全文获取类型
收费全文 | 11394篇 |
免费 | 700篇 |
国内免费 | 172篇 |
专业分类
耳鼻咽喉 | 198篇 |
儿科学 | 74篇 |
妇产科学 | 135篇 |
基础医学 | 2088篇 |
口腔科学 | 327篇 |
临床医学 | 970篇 |
内科学 | 1860篇 |
皮肤病学 | 455篇 |
神经病学 | 1044篇 |
特种医学 | 642篇 |
外科学 | 1566篇 |
综合类 | 41篇 |
一般理论 | 2篇 |
预防医学 | 464篇 |
眼科学 | 279篇 |
药学 | 1254篇 |
中国医学 | 151篇 |
肿瘤学 | 716篇 |
出版年
2024年 | 7篇 |
2023年 | 77篇 |
2022年 | 292篇 |
2021年 | 475篇 |
2020年 | 200篇 |
2019年 | 304篇 |
2018年 | 358篇 |
2017年 | 276篇 |
2016年 | 389篇 |
2015年 | 504篇 |
2014年 | 650篇 |
2013年 | 729篇 |
2012年 | 1044篇 |
2011年 | 978篇 |
2010年 | 622篇 |
2009年 | 528篇 |
2008年 | 741篇 |
2007年 | 755篇 |
2006年 | 643篇 |
2005年 | 559篇 |
2004年 | 447篇 |
2003年 | 384篇 |
2002年 | 316篇 |
2001年 | 223篇 |
2000年 | 194篇 |
1999年 | 129篇 |
1998年 | 68篇 |
1997年 | 46篇 |
1996年 | 32篇 |
1995年 | 29篇 |
1994年 | 21篇 |
1993年 | 19篇 |
1992年 | 34篇 |
1991年 | 33篇 |
1990年 | 31篇 |
1989年 | 23篇 |
1988年 | 16篇 |
1987年 | 17篇 |
1986年 | 8篇 |
1985年 | 9篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1969年 | 2篇 |
1968年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Oh Kee Kwon Kyu-Chang Wang Chong Jai Kim In-One Kim Je G. Chi Byung-Kyu Cho 《Child's nervous system》1996,12(10):633-636
Primary spinal cord primitive neuroectodermal tumor (PNET) is a rare entity. In all, 13 cases have been reported in the literature, including 3 with intracranial seeding. A 3-month-old girl with involvement of the spinal cord below the mid-thoracic level is described. The brain MRI revealed findings indicative of seeding along the intracranial subarachnoid space. Biopsy, duraplasty and removal of laminotomy flap were done. In spite of a good response to the first cycle of postoperative 8-drugs-in-a-day chemotherapy, further treatment was refused. She died 21 days after the onset of leg weakness, which reveals the rapid progression of untreated cases. To our knowledge, this is the first case of spinal cord PNET with parenchymal involvement that has been described in an infant. 相似文献
82.
Suprathreshold Auditory Cortex Activation Visualized by Intrinsic Signal Optical Imaging 总被引:2,自引:2,他引:0
Bakin Jonathan S.; Kwon Michael C.; Masino Susan A.; Weinberger Norman M.; Frostig Ron D. 《Cerebral cortex (New York, N.Y. : 1991)》1996,6(2):120-130
The suprathreshold tonotopic organization of rat and guineapig auditory cortex was investigated using intrinsic signaloptical imaging through a thinned skull. Optical imaging revealedthat suprathreshold pure sine wave tone stimulation (2540dB) evoked activity over large cortical areas that were tonotopicallyorganized. Three-dimensional surface plots of the activatedareas revealed "patchy" auditory-evoked activity consistingof numerous local peaks and valleys building to a maximum. Subsequentdetailed electrophysiological mapping in the same subjects confirmedthe localization of auditory-evoked activity based on opticalimaging, including responses to a test frequency at corticalloci more than 2 octaves away from the threshold-defined isofrequencycontour. The success of this technique in visualizing auditorycortex functional organization at suprathreshold stimulus levelswill allow for future investigations of auditory cortex frequencyrepresentation. including representational plasticity inducedby a variety of experimental manipulations. 相似文献
83.
E M Sadeghi L L Weldon P H Kwon E Sampson 《International journal of oral and maxillofacial surgery》1991,20(3):142-143
This unusual cystic lesion was previously described as a lesion that has features of both botryoid odontogenic cyst and mucoepidermoid tumor and later was named as glandular odontogenic cyst. An additional case is reported and its clinicopathologic features described. The name "mucoepidermoid odontogenic cyst" is proposed. 相似文献
84.
Hirayasu Y McCarley RW Salisbury DF Tanaka S Kwon JS Frumin M Snyderman D Yurgelun-Todd D Kikinis R Jolesz FA Shenton ME 《Archives of general psychiatry》2000,57(7):692-699
BACKGROUND: Magnetic resonance imaging studies in schizophrenia have revealed abnormalities in temporal lobe structures, including the superior temporal gyrus. More specifically, abnormalities have been reported in the posterior superior temporal gyrus, which includes the Heschl gyrus and planum temporale, the latter being an important substrate for language. However, the specificity of the Heschl gyrus and planum temporale structural abnormalities to schizophrenia vs affective psychosis, and the possible confounding roles of chronic morbidity and neuroleptic treatment, remain unclear. METHODS: Magnetic resonance images were acquired using a 1.5-T magnet from 20 first-episode (at first hospitalization) patients with schizophrenia (mean age, 27.3 years), 24 first-episode patients with manic psychosis (mean age, 23.6 years), and 22 controls (mean age, 24.5 years). There was no significant difference in age for the 3 groups. All brain images were uniformly aligned and then reformatted and resampled to yield isotropic voxels. RESULTS: Gray matter volume of the left planum temporale differed among the 3 groups. The patients with schizophrenia had significantly smaller left planum temporale volume than controls (20.0%) and patients with mania (20.0%). Heschl gyrus gray matter volume (left and right) was also reduced in patients with schizophrenia compared with controls (13.1%) and patients with bipolar mania (16.8%). CONCLUSIONS: Compared with controls and patients with bipolar manic psychosis, patients with first-episode schizophrenia showed left planum temporale gray matter volume reduction and bilateral Heschl gyrus gray matter volume reduction. These findings are similar to those reported in patients with chronic schizophrenia and suggest that such abnormalities are present at first episode and are specific to schizophrenia. 相似文献
85.
To correct crooked nail deformity, which results from the partial loss of the distal phalanx, soft-tissue restoration alone is usually not enough to restore the length and shape of the nail structure. The authors treated 10 crooked nail fingertips by modified osteoplastic reconstruction, which included the elevation of the dorsally based volar skin flap and an iliac bone graft covered by an adequate skin flap. During the postoperative follow-up, the nail straightened, although not to the preinjury extent, along the restored distal phalanx with bony support. The authors' osteoplastic reconstruction, which involves the enhancement of the fingertips with composite tissues, presents a practical method for the correction of crooked nail deformity. 相似文献
86.
Kaibori M Sakakura Y Oda M Okumura T Kwon AH Kamiyama Y 《Transplantation proceedings》2000,32(7):2285-2286
87.
Tomas Norlander Sam-Hyun Kwon Gert Henriksson Karl Magnus Westrin Karin Sandstedt Pontus Stierna 《The Laryngoscope》1998,108(3):411-417
To investigate possible effects of corticosteroids on polyp formation and local bacterial colonization, pneumococcal sinusitis was experimentally induced in rabbits pretreated with betamethasone or saline. After 7 days, macroscopic polyps were counted post-mortem and on histologic slides after serial sectioning. Histologic sections were also examined with light microscopy. Macroscopic polyps were significantly fewer in animals given betamethasone, while there was no difference regarding the number of microscopic polyps. Ingrowth of pathogenic microorganisms was found in five of eight rabbits given placebo but in none of the animals treated with corticosteroids (P < 0.05). The reduced number of pathogenic strains in these animals may be explained by a better-preserved local host defense. The lower number of macroscopic polyps in the same animals could be because of a delayed mucosal repair and subsequent polyp formation. 相似文献
88.
Han DH Kwon OK Byun BJ Choi BY Choi CW Choi JU Choi SG Doh JO Han JW Jung S Kang SD Kim DJ Kim HI Kim HD Kim MC Kim SC Kim SC Kim Y Kwun BD Lee BG Lim YJ Moon JG Park HS Shin MS Song JH Suk JS Yim MB;Korean Society for Cerebrovascular Disease 《Acta neurochirurgica》2000,142(11):1263-73; discussion 1273-4
A co-operative study was conducted to determine the clinical characteristics of patients with moyamoya disease who were diagnosed and treated at neurosurgical institutes in Korea before 1995. Twenty-six hospitals contributed 505 cases and among them, the clinical characteristics of 334 patients with definite moyamoya disease were evaluated. The number of patients began to increase from the late 1980s, and after that approximately 20 patients were treated each year. There were two age peaks: from six to 15 and from 31 to 40 years of age. Haemorrhagic manifestations occurred in approximately 43% of the patients. The major clinical manifestations were haemorrhage in adults (62.4%) and ischaemia in children (61.2%). Overall 54.5% of the patients experienced decreased consciousness levels, mainly due to intracranial haemorrhage or cerebral infarction. In the patients with ischemic manifestations, the adult patients were more likely to have cerebral infarction than the pediatric patients (80% vs. 39%) and the pediatric patients were more likely to have TIA (61% vs. 25%). Thirty eight percent of the patients underwent bypass surgery and 53% of these procedures were performed bilaterally. Treatment policies, including indications for bypass surgery and commonly used drugs, were somewhat different according to the institution. Overall favorable outcome was 73%, and the most significant factor affecting poor outcome was haemorrhagic manifestation. This article describes the characteristics of 334 patients with moyamoya disease, who were diagnosed and treated at neurosurgical institutes in Korea before 1995. 相似文献
89.
Chen-Bee CH Polley DB Brett-Green B Prakash N Kwon MC Frostig RD 《Journal of neuroscience methods》2000,97(2):157-173
Intrinsic signal imaging (ISI) measures changes in light reflectance from the illuminated cortex (intrinsic signals or IS) attributed to various vascular and metabolic sources that, when using illumination in the 600 nm range, appear to co-localize with neuronal activity. Given the multiple sources contributing to the collected IS, the common practice of averaging across an extended post-stimulus time epoch before dividing by baseline data typically visualizes evoked IS overlying both the cortical tissue and the large surface blood vessels. In rat PMBSF, the contribution from these vessels are problematic as they do not co-localize with known PMBSF function. Determining a means for quantifying the evoked IS area poses an additional challenge. Here, we describe how exploiting IS collected shortly after stimulus onset (within 1.5 s), which coincides with fast oxygen consumption of active neurons, visualizes evoked IS overlying the cortical tissue without the large surface vessels. We also describe how the use of absolute thresholds combined with a baseline determined from data collected immediately prior to stimulus onset (within 1 s) targets most precisely a specific evoked IS amplitude, a method that should be especially useful when evoked areas are expected to occupy a substantial portion of the total imaged area and/or when peak activity is expected to differ between subjects. 相似文献
90.
Ha CM Kang JH Choi EJ Kim MS Park JW Kim Y Choi WS Chun SY Kwon HB Lee BJ 《Brain research. Molecular brain research》2000,78(1-2):59-68
Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates pituitary hormone biosynthesis and secretion through its cognate receptors. PACAP also plays an important role in the regulation of ovarian steroid biosynthesis. If so, there might be a feedback regulation of hypothalamic PACAP synthesis by the pituitary and by ovarian steroids. In the present study, we used RNase protection assays to determine changes in mRNA levels of PACAP and type I PACAP receptor (PAC(1)) under the conditions of ovariectomy and replacement with ovarian steroids. Progesterone (P) alone or in combination with estradiol (E) induced significant increases in PACAP mRNA level in the medial basal hypothalamus (MBH) and PAC(1) mRNA levels in MBH and the preoptic area (POA). This finding suggests that feedback regulation takes place between the ovary and hypothalamic PACAP neurons. P is known to be a major regulatory feedback factor for hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons, but P receptor is not present in these neurons. Therefore, we examined a possible involvement of PACAP in the feedback regulatory pathway of P to LHRH neurons. After an antisense PAC(1) oligodeoxynucleotide (ODN) was i.c.v.-injected into the third ventricle of E and P-treated rats, LHRH mRNA levels were determined. The ODN markedly decreased the P-induced increase in the LHRH mRNA level. Taken together, the present data suggest that PACAP may play a role as a mediator in the regulation of LHRH synthetic machinery by stimulatory feedback of P. 相似文献