Glial decline and loss of homeostatic support rather than inflammation defines cognitive aging

The preservation of cognitive longevity and arresting the pandemic of senile dementia engulfing the modern world is arguably the major challenge faced by biomedical research in the 21st century.Age is the leading risk factor for neurodegenerative diseases and vascular dementia,and yet there is a clear distinction between physiological and pathological brain aging.     

Comparative effects of amlodipine (stamlo) and enalapril (enam) on arterial pressure, painless myocardial ischemia and diastolic function of left ventricle in patients with arterial hypertension

43 patients with mild and moderate arterial hypertension received monotherapy with either stamlo (Dr. Reddy's laboratories, India) in a daily dose 9.5 +/- 0.5 mg (n = 33), or enam (n = 26) in a daily dose 28 +/- 1.5 mg, or stamlo treatment was followed in 10 days by enam (n = 16). Before and after the treatment 24-h monitoring was made of arterial pressure, left ventricular diastolic function and silent myocardial ischemia. Adequate lowering of arterial pressure was observed in 90 and 77% of patients after stamlo and enam treatment, respectively. Stamlo showed more potent antiischemic action and had a positive effect on left ventricular filling.     

Effect of methyluracil on the sensitivity of animals to cardiac glycosides and on the coronary blood flow]

Tests conducted with rabbits, cats and mice showed methyluracil to lower the sensitivity to strophanthin in rabbits with myocardial infarction and in intact mice and its intravenous introduction reducing the toxicity of Adonis L. in cats. Oral administration of methyluracil for one week did not prevent in critical tests a strophanthin-induced arrhythmia in intact rabbits and in those with myocardial infarction. Intravenous administration of methyluracil caused an increase of the coronary circulation rate.