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排序方式: 共有475条查询结果,搜索用时 953 毫秒
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Clinical safety and performance of a MRI conditional pacing system in patients undergoing cardiac MRI 下载免费PDF全文
Chi Keong Ching MD FHRS Rabindra Nath Chakraborty MD Tarlochan Singh Kler MD Satchana Pumprueg MD Tachapong Ngarmukos MD Joseph Yat Sun Chan MD Sumit Anand PhD Rakesh Yadav MD Surapun Sitthisook MD Ka Wing Yim MPhil Rakesh K. Jaswal MD Kartikeya Bhargava MD FHRS 《Pacing and clinical electrophysiology : PACE》2017,40(12):1389-1395
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Rong Bai Xiao Yun Yang Yu'e Song Li Lin Jia Gao Lü Chi Keong Ching Jun Pu Ruth Kam Li Fern Hsu Cun Tai Zhang Wee Siong Teo Lin Wang 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2006,8(11):1002-1010
AIMS: Malignant ventricular arrhythmias can arise in a subset of congestive heart failure (CHF) patients after they undergo cardiac resynchronization therapy (CRT), thus counteracting the haemodynamic benefits typically associated with biventricular pacing. This study seeks to assess whether alteration of the ventricular transmural repolarization and conduction due to reversal of the depolarization sequence during epicardial or biventricular pacing facilitate the development of ventricular arrhythmias. METHODS AND RESULTS: ECGs and monophasic action potential (MAP) were recorded during programmed stimulation from right ventricle (RV) endocardium (RV-Endo), left ventricle (LV) epicardium (LV-Epi), or both (biventricular, Bi-V) in 15 individuals without structural heart diseases. In patients with severe CHF and CRT (n=21), ECGs were collected during RV-Endo, LV-Epi, and Bi-V pacing. MAP duration on intracardiac electrogram, the QT, JT, and T(peak)-T(end) intervals on ECGs at different pacing sites were measured and compared. In subjects with or without structural heart disease, compared with RV-Endo pacing, LV-Epi and Bi-V pacing resulted in a longer JT (341.78+/-61.97 ms with LV-Epi, 325.86+/-59.69 ms with Bi-V vs. 286.14+/-38.68 ms with RV-Endo in CHF individuals, P<0.0001) or T(peak)-T(end) interval (121.55+/-19.88 ms with LV-Epi, 117.71+/-42.63 ms with Bi-V vs. 102.28+/-12.62 ms with RV-Endo in normal-heart subjects, P<0.0001; 199.70+/-62.44 ms with LV-Epi, 184.89+/-74.08 ms with Bi-V vs. 146.41+/-31.06 ms with RV-Endo in CHF patients, P<0.0001), in addition to prolonged myocardial repolarization time and delayed endocardial activation. During follow-up, sudden death and arrhythmia storm occurred in two CHF patients after CRT. CONCLUSION: Epicardial and biventricular pacing prolong the time and increase the dispersion of myocardial repolarization and delay the transmural conduction. All of these should be considered as potential arrhythmogenic factors in CHF patients who receive CRT. 相似文献
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Activation of the CPP32 protease in apoptosis induced by 1-beta-D- arabinofuranosylcytosine and other DNA-damaging agents 总被引:2,自引:0,他引:2
The response of human myeloid leukemia cells to treatment with 1-beta- arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in this response are unknown. The present studies show that ara-C treatment of U-937 cells is associated with induction of a protease activity that cleaves the tetrapeptides Ac-DEVD- pNA and Ac-DMOD-pNA found at the cleavage sites of PARP and PKC delta, respectively. The ara-C-induced protease activity was sensitive to overexpression of the anti-apoptotic protein Bcl-xL and the baculovirus protein p35. By contrast, overexpression of the cowpox virus protein CrmA blocked apoptosis induced by engagement of the Fas receptor but not that induced by ara-C. CrmA overexpression also had no detectable effect on ara-C-induced cleavage of PKC delta. The results further show that ara-C induces activation of the CPP32 protease by a CrmA- insensitive and p35-sensitive mechanism. Similar results were obtained with cisplatinum, etoposide, and camptothecin. These findings indicate that ara-C and other DNA-damaging agents activate a CrmA-insensitive apoptotic pathway involving CPP32 and that these signals differ from those associated with apoptosis induced by the Fas receptor. 相似文献
45.
Pulmonary vein calcification by EBCT in patients with drug refractory nonvalular atrial fibrillation
James Adams Andrea Natale Claude S. Elayi Luigi Di Biase David O. Martin Salwa Beheiry Steven Hao Richard Hongo Chi Keong Ching 《Journal of interventional cardiac electrophysiology》2008,22(3):173-175
INTRODUCTION: Pulmonary veins in patients with atrial fibrillation (AF) have been shown to be highly arrhythmogenic. Calcification in these veins may play an adjunctive role in the pathogenesis of AF. METHODS AND RESULTS: A case control study was performed in patients with drug refractory nonvalvular AF whose preablation computed tomography chest scans demonstrated pulmonary vein (PV) calcification. Eight out of 48 patients with PV calcification were compared to 50 patients without AF who underwent electron beam computed tomography coronary artery calcium scores. These patients were matched for age, gender, coronary artery calcium scores, and the presence of PV calcification. The mean age of the combined group was 57 +/- 9 years and 60% were men. The mean total PV calcium score was significantly higher at 199 +/- 112 in patients with AF compared to 106 +/- 52 in controls (p = 0.018). Men had significantly higher total PV calcium score than women in both groups. CONCLUSION: Total PV calcium score was significantly higher in patients with atrial fibrillation. Increased PV calcification may play an adjunctive role in the pathogenesis in initiating and maintaining AF. 相似文献
46.
Derek Griffiths Paul Abrams Carlos A. D’Ancona Philip van Kerrebroeck Osamu Nishizawa Victor W. Nitti Foo Keong Tatt Andrea Tubaro Alan J. Wein Mo Belal 《Current Bladder Dysfunction Reports》2008,3(1):49-57
Urodynamic investigation is recommended when it influences the management of patients and is used before invasive therapies
for lower urinary tract dysfunction. Urodynamics has been shown to improve symptomatic and objective outcomes after surgical
treatment of bladder outlet obstruction (BOO) of which benign prostatic obstruction (BPO) is the principal cause. The diagnosis
of BOO is made from pressure-flow studies (PFS) of micturition using the International Continence Society nomogram, which
places patients in three categories: obstructed (BOO index [BOOI] ≥ 40); equivocal (no definite obstruction; BOOI 20–40);
and no obstruction (BOOI ≤ 20). PFS are reliable and reproducible; however, they are invasive tests, and efforts to find sensitive
and specific methods of diagnosing BPO without catheterization are under way. Promising noninvasive techniques include the
penile compression release index, the condom catheter method, and the penile cuff technique. Uroflowmetry and the ultrasound
estimation of residual urine remain useful screening tests. Due to its diagnostic and prognostic value, urodynamics is recommended
to assess lower urinary tract symptoms before surgery to relieve BOO. 相似文献
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