全文获取类型
收费全文 | 5115篇 |
免费 | 378篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 92篇 |
儿科学 | 194篇 |
妇产科学 | 143篇 |
基础医学 | 684篇 |
口腔科学 | 118篇 |
临床医学 | 660篇 |
内科学 | 907篇 |
皮肤病学 | 128篇 |
神经病学 | 630篇 |
特种医学 | 129篇 |
外科学 | 535篇 |
综合类 | 42篇 |
一般理论 | 2篇 |
预防医学 | 467篇 |
眼科学 | 37篇 |
药学 | 323篇 |
中国医学 | 8篇 |
肿瘤学 | 420篇 |
出版年
2024年 | 7篇 |
2023年 | 81篇 |
2022年 | 123篇 |
2021年 | 157篇 |
2020年 | 128篇 |
2019年 | 167篇 |
2018年 | 184篇 |
2017年 | 158篇 |
2016年 | 179篇 |
2015年 | 186篇 |
2014年 | 211篇 |
2013年 | 305篇 |
2012年 | 395篇 |
2011年 | 394篇 |
2010年 | 192篇 |
2009年 | 193篇 |
2008年 | 337篇 |
2007年 | 308篇 |
2006年 | 258篇 |
2005年 | 257篇 |
2004年 | 238篇 |
2003年 | 213篇 |
2002年 | 203篇 |
2001年 | 41篇 |
2000年 | 29篇 |
1999年 | 46篇 |
1998年 | 48篇 |
1997年 | 40篇 |
1996年 | 19篇 |
1995年 | 22篇 |
1994年 | 33篇 |
1993年 | 22篇 |
1992年 | 19篇 |
1991年 | 25篇 |
1990年 | 27篇 |
1989年 | 18篇 |
1988年 | 21篇 |
1987年 | 14篇 |
1986年 | 21篇 |
1985年 | 12篇 |
1984年 | 24篇 |
1983年 | 13篇 |
1982年 | 21篇 |
1981年 | 13篇 |
1980年 | 17篇 |
1979年 | 11篇 |
1978年 | 14篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1973年 | 10篇 |
排序方式: 共有5519条查询结果,搜索用时 15 毫秒
51.
52.
Nicole-Ann Lim Ooiean Teng Chester Yan Hao Ng Lena X. Y. Bao Paul Anantharajah Tambyah Amy M. L. Quek Raymond C. S. Seet 《Annals of medicine》2022,54(1):1488
BackgroundAccumulating data suggest antiviral effects of povidone-iodine against the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. This narrative review aims to examine the antiviral mechanisms of povidone-iodine, efficacy of povidone-iodine against the SARS-CoV-2 virus, and safety of povidone-iodine to human epithelial cells and thyroid function.MethodsWe searched the electronic databases PubMed, Embase, Cochrane Library, ClinicalTrials.gov and World Health Organization’s International Clinical Trials Registry Platform for articles containing the keywords “povidone-iodine”, “SARS-CoV-2” and “COVID-19” from database inception till 3 June 2021.ResultsDespite in vitro data supporting the anti-SARS-CoV-2 effects of povidone-iodine, findings from clinical studies revealed differences in treatment response depending on study settings (healthy vs. hospitalized individuals), treatment target (nasal vs. oral vs. pharynx), method of administration (oral rinse vs. gargle vs. throat spray) and choice of samples used to measure study endpoints (nasopharyngeal vs. saliva). One large-scale clinical trial demonstrated reduction in the incidence of SARS-CoV-2 infection among participants who administered povidone-iodine 3 times daily during an active outbreak. Povidone-iodine is also used to disinfect the oro-pharyngeal space prior to dental or otolaryngology procedures. Although existing data suggest minimal impact of povidone-iodine on thyroid function, high-quality safety data are presently lacking.ConclusionsPovidone-iodine application to the oropharyngeal space could complement existing non-pharmacological interventions to reduce SARS-CoV-2 infection especially in high exposure settings.
Key messages
- Accumulating data suggest antiviral effects of povidone-iodine against the SARS-CoV-2 virus.
- Findings from clinical studies reveal differences in treatment response depending on study settings, treatment target, method of administration and choice of samples used to measure study endpoints. One large-scale clinical trial observed reduction in the incidence of SARS-CoV-2 infection among participants who administered povidone-iodine 3 times daily during an active outbreak.
- Povidone-iodine application to the oropharyngeal space could complement existing non-pharmacological interventions to reduce SARS-CoV-2 infection especially in high exposure settings.
53.
54.
K E Pershall C F Koopmann S W Coulthard 《International journal of pediatric otorhinolaryngology》1986,11(2):199-203
Sialadenitis in children has been discussed. A literature review highlighting salient points in sialadenitis is presented. Classification of sialadenitis is discussed using the categories of several authors. An unusual case involving acute suppurative parotitis in a child is presented. The development of contralateral disease while treatment was in progress was unusual. In this case, association with mumps parotitis was strongly suspected despite previous immunization. Progression of disease with abscess formation is also unusual. Mumps virus parotitis has been rarely reported in association with acute suppurative parotitis. Immunization affords protection, but a definite failure rate exists. Based upon histologic examination, mumps parotitis would seem to be a predisposing factor for bacterial infection. 相似文献
55.
Timmermans A van Doorn LC Opmeer BC Kroeks MV Duk MJ Bouwmeester AM Kruitwagen RF Dijkhuizen FP Mol BW;Dutch Study in Postmenopausal Bleeding 《Obstetrics and gynecology》2008,111(1):137-143
OBJECTIVE: To estimate the incidence of recurrent postmenopausal bleeding among women who were diagnosed with an endometrial thickness greater than 4 mm. METHODS: We designed a prospective cohort study and included consecutive women not using hormone replacement therapy, presenting with a first episode of postmenopausal bleeding. We evaluated patients who had an endometrial thickness greater than 4 mm at transvaginal ultrasonography and benign endometrial sampling; presence of carcinoma was ruled out by office endometrial sampling, hysteroscopy, and/or dilation and curettage. Time until recurrent bleeding was measured, and diagnosis at recurrent bleeding was recorded. RESULTS: Among 318 patients who had an endometrial thickness greater than 4 mm, 222 patients had benign histology results and were available for follow-up. During follow-up, 47 (21%, 95% confidence interval 16-27%) patients had recurrent bleeding, with a median time to recurrent bleeding of 49 weeks (interquartile range 18 to 86 weeks). There was no difference with respect to recurrence rate between patients with polyp removal, patients with a normal hysteroscopy, and patients with office endometrial sampling alone at the initial workup. Two patients were diagnosed with atypical endometrial hyperplasia upon recurrent bleeding. CONCLUSION: The recurrence rate of postmenopausal bleeding in women with endometrial thickness greater than 4 mm is 20%. This recurrence rate is not related to incorporation of hysteroscopy or polyp removal at the initial workup. LEVEL OF EVIDENCE: II. 相似文献
56.
57.
58.
59.
The plasma protein pattern of patients with uncomplicated essential hypertension showed only slight variations from the normal while that of patients with severely malignant hypertension showed marked shifts. The fibrinogen and β-globulins were usually elevated beyond the normal range and the albumin decreased. In less severely malignant hypertension, the changes were less marked. In dogs with experimental renal hypertension, the γ-globulin level was greatly elevated, and in one animal exhibiting the malignant syndrome β-globulin and fibrinogen were also increased. Elevation of β-globulin seems in some manner associated with the occurrence of severe vascular disease. 相似文献
60.
Raul Zamora-Ros Valerie Cayssials Mazda Jenab Joseph A. Rothwell Veronika Fedirko Krasimira Aleksandrova Anne Tjønneland Cecilie Kyrø Kim Overvad Marie-Christine Boutron-Ruault Franck Carbonnel Yahya Mahamat-Saleh Rudolf Kaaks Tilman Kühn Heiner Boeing Antonia Trichopoulou Elissavet Valanou Effie Vasilopoulou Giovanna Masala Valeria Pala Salvatore Panico Rosario Tumino Fulvio Ricceri Elisabete Weiderpass Torkjel M. Sandanger Cristina Lasheras Antonio Agudo Maria-Jose Sánchez Pilar Amiano Carmen Navarro Eva Ardanaz Emily Sonestedt Bodil Ohlsson Lena Maria Nilsson Martin Rutegård Bas Bueno-de-Mesquita Kay-Thee Khaw Nicholas J. Wareham Kathryn Bradbury Heinz Freisling Isabelle Romieu Amanda J. Cross Paolo Vineis Augustin Scalbert 《European journal of epidemiology》2018,33(11):1063-1075
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2?=?1.06, 95% CI 0.99–1.14) or in men (HRlog2?=?0.97, 95% CI 0.90–1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2?=?0.91, 95% CI 0.85–0.97) and positively associated with rectal cancer in women (HRlog2?=?1.10, 95% CI 1.02–1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women. 相似文献