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Hidetaka Imagita Akira Nishikawa Susumu Sakata Yasue Nishii Akira Minematsu Hideki Moriyama Naohiko Kanemura Hanae Shindo 《Journal of Physical Therapy Science》2015,27(3):791-794
[Purpose] The purpose of this study was to make an experimental model of cervical spinal
cord injury (CSCI) using Wistar rats, in order to analyze the influence of CSCI on the
respiratory function. [Subjects] Thirty-two male 12-week-old Wistar rats were used.
[Methods] The CSCI was made at the levels from C3 to C7, and we performed
pneumotachography and electromyography (EMG) on the diaphragm. Computed tomography was
used to determine the level of spinal cord damage. [Results] After the operation, the
tidal volume of the rats with a C3 level injury decreased to approximately 22.3% of its
pre-injury value. In addition, in the same rats, the diaphragmatic electromyogram activity
decreased remarkably. Compared with before CSCI, the tidal volume decreased to 78.6% of
its pre-injury value in CSCI at the C5 level, and it decreased to 94.1% of its pre-injury
value in CSCI at the C7 level. [Conclusion] In the rats that sustained a CSCI in this
study, the group of respiratory muscles that receive innervation from the thoracic spinal
cord was paralyzed. Therefore, the EMG signal of the diaphragm increased. These results
demonstrate that there is a relationship between respiratory function and the level of
CSCI.Key words: Cervical spinal cord injury, Respiratory function, Electromyography of diaphragm muscle 相似文献
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Ryuichi Yoshimura Ryohei Yamamoto Maki Shinzawa Ryohei Tomi Shingo Ozaki Yoshiyuki Fujii Takafumi Ito Kazuaki Tanabe Yasuaki Moriguchi Yoshitaka Isaka Toshiki Moriyama 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(4):649-655
Salt sensitivity is one of the crucial risk factors of hypertension. The aim of the present prospective cohort study was to assess the clinical impact of alcohol drinking on an association between salt intake and blood pressure. The present study included 451 employees at a pharmaceutical company in Japan who underwent annual health checkups in both 2017 and 2018. The main exposure of interest was self‐reported drinking frequency at their first checkups: rarely, occasionally, and daily. To assess the association between the change of salt intake estimated from single‐spot urine specimens and that of blood pressure, the differences in systolic/diastolic blood pressure and salt intake between 2017 and 2018 were calculated for each subject. Multivariable‐adjusted linear regression models adjusting for clinically relevant factors clarified a drinking frequency‐dependent association between Δsalt intake and Δsystolic blood pressure (per 1 g/d of Δsalt intake adjusted β [95% confidence interval] 0.19 [−0.73, 1.12], 0.84 [0.14, 1.53], and 1.78 [0.86, 2.69] in rare, occasional, and daily drinkers). A similar association between Δsalt intake and Δdiastolic blood pressure was also observed (−0.24 [−1.02, 0.54], 0.67 (0.18, 1.16), 0.95 [0.38, 1.51], in rare, occasional, and daily drinkers). The interactions between drinking frequency and Δsalt intake were found to be statistically significant (P for interaction = .028 and .006 for ∆systolic blood pressure and ∆diastolic blood pressure, respectively). The present study identified enhanced salt sensitivity in the subjects who drink at a higher frequency, suggesting that the reduction in alcohol consumption may improve salt sensitivity in higher frequency drinkers. 相似文献
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