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Robert J. Harris Susan Y. Bookheimer Timothy F. Cloughesy Hyun J. Kim Whitney B. Pope Albert Lai Phioanh L. Nghiemphu Linda M. Liau Benjamin M. Ellingson 《Journal of neuro-oncology》2014,116(2):373-379
The purpose of the current study was to explore whether brain tumors disrupt the integrity of the default mode network (DMN), a well-characterized resting-state fMRI network. We evaluated whether tumor grade, volume, post-surgical/clinical status, or location decreased the functional connectivity within the DMN in patients with gliomas. Task-based fMRI data was obtained from 68 diffuse glioma patients and 12 healthy volunteers. Pseudo-resting state fMRI data was calculated from task-based fMRI data using standard techniques. Data was preprocessed and DMN integrity was compared across WHO grade, tumor volume surgical status (new vs. recurrent tumors), age, and KPS using univariate and multivariate linear models. WHO grade was the most significant predictor of DMN integrity (P = 0.004), whereas T2 hyperintense lesion volume was not a predictor (P = 0.154). DMN integrity was lower in high-grade (WHO III–IV) compared with low-grade (WHO II) patients (P = 0.020). Tumors in the left parietal lobe showed a more impaired DMN compared with tumors in the frontal lobe, while tumors within and outside the network nodes did not differ significantly. Results suggest higher tumor grade along with prior surgery and/or treatment cause the largest reduction in DMN functional connectivity in patients with primary gliomas, and that tumor location has an impact on connectivity. 相似文献
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A. Rosich-Medina S.S. Liau A. Jah E. Huguet T.C. See N. Jamieson R. Praseedom 《International journal of surgery case reports》2010,1(3):33-36
Percutaneous transhepatic biliary drainage (PTBD) is commonly used in the management of cholangiocarcioma. Major and minor complications of PTBD such as cholangitis, haemorrhage and catheter dislocation are well documented. A lesser reported complication are cutaneous metastases following PTBD for cholangiocarcinoma.We report a case of a 79 year old man who presented with right upper quadrant pain, jaundice and weight loss, with dilated intra-hepatic bile ducts on imaging. The cytology results from a sample taken during endoscopic retrograde cholangiopancreatography were highly suspicious of cholangiocarcioma. A PTBD was subsequently performed and bilateral metal biliary stents were placed without external drainage. Five months after the PTBD he was found to have a hard nodule under the PTBD puncture site. The nodule was excised and the histology confirmed a cholangiocarcinoma metastasis.A review of the literature identified twelve cases of cutaneous metastases from cholangiocarcinoma, following PTBD. In addition, tumour seeding along the catheter tract following PTBD, with metastatic deposits on the abdominal wall, peritoneoum, chest wall, pleural space, and liver parenchyma have also been reported.Health care professionals should be aware of this rare complication and offer appropriate management options to patients. 相似文献
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Ann. Hum. Genet . (1999), 63 , 473–482
Correction
The authors wish to add the following correction to this paper:
The genomic organization of the human organic cation transporter (hOCT1/SLC22A1) has recently been described by us to consist of 7 exons [Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1( hOCT1 / SLC22A1 ); Ann. Hum. Genet . 63 : 473–482]. A reexamination revealed 11 exons instead of 7. The mistake occurred through cDNA contamination. The corrected gene structure of the hOCT1 gene is available at EMBL under the following accession numbers:
AJ243995 (Exon 1), AJ243996 (Exon 2), AJ276051 (Exon 3), AJ276052 (Exon 4), AJ276053 (Exon 5 and 6), AJ245460 (Exon 7), AJ243998 (Exon 8), AJ243999 (Exon 9 and 10) and AJ244000 (Exon 11). 相似文献
Correction
The authors wish to add the following correction to this paper:
The genomic organization of the human organic cation transporter (hOCT1/SLC22A1) has recently been described by us to consist of 7 exons [Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1( hOCT1 / SLC22A1 ); Ann. Hum. Genet . 63 : 473–482]. A reexamination revealed 11 exons instead of 7. The mistake occurred through cDNA contamination. The corrected gene structure of the hOCT1 gene is available at EMBL under the following accession numbers:
AJ243995 (Exon 1), AJ243996 (Exon 2), AJ276051 (Exon 3), AJ276052 (Exon 4), AJ276053 (Exon 5 and 6), AJ245460 (Exon 7), AJ243998 (Exon 8), AJ243999 (Exon 9 and 10) and AJ244000 (Exon 11). 相似文献
77.
Volumetric rendering techniques: applications for three-dimensional imaging of the hip 总被引:1,自引:0,他引:1
Fishman EK; Drebin B; Magid D; Scott WW Jr; Ney DR; Brooker AF Jr; Riley LH Jr; St. Ville JA; Zerhouni EA; Siegelman SS 《Radiology》1987,163(3):737-738
Volumetric rendering is a new approach to three-dimensional (3D) imaging that overcomes many of the drawbacks of currently available surface-rendering systems. Its application on the Pixar Imaging System in two cases of acetabular fracture was assessed to illustrate the features of the technique. The fast-computing architecture and large memory of this system allow rapid generation of a series of high-quality 3D images in each plane of rotation (x or spinal axis, z or somersaulting axis) that can be viewed as independent static images or as an animated real-time video loop. Editing to remove the normal contralateral hemipelvis enhances appreciation of acetabular abnormalities. Every pixel of computed tomographic data is preserved, allowing representation of both soft tissue and bone as translucent overlap. The presentation of data also allows detection of subtle abnormalities and features and minimizes the artifact generation common in surface-rendered images. 相似文献
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79.
Immunosuppressive acidic protein (IAP) was first found in the ascitic fluids of cancer patients. Its biochemical properties are significantly different from those of acidic protein in the serum of normal persons. Previous studies have indicated that the serum IAP concentration increases in most cancer patients and decreases to a normal level as such patients are cured. Therefore, it has been suggested as a useful marker for follow-up in operated cancer patients. In this study, analyses and comparisons of serum IAP concentrations have been made among 53 normal persons in Blackfoot disease endemic areas, 25 patients with diabetes, cataracts, hypertension and cardiovascular disease in Blackfoot disease endemic areas, 50 breast cancer patients, 13 colorectal cancer patients, and 18 Blackfoot disease patients. Serum IAP concentrations were found as follows: 454 +/- 138 micrograms/ml for normal subjects and 499 +/- 132 micrograms/ml for disease patients in Blackfoot disease endemic areas; 520 +/- 149 micrograms/ml for breast cancer patients; 864 +/- 341 micrograms/ml for colorectal cancer patients and 950 +/- 368 micrograms/ml for Blackfoot disease patients. Serum IAP concentrations were much higher in Blackfoot disease patients, than in normal persons in Blackfoot disease endemic areas (p less than 0.001), and as high as in colorectal cancer patients. In Blackfoot disease patients, the mean serum IAP concentration of 6 patients coming from the Blackfoot disease endemic areas was as high as 1,238 +/- 404 micrograms/ml, showing a positive rate of 100% to IAP (i.e. IAP concentration exceeds 500 micrograms/ml). We conclude that serum IAP assay of Blackfoot disease patients may be useful for prognosis and therapeutic monitoring. 相似文献
80.
Evaluation of monoclonal antifibrin antibodies by their binding to human blood clots 总被引:2,自引:0,他引:2
The primary goal of this study was to develop a method for evaluating fibrin-specific antibodies as thrombus detecting agents. The apparatus and assay conditions were chosen by testing antibody 64C5, which binds to the amino terminus of the fibrin beta chain, for its ability to bind to human blood clots. Using 125I-labeled antibody 64C5, the effects of antibody concentration, clot shape, clot mass, temperature, and flow rate were tested. Increased antibody binding was observed when antibody concentration, clot mass and temperature were increased. Under one set of conditions, six 125I-labeled monoclonal antifibrin antibodies (four specific for the beta chain, two specific for the alpha chain) were tested for their binding to retracted clots of human blood. Two radioiodinated antidigoxin antibodies were used as a control. Beta chain-specific antibody 59D8, which provided the highest level of binding to clot, bound 14-fold better than the control antidigoxin antibody. Neither alpha chain-specific antibody bound to clotted blood. To examine the in vivo relevance of the in vitro binding to clots, the uptake of antibody 64C5 was assessed for its binding to human fibrin clotted within the jugular vein of a rabbit. The correlation coefficient between in vitro and in vivo uptake as a function of clot weight was calculated to be 0.91. Thus, in vitro binding of monoclonal antifibrin antibodies to human blood clots was judged to be a realistic method for the comparison and selection of an ideal antifibrin antibody for detailed in vivo testing. 相似文献