全文获取类型
收费全文 | 578篇 |
免费 | 27篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 71篇 |
口腔科学 | 4篇 |
临床医学 | 22篇 |
内科学 | 142篇 |
皮肤病学 | 4篇 |
神经病学 | 41篇 |
特种医学 | 2篇 |
外科学 | 110篇 |
预防医学 | 8篇 |
眼科学 | 10篇 |
药学 | 108篇 |
中国医学 | 2篇 |
肿瘤学 | 75篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 3篇 |
2021年 | 12篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 22篇 |
2017年 | 11篇 |
2016年 | 8篇 |
2015年 | 14篇 |
2014年 | 28篇 |
2013年 | 32篇 |
2012年 | 53篇 |
2011年 | 36篇 |
2010年 | 27篇 |
2009年 | 21篇 |
2008年 | 40篇 |
2007年 | 34篇 |
2006年 | 27篇 |
2005年 | 27篇 |
2004年 | 35篇 |
2003年 | 27篇 |
2002年 | 32篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 8篇 |
1998年 | 8篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 13篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1972年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有606条查询结果,搜索用时 15 毫秒
61.
Shimokata K Katayama Y Murayama H Suematsu M Tsukihara T Muramoto K Aoyama H Yoshikawa S Shimada H 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(10):4200-4205
X-ray structures of bovine heart cytochrome c oxidase have suggested that the enzyme, which reduces O(2) in a process coupled with a proton pumping process, contains a proton pumping pathway (H-pathway) composed of a hydrogen bond network and a water channel located in tandem across the enzyme. The hydrogen bond network includes the peptide bond between Tyr-440 and Ser-441, which could facilitate unidirectional proton transfer. Replacement of a possible proton-ejecting aspartate (Asp-51) at one end of the H-pathway with asparagine, using a stable bovine gene expression system, abolishes the proton pumping activity without influencing the O(2) reduction function. Blockage of either the water channel by a double mutation (Val386Leu and Met390Trp) or proton transfer through the peptide by a Ser441Pro mutation was found to abolish the proton pumping activity without impairment of the O(2) reduction activity. These results significantly strengthen the proposal that H-pathway is involved in proton pumping. 相似文献
62.
Iseki K 《Nihon rinsho. Japanese journal of clinical medicine》2008,66(9):1650-1656
Concept of chronic kidney disease (CKD) is widely accepted, since it is a risk factor for end-stage renal disease (ESRD) and cardiovascular disease. In Japan, the prevalence of ESRD is increasing and is currently more than 2,000 per million populations. More than 40% of incident ESRD is due to diabetes mellitus. The prevalence of a low glomerular filtration rate (GFR < 60 mL/min/1.73 m2) is estimated to be 10% of the adult population. Studies based on several community-based screening programs suggest that Japan has a higher prevalence of CKD than any other countries. Early detection through urine test for proteinuria and measurement of serum creatinine is strongly recommended. Goal of treatment of CKD is to decrease the incidence of ESRD and cardiovascular disease. 相似文献
63.
64.
Longitudinal neuroendocrine changes assessed by dexamethasone/CRH and growth hormone releasing hormone tests in psychotic depression 总被引:1,自引:0,他引:1
Owashi T Otsubo T Oshima A Nakagome K Higuchi T Kamijima K 《Psychoneuroendocrinology》2008,33(2):152-161
Although psychotic depression has been reported to exhibit a greater degree of dysregulation of hypothalamic-pituitary-adrenocortical (HPA) function than non-psychotic depression, little is known concerning hypothalamic-pituitary-somatotropic (HPS) function in psychotic depression and how neuroendocrine function changes after treatment. To investigate the longitudinal changes in HPA and HPS system function in psychotic depression, we performed repeated dexamethasone/corticotropin releasing hormone (DEX/CRH) tests and growth hormone (GH) releasing hormone (GHRH) tests in inpatients with major depressive disorder. The psychotic depression group exhibited greater elevation of ACTH responses to the DEX/CRH test and stronger decreases in GH responses to the GHRH test than the non-psychotic depression group at admission. At discharge, the neuroendocrine responses to the DEX/CRH test of the psychotic depression group were still stronger than those of the non-psychotic depression group, though there were no significant differences in severity of depression between the groups. There were significant longitudinal changes in neuroendocrine responses to the DEX/CRH test between admission and discharge. The psychotic depression group exhibited increased GH responses to GHRH at discharge compared with those at admission, whereas no significant longitudinal change in GH response was found in the non-psychotic depression group. Consequently, there were no significant differences in GH responses to GHRH between the psychotic and non-psychotic depression groups at discharge. The results of GHRH test showed no significant relationships with severity of depression except psychotic features and the results of the DEX/CRH test. Our findings suggest that the HPS axis may be associated with psychotic features rather than general severity of depression. Further longitudinal studies are needed to clarify the role of HPS function in psychotic depression and whether sustained dysregulation of HPA function in psychotic depression is associated with a poor outcome after discharge. 相似文献
65.
Iseki K 《Kidney international》2008,74(4):415-417
Women live longer than men. Can this phenomenon be explained by chronic kidney disease (CKD)? Gender differences in the prevalence and incidence of CKD are discussed. 相似文献
66.
Comparison of clinical and pathological features of lung lesions of systemic IgG4‐related disease and idiopathic multicentric Castleman's disease
下载免费PDF全文
![点击此处可从《Histopathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Yasuhiro Terasaki Soichiro Ikushima Shoko Matsui Akira Hebisawa Yasunori Ichimura Shinyu Izumi Masuo Ujita Machiko Arita Keisuke Tomii Yuko Komase Isoko Owan Tetsuji Kawamura Yasuo Matsuzawa Miho Murakami Hiroshi Ishimoto Hiroshi Kimura Masashi Bando Norihiro Nishimoto Yoshinori Kawabata Yuh Fukuda Takashi Ogura the Tokyo Diffuse Lung Diseases Study Group 《Histopathology》2017,70(7):1114-1124
67.
Y Nambu T Iwata K Oida Y Kohri Y Taguchi K Tomii M Mino Y Yunoki K Ichijima Y Kobashi 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(6):734-739
A 54-year-old woman under treatment for rheumatoid arthritis was admitted because of aggravation of dyspnea on effort and restrictive pulmonary dysfunction. Although chest X-ray revealed no marked change, the symptoms progressively worsened, necessitating open lung biopsy for diagnosis and treatment. Based on the histopathological findings of the biopsied tissue, the patient was diagnosed as having active rheumatoid lung complicated with cellular interstitial pneumonia and follicular bronchiolitis. The patient responded well to adrenocorticosteroid and immunosuppressor therapy, and is now being followed up as an outpatient. Rheumatoid arthritis can be complicated by diverse lung diseases. Among them one important disease is interstitial pneumonia, which serves as a prognostic factor. When cellular interstitial pneumonia is treated with adrenocorticosteroid therapy, it responds well and its prognosis is good. Therefore, its early detection and appropriate adrenocortical therapy are essential. Patients with rheumatoid arthritis presenting with dyspnea on effort and pulmonary dysfunction should be examined for cellular interstitial pneumonia, follicular bronchiolitis and other lung diseases, even when no marked change is visible on chest X-ray films. 相似文献
68.
Y Nambu T Iwata K Oida Y Kohri Y Taguchi K Tomii M Mino Y Yunoki K Ichijima Y Kobashi 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(10):1275-1281
In order to investigate the etiology of usual interstitial pneumonia (UIP) and UIP with lung cancer (LC), autopsy findings in 18 cases of UIP with LC and 11 cases of uncomplicated UIP were clinicopathologically compared with the environmental factors of smoking habits and occupation. UIP with LC was highly correlated with smoking, especially heavy smoking and with occupations in which dust is inhaled, such as electrical installation and ceramic production, indicating that these environmental factors are important background factors in the complication of UIP with IC. Pathologic examination of cases of UIP with LC (6 squamous cell carcinomas, 5 small cell carcinomas, 4 adenocarcinomas, and 3 large cell carcinomas, 2 of which showed pulmonary double carcinoma revealing a slight correlation between fibrosis and primary site of LC and a slightly greater correlation of squamous cell carcinoma and small cell carcinoma to smoking habits and inhalation of dust. In terms of the correlation between UIP and LC among autopsy cases, the environmental factors proved to be more significant than the fibrotic findings. These environmental factors are thought to merit consideration as common predisposing factors in the development of LC and its complication with UIP. 相似文献
69.
70.