全文获取类型
收费全文 | 1507篇 |
免费 | 46篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 76篇 |
妇产科学 | 36篇 |
基础医学 | 254篇 |
口腔科学 | 12篇 |
临床医学 | 90篇 |
内科学 | 269篇 |
皮肤病学 | 13篇 |
神经病学 | 212篇 |
特种医学 | 14篇 |
外科学 | 99篇 |
综合类 | 5篇 |
预防医学 | 92篇 |
眼科学 | 61篇 |
药学 | 197篇 |
中国医学 | 2篇 |
肿瘤学 | 85篇 |
出版年
2022年 | 10篇 |
2021年 | 30篇 |
2020年 | 10篇 |
2019年 | 17篇 |
2018年 | 26篇 |
2017年 | 23篇 |
2016年 | 26篇 |
2015年 | 24篇 |
2014年 | 39篇 |
2013年 | 53篇 |
2012年 | 92篇 |
2011年 | 103篇 |
2010年 | 71篇 |
2009年 | 49篇 |
2008年 | 89篇 |
2007年 | 119篇 |
2006年 | 109篇 |
2005年 | 111篇 |
2004年 | 109篇 |
2003年 | 109篇 |
2002年 | 104篇 |
2001年 | 7篇 |
2000年 | 6篇 |
1999年 | 7篇 |
1998年 | 18篇 |
1996年 | 11篇 |
1995年 | 13篇 |
1994年 | 7篇 |
1993年 | 8篇 |
1992年 | 13篇 |
1991年 | 8篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 6篇 |
1983年 | 10篇 |
1982年 | 12篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1972年 | 7篇 |
1971年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有1557条查询结果,搜索用时 31 毫秒
131.
132.
Kinga Musiał Krystyna Szprynger Maria Szczepańska Danuta Zwolińska 《Pediatric nephrology (Berlin, Germany)》2009,24(10):2029-2034
Chronic inflammation, lipid and autoimmune disorders are hallmarks of atherogenesis, and hemodialysis per se may be an additional
factor predisposing to accelerated atherosclerosis. Elevated levels of heat shock proteins (HSP) and antibodies against these
HSP have been described in adults with atherosclerotic lesions and cardiovascular events, but to date there has been a scarcity
of investigations on these parameters in adult and pediatric patients on hemodialysis (HD). We have investigated the HSP profile
in hemodialyzed children and the impact of a single HD session on those proteins and their correlations with known risk factors
for atherosclerosis. The study group consisted of 17 children and young adults undergoing HD with polysulfone membranes. The
control group comprised 15 age-matched subjects with normal kidney function. The serum concentrations of Hsp60, Hsp90alpha,
anti-Hsp60, anti-Hsp70, and sE-selectin were assessed by an enzyme-linked immunosorbent assay, and serum concentration of
high-sensitivity-C-reactive protein was assayed by nephelometry. The serum lipid profile [total cholesterol (CHOL), high-density
lipoprotein-CHOL, low-density lipoprotein-CHOL, triglycerides] was also estimated. Compared to the control values, the median
values of Hsp60 before the HD session were lower, whereas those of Hsp90alpha and anti-Hsp60 were higher. A single HD session
raised the median values of Hsp60 and Hsp90alpha and decreased the concentrations of anti-Hsp60 and anti-Hsp70. In addition,
the concentrations of HSPs and the antibodies against them correlated with the lipid markers both before and after HD. The
altered HSP and anti-HSP concentrations in HD children, which correlated with the lipid profile and the endothelial markers,
suggest a dysfunctional HSP system in this population and the possibility of HSPs being classified as new markers of atherosclerosis. 相似文献
133.
134.
Zygmunt Wyrzykowski Barbara Przybylska Krystyna Wyrzykowska 《Journal of pineal research》1987,4(2):125-134
The pineal glands of pregnant and nursing sows were studied by light and electron microscopy. Similar structural changes in the pineal gland during pregnancy and lactation were noted as follows: a proliferation of glial cells concurrent with a decrease in the number of pinealocytes, a relative increase in the number of pinealocytes with cytoplasmic accumulation of dense bodies, and an increase in number of presumptive microglia. It appears that pregnancy and lactation exert a complex influence on pineal function, with a predominantly stimulating effect. 相似文献
135.
Jolanta Malyszko Maria Mazerska Jacek Malyszko Krystyna Pawlak Arsalan Azzadin Michal Mysliwiec Wlodzimierz Buczko 《International Journal of Clinical & Laboratory Research》1993,23(1-4):42-44
Summary Recombinant human erythropoietin was administered to 12 patients with end-stage renal failure on long-term hemodialysis. They
responded to the therapy with a shortening of the prolonged bleeding time, starting from the 1st week of therapy, before a
significant increase in hemoglobin concentration was achieved. We also observed an increase in the activity of tissue plasminogen
activator and a decrease in the activity of its inhibitor. There were no changes in platelet count but a significant increase
in blood and platelet serotonin concentration was found. The shortening of the prolonged bleeding time before the correction
of the anemia correlated with the rise in blood and platelet serotomin concentration during erythropoietin therapy. We suggest
the possible involvement of an serotonergic mechanism in the hemostatic action of recombinant human erythropoietin. 相似文献
136.
Pruszczyk P Bochowicz A Kostrubiec M Torbicki A Szulc M Gurba H Kuczynska K Berent H 《Clinica chimica acta; international journal of clinical chemistry》2003,338(1-2):53-56
BACKGROUND: Concentrations of cardiac troponins can be elevated in acute pulmonary embolism (APE) indicating myocardial injury. Although concentration of myoglobin (MYO) increases after myocardial damage, even before detectable rise of cardiac troponin levels occurs, MYO was not evaluated in APE. Therefore, we assessed prevalence and prognostic significance of myoglobin in major APE. METHODS: We studied 46 patients (30 women, aged 61.9+/-17.8 years) with major APE defined with right ventricular dilatation. On admission serum myoglobin, and cardiac troponin T (cTnT) were measured. Serum MYO concentrations >58 ng/ml for women, and >72 ng/ml for men were considered abnormal. CTnT>0.01 ng/ml was regarded to indicate myocardial injury. RESULTS: MYO levels exceeding sex specific norms were found in 21/46 (45.7%) of patients, while detectable cTnT was found in 24/46 (52.1%) of patients. Seven patients died during hospitalization. Elevated MYO significantly predicted in-hospital mortality (OR 25, 95% CI 1.3-474.2), while increased cTnT concentration did not affect the survival. Among clinical and echocardiographic variables only older age indicated worse prognosis (OR 1.6, 95% CI 1.06-2.41). CONCLUSIONS: Myoglobin levels are elevated in serum on admission in almost half of patients with major APE. Elevated myoglobin level, marker of myocardial injury, is a powerful predictor of increased risk of fatal outcome in major pulmonary embolism. 相似文献
137.
James A. Karlowsky Douglas J. Biedenbach Krystyna M. Kazmierczak Gregory G. Stone Daniel F. Sahm 《Antimicrobial agents and chemotherapy》2016,60(5):2849-2857
The in vitro activity of ceftazidime-avibactam was evaluated against 34,062 isolates of Enterobacteriaceae from patients with intra-abdominal, urinary tract, skin and soft-tissue, lower respiratory tract, and blood infections collected in the INFORM (International Network For Optimal Resistance Monitoring) global surveillance study (176 medical center laboratories in 39 countries) in 2012 to 2014. Overall, 99.5% of Enterobacteriaceae isolates were susceptible to ceftazidime-avibactam using FDA approved breakpoints (susceptible MIC of ≤8 μg/ml; resistant MIC of ≥16 μg/ml). For individual species of the Enterobacteriaceae, the ceftazidime-avibactam MIC inhibiting ≥90% of isolates (MIC90) ranged from 0.06 μg/ml for Proteus species to 1 μg/ml for Enterobacter spp. and Klebsiella pneumoniae. Carbapenem-susceptible isolates of Escherichia coli, K. pneumoniae, Klebsiella oxytoca, and Proteus mirabilis with a confirmed extended-spectrum β-lactamase (ESBL) phenotype, or a ceftazidime MIC of ≥16 μg/ml if the ESBL phenotype was not confirmed by clavulanic acid inhibition, were characterized further to identify the presence of specific ESBL- and plasmid-mediated AmpC β-lactamase genes using a microarray-based assay and additional PCR assays. Ceftazidime-avibactam demonstrated potent activity against molecularly confirmed ESBL-producing (n = 5,354; MIC90, 0.5 μg/ml; 99.9% susceptible), plasmid-mediated AmpC-producing (n = 246; MIC90, 0.5 μg/ml; 100% susceptible), and ESBL- and AmpC-producing (n = 152; MIC90, 1 μg/ml; 100% susceptible) isolates of E. coli, K. pneumoniae, K. oxytoca, and P. mirabilis. We conclude that ceftazidime-avibactam demonstrates potent in vitro activity against globally collected clinical isolates of Enterobacteriaceae, including isolates producing ESBLs and AmpC β-lactamases. 相似文献
138.
139.
K Salat T Librowski A Moniczewski K Stanisz-Wallis K Wieckowski B Malawska 《Behavioural pharmacology》2012,23(4):407-416
In this paper, the analgesic, antioedematous, motor-impairing and antioxidant properties of four γ-butyrolactone derivatives (BM113, BM113A, BM138 and BM138A) are described. Pain was induced by thermal (hot-plate test), chemical (writhing test) or mechanical (Randall-Selitto model) stimulation. All in-vivo assays were carried out in mice pretreated intraperitoneally with the test compounds, except for the evaluation of anti-inflammatory and analgesic activities in the carrageenan-induced paw oedema model, in which rats were pretreated orally with these compounds. In the hot-plate assay, BM113A and BM138A dose dependently prolonged the latency of the nociceptive reaction. Their analgesic activity, measured as a median effective dose (ED(50)=4.7 mg/kg), was similar to that of morphine (2.4 mg/kg). In the writhing test, all four compounds, in particular BM113A and BM138A, showed higher potency than the reference drug acetylsalicylic acid (the ED(50) values were 3.7, 2.3 and 46.1 mg/kg, respectively). BM138 caused a dose-dependent diminution of paw oedema (up to 49%) in the carrageenan model and BM138A at 200 mg/kg reduced mechanical hyperalgesia in the Randall-Selitto test (~30% when compared with the control). None of the γ-butyrolactone derivatives tested at the ED(50) obtained in the hot-plate test influenced the locomotor activity of mice, although in the rotarod test at 24 rpm, BM113A and BM138 at 100 mg/kg showed some motor-impairing properties. In vitro, a concentration-dependent ABTS radical cation-scavenging activity of BM138 and BM138A (up to 80% inhibition of the radical absorbance) was observed. The results of the present study suggest that BM138 and BM138A could be of interest for future investigations as antinociceptive and antioedematous agents with potential free radical-scavenging properties. 相似文献
140.
The synthesis and biological activity of new conjugates of muramyl dipeptide (MDP) and nor-muramyl dipeptide (nor-MDP) with tuftsin and retro-tuftsin derivatives containing isopeptide bond between ε-amino group of lysine and carboxyl group of simple amino acids such as Ala, Gly and Val are presented. We presumed, based on the cytokine profile, that the examined conjugates of tuftsin and MDP were capable of activating antibacterial mechanisms by switching on Th1 immune response. The most active were compounds 11, 14 and 19-23. 相似文献