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971.
Health service funding mechanisms are pivotal in the pursuit of health system objectives, as they provide strong financial
incentives for actors in the system to achieve policy goals. Underpinning funding mechanisms is a set of key economic principles,
or objectives, that should guide their design and use: efficiency, equity, and accountability. The Australian health system
has historically performed relatively poorly in relation to these objectives, with evidence of inefficiencies, inequities,
and poor accountability in many areas of health services. The primary cause of these shortcomings may lie in the complex set
of funding and delivery arrangements at the State and Federal levels of government. Potentially significant improvements in
the performance of the health system would be available from the integration of the funding and delivery of services within
a single tier of government, coupled with the development of a national weighted capitation approach to funding. To develop
a national capitation funding model a number of unique factors require consideration, including the current fragmentation
of services, the role of the private sector, the needs of indigenous populations, and the effects of rurality. The data available
to develop a capitation model is of a level of detail and quality not readily found elsewhere. If policy statements promoting
efficiency, accountability, and particularly equity are to be actively pursued, a national capitation model based on robust
methods should become a cornerstone of Australian health system reform.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
972.
Burkhard Moellenbeck Frank Horst Georg Gosheger Christoph Theil Leonie Seeber Tobias Kalisch 《The Journal of arthroplasty》2021,36(3):885-891
BackgroundSpouses are the primary caregivers of patients living with osteoarthritis (OA). Little is known about how the quality of life (QoL) of OA patients’ partners change after total joint replacement surgery (TJR).MethodsPreoperative health status and 12-month postoperative outcomes were evaluated and compared in 24 couples using the Short-Form 36 (SF-36), knee or hip specific Osteoarthritis Outcome Score (OOS) and accelerometry for the assessment of habitual physical activity (PA) and sedentary behavior (SB). Correlations between the changes in the patients’ OOS subscales scores, habitual activity, and their partners’ SF-36 scores were calculated.ResultsFollowing TJR the patients’ OOS subscale scores showed positive changes (P < .001). The SF-36 physical component summary (PCS) score improved (P < .001), while the mental component summary (MCS) score as well as PA and SB remained unchanged (P ≥ .093). Their partners’ PCS, MCS, and SB did not change (P ≥ .286), whereas the PA even decreased (P = .027). Correlation analyses showed positive results for the changes in the patients’ OOS subscale pain and the changes in their partners’ MCS (r = 0.355, P = .048) as well as the changes in the patients’ OOS subscale activities of daily living and the changes in the PCS of their partners (r = 0.406, P = .027). In contrast to the results described above, changes in the patients’ PA were negatively correlated with changes in their partners’ PCS (r = ?0.389, P = .033).ConclusionTJR has a positive influence on QoL but not the habitual activity of OA patients. Their partners, on the other hand, show no changes in QoL and even a slight decrease in habitual activity. 相似文献
973.
Helen L. Barrett Marloes Dekker Nitert Michael DEmden Barbara Lingwood Susan de Jersey H. David McIntyre Leonie K. Callaway 《Nutrients》2021,13(4)
Background: Maternal triglycerides are increasingly recognised as important predictors of infant growth and fat mass. The variability of triglyceride patterns during the day and their relationship to dietary intake in women in late pregnancy have not been explored. This prospective cohort study aimed to examine the utility of monitoring capillary triglycerides in women in late pregnancy. Methods: Twenty-nine women (22 with gestational diabetes (GDM) and 7 without) measured capillary glucose and triglycerides using standard meters at home for four days. On two of those days, they consumed one of two standard isocaloric breakfast meals: a high-fat/low-carbohydrate meal (66% fat) or low fat/high carbohydrate meal (10% fat). Following the standard meals, glucose and triglyceride levels were monitored. Results: Median capillary triglycerides were highly variable between women but did not differ between GDM and normoglycaemic women. There was variability in capillary triglycerides over four days of home monitoring and a difference in incremental area under the curve for capillary triglycerides and glucose between the two standard meals. The high-fat standard meal lowered the incremental area under the curve for capillary glucose (p < 0.0001). Fasting (rho 0.66, p = 0.0002) and postpradial capillary triglycerides measured at home correlated with venous triglyceride levels. Conclusions: The lack of differences in response to dietary fat intake and the correlation between capillary and venous triglycerides suggest that monitoring of capillary triglycerides before and after meals in pregnancy is unlikely to be useful in the routine clinical practice management of women with gestational diabetes mellitus. 相似文献
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976.
In Vitro Cellular Adaptations of Indicators of Longevity in Response to Treatment with Serum Collected from Humans on Calorie Restricted Diets
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Joanne S. Allard Leonie K. Heilbronn Carolina Smith Nicole D. Hunt Donald K. Ingram Eric Ravussin Pennington CALERIE Team Rafael de Cabo 《PLoS Clinical Trials》2008,3(9)
Calorie restriction (CR) produces several health benefits and increases lifespan in many species. Studies suggest that alternate-day fasting (ADF) and exercise can also provide these benefits. Whether CR results in lifespan extension in humans is not known and a direct investigation is not feasible. However, phenotypes observed in CR animals when compared to ad libitum fed (AL) animals, including increased stress resistance and changes in protein expression, can be simulated in cells cultured with media supplemented with blood serum from CR and AL animals. Two pilot studies were undertaken to examine the effects of ADF and CR on indicators of health and longevity in humans. In this study, we used sera collected from those studies to culture human hepatoma cells and assessed the effects on growth, stress resistance and gene expression. Cells cultured in serum collected at the end of the dieting period were compared to cells cultured in serum collected at baseline (before the dieting period). Cells cultured in serum from ADF participants, showed a 20% increase in Sirt1 protein which correlated with reduced triglyceride levels. ADF serum also induced a 9% decrease in proliferation and a 25% increase in heat resistance. Cells cultured in serum from CR participants induced an increase in Sirt1 protein levels by 17% and a 30% increase in PGC-1α mRNA levels. This first in vitro study utilizing human serum to examine effects on markers of health and longevity in cultured cells resulted in increased stress resistance and an up-regulation of genes proposed to be indicators of increased longevity. The use of this in vitro technique may be helpful for predicting the potential of CR, ADF and other dietary manipulations to affect markers of longevity in humans. 相似文献
977.
Haider Jan Boriana Guimicheva Srirupa Gosh Rosol Hamid Leonie Penna Ippokratis Sarris 《International journal of gynaecology and obstetrics》2014
Objective
To evaluate whether eponymous maneuvers and mnemonics taught for the management of shoulder dystocia, vaginal breech delivery, and uterine inversion were remembered and understood in practice.Methods
A questionnaire was distributed to obstetricians and midwives collecting information about the HELPERR and PALE SISTER mnemonics. Three extended matching questions evaluated participants’ knowledge of the correct maneuvers, with their matching eponyms, used in the management of shoulder dystocia, vaginal breech delivery, and uterine inversion.Results
Of the 112 participants, 90% were familiar with the HELPERR mnemonic, with 79% using it in their practice. Of those who used it, only 32% could correctly decipher it (P = 0.032). PALE SISTER was mostly unfamiliar. The percentages of correct maneuvers used for managing shoulder dystocia, breech delivery, and uterine inversion were 84.6%, 58.3%, and 28.6%, respectively. However, the eponyms were correctly matched to their maneuvers in only 33.3%, 14.3%, and 0% of cases, respectively (P < 0.01).Conclusion
The meanings of the mnemonics for obstetric emergencies were frequently recalled incorrectly. This, together with the poor correlation between knowledge of maneuvers and their eponyms, limits their usefulness and indicates that teaching should focus on learning without relying on mnemonics and eponyms. 相似文献978.
Higher body mass index is associated with reduced posterior default mode connectivity in older adults
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Frauke Beyer Sharzhad Kharabian Masouleh Julia M. Huntenburg Leonie Lampe Tobias Luck Steffi G Riedel‐Heller Markus Loeffler Matthias L. Schroeter Michael Stumvoll Arno Villringer A. Veronica Witte 《Human brain mapping》2017,38(7):3502-3515
Obesity is a complex neurobehavioral disorder that has been linked to changes in brain structure and function. However, the impact of obesity on functional connectivity and cognition in aging humans is largely unknown. Therefore, the association of body mass index (BMI), resting‐state network connectivity, and cognitive performance in 712 healthy, well‐characterized older adults of the Leipzig Research Center for Civilization Diseases (LIFE) cohort (60–80 years old, mean BMI 27.6 kg/m2 ± 4.2 SD, main sample: n = 521, replication sample: n = 191) was determined. Statistical analyses included a multivariate model selection approach followed by univariate analyses to adjust for possible confounders. Results showed that a higher BMI was significantly associated with lower default mode functional connectivity in the posterior cingulate cortex and precuneus. The effect remained stable after controlling for age, sex, head motion, registration quality, cardiovascular, and genetic factors as well as in replication analyses. Lower functional connectivity in BMI‐associated areas correlated with worse executive function. In addition, higher BMI correlated with stronger head motion. Using 3T neuroimaging in a large cohort of healthy older adults, independent negative associations of obesity and functional connectivity in the posterior default mode network were observed. In addition, a subtle link between lower resting‐state connectivity in BMI‐associated regions and cognitive function was found. The findings might indicate that obesity is associated with patterns of decreased default mode connectivity similar to those seen in populations at risk for Alzheimer's disease. Hum Brain Mapp 38:3502–3515, 2017. © 2017 Wiley Periodicals, Inc. 相似文献
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980.
Federica De Majo Leonie Martens Jana-Charlotte Hegenbarth Frank Rühle Magda R. Hamczyk Rosa M. Nevado Vicente Andrs Erika Hilbold Christian Br Thomas Thum Martine de Boer Dirk J. Duncker Blanche Schroen Anne-Sophie Armand Monika Stoll Leon J. De Windt 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(36)