the other case was confirmed by a cardiovascular cast after pregnancy termination. We emphasize that the 3‐vessel and 3‐vessel and trachea views are of crucial importance in the prenatal diagnosis of a PA sling. 相似文献
57.
Liu Shu-Juan Liu Zhen-Zhen Wang Ze-Ying Li Yuan-Yuan Jia Cun-Xian 《Zeitschrift fur Gesundheitswissenschaften》2022,30(2):513-521
Journal of Public Health - Sleep-disordered breathing (SDB) is common among adolescents and is associated with short- and long-term consequences. Data on the prevalence and epidemiologic... 相似文献
58.
59.
60.
Yuanqing Yao Jun Qian Shunkang Rong Yuwen Huang Bo Xiong Gang Yang Dengqing Zhang Shimin Deng Jie Tan Que Zhu Changming Deng Dichuan Liu Haitao Ran Zhigang Wang Jing Huang 《Ultrasound in medicine & biology》2019,45(2):490-499
Stellate ganglion (SG) modification has been investigated for arrhythmia treatment. In this study, transesophageal SG imaging and intervention were explored using a homemade 30F integrated focused ultrasonic catheter in healthy mongrel canines in vivo. Anatomic details of SGs were ultrasonically imaged and evaluated. SG had a heterogeneous echoic structure and characteristic profiles sketched by hyper-echoic outlines in an ultrasonogram. Left SGs in the experimental group were successfully ablated through the esophagus under ultrasonic guidance provided by the catheter itself. Two weeks after the ablation, the QT and QTc of the experimental group decreased compared with those of the sham group and at baseline (both p values < 0.001). Histologic examination revealed that left SGs were destroyed. No major complications were observed. This approach may be further explored as a method for ganglia remodeling evaluation and as a strategy of ganglia modification for arrhythmia and for other diseases. 相似文献