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排序方式: 共有3096条查询结果,搜索用时 15 毫秒
991.
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Larry J. Siever Thomas R. Insel Dennis L. Murphy Marian S. Kafka C.Raymond Lake 《Psychiatry research》1983,9(1):37-44
Platelet α2-adrenergic receptor number and physiologic responsiveness, as well as plasma norepinephrine (NE), were evaluated in psychiatric patients with major depressive disorder before and during chronic clorgyline treatment. The α2-adrenergic receptor number was determined by measuring the binding of tritiated dihydroergocriptine (3H-DHE) to platelet membranes. Physiologic responsiveness was determined by measuring the response of cyclic adenosine 3'-5' monophosphate (cAMP) to prostaglandin E1 (PGE1), and the inhibition of the PGE1-stimulated cAMP response by NE in intact platelets. No significant differences from pretreatment values were observed in platelet α2-adrenergic binding or responsiveness during clorgyline treatment. Baseline platelet cAMP production and plasma NE levels were significantly decreased after chronic clorgyline treatment. Previous studies on animals and humans have suggested that brain α2-adrenergic receptor responsiveness decreases during chronic clorgyline treatment. The present findings therefore suggest that such changes may represent adaptations induced by long-term clorgyline administration which may differ between the brain and the platelet, thus illustrating potential limitations of the study of platelet α2-adrenergic receptors as a model for central α2-adrenergic receptor adaptation. 相似文献
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A 60-year-old patient with cyclic hemoptysis for 30 years was found to have bronchiectasis that was not present when hemoptysis began. Thoracic endometriosis and its possible relationship to bronchiectasis are discussed. 相似文献
996.
C E de la Vega S Slater M G Ziegler C R Lake D L Murphy 《Clinical pharmacology and therapeutics》1977,21(2):216-221
Plasma norepinephrine levels were reduced to 30% of placebo levels during the administration of fenfluramine, 120 mg/day, for 10 or more days. There was also a significant reduction in plasma dopamine beta-hydroxylase activity during fenfluramine treatment, suggesting that chronic administration may induce antiadrenergic effects which may be useful in the treatment of disorders affected by circulating catecholamines. 相似文献
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Computed tomography of the breast. A preliminary report 总被引:2,自引:0,他引:2
Chang CH; Sibala JL; Gallagher JH; Riley RC; Templeton AW; Beasley PV; Porte RA 《Radiology》1977,124(3):827
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