中西药联合胆肾推经仪治疗肝内胆管结石38例临床观察

目的 观察胆维他、25％硫酸镁、中药消炎利胆Ⅰ号联合胆肾推经仪治疗肝内胆管结石的临床疗效。方法 38例肝内胆管结石患者口服消炎利胆Ⅰ号溶石化石，胆维他利胆消炎保肝，25％硫酸镁解痉止痛扩张肝胆管。配合胆肾推经平板式电极刺激和手柄式电极推按，确定排石体位、结石部位，调节仪器频率和强度，疗程为10天和30天。结果 治疗后，经B超、胆囊造影、CT检查对比，排石总有效率91．61％。其中排净27例（占71．05％），显效8例（占20．56％），无效3例（占7．9％），与治疗前相比，差异有显著性（P〈0．1〉。结论 中西药联合胆肾推经仪治疗肝内胆管结石可明显提高排石率，改善胆道炎症，消除黄疸，是一种安全有效，经济方便的治疗方法。     

与长寿有关的特殊脂蛋白表型和基因型

背景：长寿个体年龄相关疾病的发病率较低且发病时凤明显后延，其家族成员可能遗传有某些调节衰老过程或疾病敏感性的因子。     

肌蒂移植术治疗陈旧性脊髓损伤(附56例报告)

作者采用肌蒂移植术治疗胸腰段陈旧性脊髓损伤56例.脊髓功能恢复率提高至Franke 1个等级以上者占76.8%(43/56).本文讨论了肌蒂移植术对陈旧性脊髓损伤的适应证.安徽省宿州市骨伤科医院淮北煤矿基建局医院     

正常人眼筛板的结缔组织纤维结构

采用组化特染，透射电镜和图象分析仪观察了３５只正常人眼筛板结缔组织的纤维成分和结构形态，根据生物力学原理分析了筛束的力学性质和筛板的结构特征，探讨了筛板的损害形式和在眼压与视神经损害间的中介作用及其影响因素。结果显示，筛束含有细胞间质所有三种纤维，具有弹性、塑性和刚性三重复合性质，筛板纵向椭圆、筛束行径和密度象限性差异及筛板厚度个体性差异等与筛板抗损害性能有关。眼压对筛板作用有两种途径，筛板损害是     

影响煤工尘肺病人减寿的因素分析

目的：探讨影响煤工尘肺患者减寿的因素，为进一步开展煤工尘肺的三级预防提供依据。方法：用非条件logistic回归分析对可能影响尘肺病人减寿的一些因素进行多因素逐步回归分析。结果：疗养和及时离尘是保护因子，有利于尘肺病人健康；吸烟、工种、初诊期别、Ⅰ期晋Ⅱ期的年限、合并肺结核是危险因子。结论：今后对尘肺病人三级预防的重点是防制肺结核和及时脱离粉尘接触。     

精神心理、社会环境因素与妊高征关系的研究进展

随着生物医学模式向生物—心理—社会医学模式的转变 ,心理社会因素与妊高征的关系愈来愈受到医学界的普遍关注和重视。该文对精神心理因素、社会环境因素与妊高征发生、发展的关系及其原因作一综述。     

Practical usage concentrations of monensin have non-specific actions other than as a sodium ionophore in rat parotid acinar cells.

Monensin is used as a sodium ionophore to examine the effect of Na+ on cellular function in a variety of cell types. In the present study, we investigated the effects of different concentrations of monensin on the signal transduction system in exocrine parotid acinar cells. Monensin increased cytosolic free Na+ concentration, measured by the Na+ indicator sodium-binding benzofuran isophthalate in a concentration-dependent manner (0.01 to 100 microM). Likewise, monensin concentration-dependently increased amylase release and intracellular Ca2+ concentration in the presence and the absence of extracellular Ca2+. Low concentrations (0.01 to 1 microM) of monensin did not release Ca2+ from non-mitochondrial intracellular pools in permeabilized cells with saponin but high concentrations (10 and 100 microM) of monensin which are of practical usage did. Monensin itself did not change the cyclic AMP accumulation, whereas high concentrations (10 and 100 microM) but not low concentrations (0.01 to 1 microM) of monensin inhibited cyclic AMP accumulation elevated by isoproterenol in the presence and absence of extracellular Na+. These results indicate that high concentrations of monensin, which are practically used, have nonspecific actions in rat parotid acinar cells, and lower concentrations of monensin are recommended for use as a sodium ionophore.     

Basic fibroblast growth factor in human prostate cancer cells.

To increase our understanding of the potential role of basic fibroblast growth factor (bFGF) in malignant progression of prostate cancer, we determined the production of bFGF, the expression of FGF receptor (flg), and the response to exogenous bFGF in LNCaP, DU 145, and PC 3 cells. We observed that these three prostate cancer cell lines, which differed in their dependence on androgens for growth in vitro and in their in vivo behavior in nude mice, could be distinguished as follows: (a) androgen-sensitive LNCaP cells, which do not metastasize in nude mice, did not produce measurable amounts of bFGF, expressed small but measurable amounts of FGF receptor mRNA, and did respond to exogeneous bFGF; (b) androgen-insensitive, moderately metastatic DU 145 cells did produce measurable amounts of biologically active bFGF, expressed large amounts of FGF receptor mRNA, and responded to exogeneous bFGF and the heparin-binding fractions from DU 145 cell extracts; (c) androgen-insensitive and highly metastatic PC3 cells also produced measurable amounts of bFGF but did not demonstrate a growth response to either the heparin-binding fractions from PC3 cell extracts or exogenous bFGF, even though large amounts of FGF receptor mRNA were expressed in PC 3 cells. These results suggest the possibility that differences in production of, and response to, bFGF may be associated with different biological behavior.     

同型半胱氨酸对大鼠血管平滑肌细胞胶原蛋白合成及其mRNA表达的影响

目的 :观察同型半胱氨酸 ( Hcy)对血管平滑肌细胞 ( VSMCs)胶原合成的影响 ,并探讨其作用机制。方法 :本实验采用体外培养的大鼠 VSMCs,加入不同浓度的 Hcy,通过 3 H-脯氨酸掺入、α1[ ]型胶原测定观察 Hcy对 VSMCs胶原合成的影响 ,并通过半定量 RT- PCR检测其对 α1[ ]型胶原 m RNA表达的影响。结果 :Hcy促进 VSMCs的胶原合成及 α1[ ]型胶原 m RNA表达 ,并呈剂量依赖效应。结论 :Hcy促进 VSMCs的胶原合成 ,可能是通过促进 α1[ ]型胶原 m RNA表达实现的。提示 Hcy促进胶原合成可能是动脉粥样硬化的发病机制之一     

Mathematical modelling in risk/exposure assessment of tobacco related lung cancer

The existence of a dose-related increase of lung cancer riskin cigarette smokers has been indisputably established. Thisfinding, however, is not confirmed at low doses (< 5 cigarettes/day),there still being a lack of epidemiological data. The use ofmathematical models of carcinogenesis to extrapolate from higherdoses allows estimation of the risk for very light smokers.The present study has been designed to compare a set of mathematicalmodels, i.e. one-hit, two-stage, multi-stage, logit, probit,and Weibull, in extrapolating relative risks at low doses fromthe data of nine large cohort studies on cigarette smokers reportedin the IARC Scientific Monograph on tobacco smoking. All modelsevaluated, apart from the one-hit, achieved a good fit, withthe proportion of explained variance ranging between 61% and67%. The relative risk estimates for passive smokers from themost updated epidemiological studies were taken into accountto evaluate, on the basis of these models, the correspondingexposure in terms of ‘cigarette equivalent’ smoked.These values ranged from 0.21 to 0.43 cigarettes/day for thetwo-stage and multistage model, while probit, logit and Weibullmodels, yielded estimates one or even two orders of magnitudelower. The authors emphasize the substantial agreement betweenthe estimates of ‘cigarette equivalent9 based on the applicationof two-stage and multi-stage models to the epidemiological evidenceon the effect of passive smoking and to the data based on thecomparison of tobacco metabolites in active and passive smokers.