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61.
Masami Imakita Chikao Yutani Hatsue Ishibashi-Ueda Masayoshi Murakami Yoshihide Chiba 《Pathology international》1988,38(7):941-945
A case of an infant born in association with a large chorioangioma of the placenta is reported. The mother was complicated with polyhydramnios and premature labor. The fetal complications were congestive heart failure and hydrops fetalis. This case serves to emphasize that it is necessary to examine the placenta in every perinatal autopsy case. ACTA PATHOL JPN 38: 941∼945, 1988. 相似文献
62.
Yoshimasa Seike Hitoshi Matsuda Hatsue Ishibashi-Ueda Hiroko Morisaki Takayuki Morisaki Kenji Minatoya Hitoshi Ogino 《Annals of thoracic and cardiovascular surgery》2021,27(1):56
Purpose: To identify differences in surgical outcomes between patients with transforming growth factor-beta receptor (TGFBR) 1 and TGFBR2 mutations in Loeys-Dietz syndrome (LDS).Methods: In all, 22 LDS patients between 1998 and 2015 were divided into the two groups: TGFBR1 (n = 11) and TGFBR2 mutation (n = 11).Results: The freedom from aortic reoperation was similar between the two groups (p = 0.19, log-rank). In the subanalysis, the freedom from aortic reoperation was lower in female patients with TGFBR2 mutations (n = 6) than in other patients (p = 0.08). The freedom from aortic dissection (AD) after the initial surgery was also lower in female patients with TGFBR2 mutation than in other patients (p = 0.025). All patients with TGFBR2 mutations revealed grade III cystic medial necrosis (CMN), whereas 67% of patients with TGFBR1 mutations showed CMN (p = 0.033) and only one patient had grade III (p <0.001).Conclusion: LDS patients with TGFBR2 mutations had higher grade of CMN than those of TGFBR1 mutations. In particular, in female patients with TGFBR2 mutations, AD after the initial surgery and reoperation were more frequent than those of other LDS patients. 相似文献
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64.
Osamu Seguchi Tomoyuki Fujita Yoshihiro Murata Haruki Sunami Takuma Sato Takuya Watanabe Seiko Nakajima Kensuke Kuroda Eriko Hisamatsu Takamasa Sato Masanobu Yanase Hiroki Hata Kyoichi Wada Hatsue Ishibashi-Ueda Junjiro Kobayashi Takeshi Nakatani 《Heart and vessels》2016,31(4):555-562
Donor and recipient characteristics, as well as donor–recipient matching, affect clinical outcomes after heart transplantation (HTx). This study aimed to clarify how donor and recipient characteristics affect the clinical course after HTx. The medical records of all the patients who underwent HTx at the National Cerebral and Cardiovascular Center from 1999 to 2014 were retrospectively reviewed. Sixty-one patients (48 males) underwent HTx. Six recipients (9.8 %) developed primary graft dysfunction (PGD) determined by criteria recently established at a consensus conference. Development of PGD was associated with high-dose inotropic support for the donor heart and a history of stroke in the recipient (p = 0.04 and p = 0.002, respectively). Recipients with PGD had higher right atrial pressure (RAP) and lower cardiac output (CO) compared with those without PGD at 6 months after HTx (RAP, 6.8 ± 3.6 vs. 2.8 ± 2.2 mmHg, p < 0.001; CO, 4.6 ± 0.8 l vs. 5.8 ± 1.2 l/min, p = 0.02). With respect to survival, patients with PGD had a 5-year survival rate equivalent to those without PGD (83.3 vs. 93.3 %, p = 0.23). High-dose inotropic support for the donor heart and a history of stroke in the recipient are significant predictive factors for the development of PGD. However, recipients with PGD demonstrate mid-term survival comparable to those without PGD. 相似文献
65.
Kodama Kenichiro Kawaoka Tomokazu Kosaka Masanari Johira Yusuke Shirane Yuki Miura Ryoichi Yano Shigeki Murakami Serami Amioka Kei Naruto Kensuke Ando Yuwa Kosaka Yumi Uchikawa Shinsuke Fujino Hatsue Nakahara Takashi Murakami Eisuke Okamoto Wataru Yamauchi Masami Miki Daiki Imamura Michio Kuroda Shintaro Kobayashi Tsuyoshi Ohdan Hideki Aikata Hiroshi Chayama Kazuaki 《Journal of gastroenterology》2022,57(9):676-683
Journal of Gastroenterology - Intrahepatic cholangiocarcinoma is the second most common primary cancer of the liver. It is highly malignant and its prognosis is very poor. Although there have been... 相似文献
66.
Yuno Nishida Tomokazu Kawaoka Michio Imamura Maiko Namba Yasutoshi Fujii Shinsuke Uchikawa Kazuki Ohya Kana Daijo Yuji Teraoka Kei Morio Hatsue Fujino Takashi Nakahara Masami Yamauchi Akira Hiramatsu Masataka Tsuge Hiroshi Aikata Shoichi Takahashi C. Nelson Hayes Takayuki Fukuhara Keiji Tsuji Keiko Arataki Yuko Nagaoki Yasuyuki Aisaka Koji Kamada Hideaki Kodama Kazuaki Chayama 《Internal medicine (Tokyo, Japan)》2021,60(6):829
Objective Lusutrombopag is a thrombopoietin receptor agonist that improves thrombocytopenia in patients with chronic liver disease scheduled to undergo invasive procedures. However, information on the efficacy of repeated lusutrombopag treatment and factors associated with the treatment is scarce. We analyzed the efficacy of repeated lusutrombopag treatment and the factors associated with a response to lusutrombopag. Methods Thirty-nine patients with chronic liver disease who received lusutrombopag treatment before undergoing invasive procedures were enrolled in this retrospective study. Of the 39 patients, 10 received lusutrombopag treatment multiple times for a total of 53 regimens of lusutrombopag treatment. Changes in platelet counts, the effects of repeated lusutrombopag treatment, and factors associated with response to lusutrombopag were analyzed. Results The median platelet count increased significantly from 4.5×104/μL before lusutrombopag treatment to 7.2×104/μL before the invasive procedure (p<0.01), and patients undergoing 49 of the 53 (92%) treatment regimens succeeded in undergoing invasive procedures without needing platelet transfusions. In patients who received lusutrombopag treatment repeatedly, the median platelet count significantly increased following the second administration of lusutrombopag, and the effects of lusutrombopag were similar between the first and second administration. A multivariate analysis identified the absence of diabetes mellitus (odds ratio, 5.56 for presence; p=0.04) as a significant and independent predictor of a response to lusutrombopag. Conclusion Lusutrombopag treatment significantly increased platelet counts in patients with chronic liver disease, making it possible to receive invasive procedures. The treatment produced identical effects when it was repeated. The efficacy of lusutrombopag might be decreased in patients with diabetes mellitus. 相似文献
67.
68.
Dr. Emi Odagiri M.D. Kazuko Jibiki Reiko Demura M.D. Hatsue Shinozaki Saeko Nakamura Hiroshi Demura M.D. Hirotaka Suzuki M.D. 《Diseases of the colon and rectum》1984,27(12):787-791
Twenty-five colonic cancer tissues were studied for the presence of estrogen and progesterone receptors (ER, PR) and the distribution
of immunoreactive carcinoembryonic antigen (IR-CEA). ER and PR were determined in 6 (24 per cent) and 3 (12 per cent), respectively,
of 25 patients with colonic cancer. Of the six patients with ER, five were females, four of whom were postmenopausal. Steroid
receptors, however, had no correlation with age, tumor localization, stage of disease or IR-CEA. In cancer tissue, IR-CEA
in the cytosol fraction was higher than that found in the membrane fraction. In normal colon, however, the concentrations
of the two fractions were reversed. Immunohistochemical findings have shown a different distribution of IR-CEA in cancerous
and normal colon, and our results demonstrated similar findings by using radioimmunoassay (RIA).
Supported in part by a Grant-in-Aid for Cancer Research, No. 401004, from the Ministry of Education, Science and Culture,
Japan. 相似文献
69.
Toshihiko Asanuma Ryu Mabuchi Kasumi Masuda Hatsue Ueda-Ishibashi Satoshi Nakatani 《Journal of Echocardiography》2010,8(4):101-105
Background
Reports on ultrasound inflammation imaging with non-specific targeted microbubbles in the heart have been scarce. We investigated whether inflammation induced by myocardial ischemia–reperfusion in rats could be evaluated by ultrasound inflammation imaging with non-specific targeted microbubbles. 相似文献70.
Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis 总被引:17,自引:0,他引:17
Ohnishi S Yanagawa B Tanaka K Miyahara Y Obata H Kataoka M Kodama M Ishibashi-Ueda H Kangawa K Kitamura S Nagaya N 《Journal of molecular and cellular cardiology》2007,42(1):88-97
Acute myocarditis is a non-ischemic inflammatory disease of the myocardium for which there is currently no specific treatment. We have previously shown that mesenchymal stem cells (MSC) can ameliorate heart injury during acute ischemia and in dilated cardiomyopathy; however, the therapeutic potential in acute myocarditis is unclear. In this study, we investigated the ability of MSC to attenuate myocardial injury and dysfunction during the acute phase of experimental myocarditis. Ten-week-old male Lewis rats were injected with porcine myosin to induce myocarditis. Cultured MSC (3x10(6) cells/rat) were injected intravenously 7 days after myosin injection. At 3 weeks, myosin injection resulted in severe inflammation and significant deterioration of cardiac function. MSC transplantation attenuated increases in CD68-positive inflammatory cells and monocyte chemoattractant protein-1 (MCP-1) expression in myocardium, and improved cardiac function in this model. Furthermore, myocardial capillary density was higher in myocarditis tissue, and was further increased by MSC transplantation. In vitro, cultured adult rat cardiomyocytes were injured in response to MCP-1, whereas this effect was attenuated by MSC-derived conditioned medium, suggesting cardioprotective effects of MSC acting in a paracrine manner. MSC transplantation attenuated myocardial injury and dysfunction in a rat model of acute myocarditis, at least in part through paracrine effects of MSC. 相似文献