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971.
972.
973.
Lena Borell Eric Asaba Lena Rosenberg Marie-Louise Schult Elisabeth Townsend 《Scandinavian journal of occupational therapy》2013,20(2):76-85
The aim of this paper is to advance our understanding of participation and its relation to occupation, by analysing the daily occupational experiences of six men and women living with chronic pain. Open-ended interviews are used in conjunction with a constant comparative method of analysis. The findings are thematically presented as: “taking initiative and making choices”, doing something physical”, “doing something social”, and “doing something for others”. Furthermore, a short vignette is presented in which the authors attempt to juxtapose theoretical constructs with individual experiences in order to illustrate another level of contextual richness of the data. Methodological implications are discussed in relation to the findings, analytic presentation, and previous research. 相似文献
974.
Åsa Larsson Lena Haglund Jan-Erik Hagberg 《Scandinavian journal of occupational therapy》2013,20(2):99-109
The purpose of this article is to explore how a group of elderly people, living and managing on their own, describe and experience their everyday doings. Interviews and observations were conducted with 18 community-living people aged 85 and above. The experiences of ‘Doing everyday life’ are described in five overarching themes: ‘Experiencing being old’, ‘Doings in everyday life’, ‘Patterns of the day’, ‘Altered doings’, and ‘The importance of time’. What is done during an ordinary day does not differ much from earlier in life, but how the doings are performed has changed. Being occupied and staying healthy and sound in mind was stressed as important in old age and even if reduced energy and functional constraints limited the doings, a strong volition to manage independently was expressed. The participants perceived society as regarding the elderly as useless and worthless. Knowledge emanating from the very old themselves is vital to diversify the image of elderly people and to offer interventions and support adapted to their needs and desires. 相似文献
975.
Peggy M. L. H. Vencken MD Mieke Kriege PhD Maartje Hooning PhD Marian B. Menke‐Pluymers MD PhD Bernadette A. M. Heemskerk‐Gerritsen MSc Lena C. van Doorn MD PhD Margriet M. Collée MD PhD Agnes Jager MD PhD Cees van Montfort PhD Curt W. Burger MD PhD Caroline Seynaeve MD PhD 《Cancer》2013,119(5):955-962
BACKGROUND:
The objective of this study was to assess the incidence of primary breast cancer (PBC) and contralateral breast cancer (CBC) in patients who had BRCA1/BRCA2‐associated epithelial ovarian cancer (OC).METHODS:
From the database of the Rotterdam Family Cancer Clinic, patients who had BRCA‐associated OC without a history of unilateral breast cancer (BC) (at risk of PBC; n = 79) or with a history of unilateral BC (at risk of CBC; n = 37) were selected. The control groups consisted of unaffected BRCA mutation carriers (n = 351) or mutation carriers who had a previous unilateral BC (n = 294), respectively. The risks of PBC and CBC were calculated using the Kaplan‐Meier survival method with death considered as a competing risk event.RESULTS:
Women with BRCA‐associated OC had lower 2‐year, 5‐year, and 10‐year risks of PBC (3%, 6%, and 11%, respectively) compared with unaffected mutation carriers (6%, 16%, and 28%, respectively; P = .03), although they had a considerably higher mortality rate at similar time points (13%, 33%, and 61%, respectively, vs 1%, 2%, and 2%, respectively; P < .001). In BRCA mutation carriers with a previous unilateral BC, the 2‐year, 5‐year, and 10‐year risks of CBC were nonsignificantly lower in patients with OC than in those without OC (0%, 7%, and 7%, respectively, vs 6%, 16%, and 34%, respectively; P = .06), whereas the mortality rate was higher in patients with OC (19%, 34%, and 55%, respectively, vs 4%, 11%, and 21%, respectively; P < .001).CONCLUSIONS:
Patients with BRCA‐associated OC had a lower risk of developing a subsequent PBC or CBC than mutation carriers without OC, whereas the risk of dying from OC was greater than the risk of developing BC. These data may facilitate more tailored counseling for this patient subgroup, although confirmative studies are warranted. Cancer 2013. © 2012 American Cancer Society. 相似文献976.
Anna Ansell Lena K. Thunell Stina Garvin Karin Roberg 《International journal of cancer. Journal international du cancer》2013,133(8):1994-2003
Head and neck squamous cell carcinoma (HNSCC) is a malignancy that is associated with severe mortality despite advances in therapy. Today's standard treatment most commonly includes radiotherapy, often combined with chemotherapy or surgery. There are so far no established biomarkers to predict response to radiation, and thus the aim of this study was to investigate a series of markers that could potentially identify HNSCC patients who would benefit from radiotherapy. The selected markers, both proteins (epidermal growth factor receptor, survivin and p53), and single nucleotide polymorphisms (SNPs) in the genes of XRCC3, XRCC1, XPC, XPD, MDM2, p53 and FGFR4 were correlated to the response to radiotherapy and overall survival. Investigations were performed on pretreatment tumor biopsies from patients classified as responders or nonresponders to radiotherapy. Protein expression was examined using immunohistochemistry and the genotyping of specific SNPs was analyzed using PCR‐RFLP or pyrosequencing. We found that survivin expression was significantly stronger in the responder group (p = 0.003) and that patients with a strong survivin expression had a significantly better overall survival (p < 0.001). Moreover, downregulation of survivin by siRNA in two HNSCC cell lines significantly decreased their sensitivity to radiation. Among the SNPs analyzed, patients with the XPD Lys751Gln SNP had a significantly shorter overall survival (p = 0.048), and patients with the FGFR4 Gly388Arg SNP had a significantly longer overall survival (p = 0.010). In conclusion, our results suggest that survivin plays an important role in the response to radiotherapy and may be a useful marker for predicting radiotherapy response in patients with HNSCC. 相似文献
977.
Tatjana Schwarz Pinkus Tober-Lau David Hillus Elisa T. Helbig Lena J. Lippert Charlotte Thibeault Willi Koch Irmgard Landgraf Janine Michel Leon Bergfeld Daniela Niemeyer Barbara Mühlemann Claudia Conrad Chantip Dang-Heine Stefanie Kasper Friederike Münn Kai Kappert Andreas Nitsche Rudolf Tauber Sein Schmidt Piotr Kopankiewicz Harald Bias Joachim Seybold Christof von Kalle Terry C. Jones Norbert Suttorp Christian Drosten Leif Erik Sander Victor M. Corman Florian Kurth 《Emerging infectious diseases》2021,27(8):2174
We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary. 相似文献
978.
979.
Stefan Eser Nina Reiff Marlena Messer Barbara Seidler Kathleen Gottschalk Melanie Dobler Maren Hieber Andreas Arbeiter Sabine Klein Bo Kong Christoph W. Michalski Anna Melissa Schlitter Irene Esposito Alexander J. Kind Lena Rad Angelika E. Schnieke Manuela Baccarini Dario R. Alessi Dieter Saur 《Cancer cell》2013,23(3):406-420
980.
Chandra Prakash Prasad Shivendra Kumar Chaurasiya Lena Axelsson Tommy Andersson 《Molecular oncology》2013,7(5):870-883
An important role for WNT-5A is implicated in a variety of tumors, including breast carcinoma. We previously showed that WNT-5A signaling inhibits migration and metastasis of breast cancer cells, and that patients with primary breast cancer in which WNT-5A was expressed have a better prognosis. Despite the fact that RhoGTPase Cdc42 is commonly associated with increased cell migration, we here show that recombinant WNT-5A activates the Cdc42 in breast cancer cells (lines MDA-MB468 and MDA-MB231) in a time-dependent manner. Activation of Cdc42 was also observed in MDA-MB468 cells that were stably transfected with a WNT-5A plasmid (MDA-MB468-5A). In all situations, increased Cdc42 activity was accompanied by decreased migration and invasion of the breast cancer cells. To explore these findings further we also investigated the effect of WNT-5A signaling on ERK1/2 activity. Apart from an initial Ca2+-dependent rWNT-5A-induced activation of ERK1/2, Cdc42 activity was inversely correlated with ERK1/2 activity in both rWNT-5A-stimulated parental MDA-MB468 and MDA-MB468-5A cells. We also demonstrated increased ERK1/2 activity in MDA-MB468-5A cells following siRNA knockdown of Cdc42. Consistent with these results, breast cancer cells transfected with constitutively active Cdc42 exhibited reduced ERK1/2 activity, migration and invasion, whereas cells transfected with dominant negative Cdc42 had increased ERK1/2 activity in response to rWNT-5A. To gain information on how ERK1/2 can mediate its effect on breast cancer cell migration and invasion, we next investigated and demonstrated that WNT-5A signaling and constitutively active Cdc42 both decreased matrix metalloproteinase 9 (MMP9) activity. These data indicate an essential role of Cdc42 and ERK1/2 signaling and MMP9 activity in WNT-5A-impaired breast cancer cells. 相似文献