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991.
MR imaging of cervical carcinoma: comparison among T2-weighted,dynamic, and postcontrast T1-weighted images with histopathological correlation 总被引:4,自引:0,他引:4
K. Tsuda T. Murakami H. Kurachi H. Ogawa H. Oi A. Miyake Y. Narumi H. Nakamura 《Abdominal imaging》1997,22(1):103-107
Background: To identify the reasons for misdiagnosis of the degree of stromal invasion by uterine cervical cancer with various magnetic
resonance sequences.
Methods: T2-weighted, dynamic, and postcontrast T1-weighted images were obtained in the sagittal plane in 20 patients with uterine
cervical cancer. After evaluating these sequences for the degree of stromal invasion, histologic specimens were directly correlated
with these images.
Results: The degree of stromal invasion was correctly diagnosed in 15 of the 20 cases on T2-weighted images, in 12 on dynamic images,
and in eight on postcontrast T1-weighted images. All misdiagnoses were due to overestimation. Histologically, peritumoral
stroma showed inflammation or edema in two patients, whereas no histological abnormality was found in the other patients.
A hyperintense rim, i.e., a peritumoral enhanced ring-shaped structure, was observed on the enhanced images of five patients.
The hyperintense rim corresponded to the periphery of the tumor in three patients and to the cervical stroma in two patients.
Conclusion: T2-weighted images permitted the most accurate evaluation of stromal invasion by uterine tumors. Overdiagnosis may be due
to an abnormal intensity of the cervical stroma, which was observed more frequently on dynamic and postcontrast T1-weighted
images than on T2-weighted images.
Received: 10 November 1995/Accepted after revision: 13 March 1996 相似文献
992.
Noriaki Yokogawa Hideki Murakami Satoru Demura Satoshi Kato Katsuhito Yoshioka Hiroyuki Tsuchiya 《The spine journal》2018,18(3):381-386
Background Context
The incidence of incidental durotomy (ID) during total en bloc spondylectomy (TES) tends to be higher than that during other spinal surgeries because of the peculiarities of TES, including its highly invasive nature, epidural tumor extension, and use in patients who often have complicated medical backgrounds. However, there have been no detailed reports on ID associated with TES.Purpose
The study aimed to investigate ID during TES in detail.Study Design
This is a retrospective review of prospectively collected data.Patient Sample
The study included 105 consecutive patients with spinal tumor who underwent TES between May 2010 and February 2015 (59 men, 46 women; mean age, 54.0 years [range, 14–75 years] at the time of surgery).Outcome Measures
Outcome measures included the incidence, risk factors, anatomical location, intraoperative maneuvers, and postoperative course of ID associated with TES.Materials and Methods
Medical and operative records and imaging findings were reviewed. Univariate analysis and multivariable stepwise logistic regression models were used to identify independent risk factors for ID.Results
Incidental durotomy occurred in 18 (17.1%) of the 105 patients. The univariate and multivariate analyses demonstrated that older age (adjusted odds ratio [aOR], 6.09; 95% confidence interval [CI], 1.17–31.76; p=.03), radiotherapy (RT) history (aOR, 5.31; 95% CI, 1.46–19.49; p=.01), and revision surgery (aOR, 19.42; 95% CI, 3.46–109.14; p<.01) were independent risk factors for ID. Incidental durotomy was more likely to occur during dissection of tumor tissues in proximity to the nerve root. Although all of the ID cases were primarily sutured and covered with polyglycolic acid mesh and fibrin glue spray, eight cases required additional intervention because of intractable postoperative cerebrospinal fluid leakage. Six of these eight had a history of RT.Conclusions
Our results may help better identify high-risk patients for ID during TES, which may aid surgeons with optimal surgical decision making and in counseling patients on perioperative complications. 相似文献993.
994.
T Kondo K Murakami H Isobe N Taniguchi Y Kawakami 《Clinica chimica acta; international journal of clinical chemistry》1990,191(3):169-174
A simple and rapid enzyme-linked immunoassay for human erythrocyte carbonic anhydrase isozyme I was developed. The assay was found to be sensitive enough for the detection of nanogram amounts of the enzyme in incubation mixtures. The first incubation with anti-human carbonic anhydrase I IgG was carried out for 6 hours at room temperature. The second incubation of the enzyme was carried out in the presence of goat plasma C1q coupled with peroxidase for 1 h at room temperature. The enzymatic reaction was performed for 30 min using 2,2'-azino-di(3-ethyl-benzthiazoline sulfonate) as a substrate, and absorbance at 414 nm was recorded. Carbonic anhydrase I was assayed on the range of 1 to 200 ng/ml using this method. The levels of carbonic anhydrase I in K562 cells induced by erythropoietin and in other blood cells were determined. This enzyme-linked immunoassay has application for the study of developing erythroid cells. 相似文献
995.
Effects of Breeding Environments on Generation and Activation of Autoreactive B-1 Cells in Anti-red Blood Cell Autoantibody Transgenic Mice 总被引:4,自引:1,他引:4
Masao Murakami Kazuo Nakajima Ken-ichi Yamazaki Takehiko Muraguchi Tadao Serikawa Tasuku Honjo 《The Journal of experimental medicine》1997,185(4):791-794
In anti-red blood cell autoantibody transgenic (autoAb Tg) mice almost all B cells are deleted except for B-1 cells in the peritoneal cavity and the gut. About one-half of the auto Ab Tg mice suffer from autoimmune hemolytic anemia (AIHA) in the conventional condition. Oral administration of lipopolysaccharides activates B-1 cells and induces autoimmune symptoms in the Tg mice, suggesting that the autoimmune disease in anti-RBC autoAb Tg mice is triggered by infections. To examine the association of bacterial infections with the generation of B-1 cells and the occurrence of the autoimmune disease, we analyzed anti-RBC autoAb Tg mice bred in germ-free and specific pathogen-free conditions. In germ-free conditions, few peritoneal B-1 cells were detected, while a significant number of peritoneal B-1 cells existed in specific pathogen-free conditions. In both conditions, no mice suffered from AIHA. However, when these Tg mice were transferred to the conventional condition or injected with lipopolysaccharide, peritoneal B-1 cells expanded and some of these mice suffered from AIHA. These results clearly showed that bacterial infections are responsible for both the expansion of B-1 cells and the onset of the autoimmune disease in these Tg mice. 相似文献
996.
997.
Yoshinao Kobayashi Masayoshi Doi Hiroshi Nagata Kazunori Sasaki Toshiyuki Maruyama Kazuhisa Murakami 《Journal of infection and chemotherapy》1998,4(4):195-200
Colonization ofHelicobacter felis was observed to continue for at least 24 weeks in a BALB/c mouse stomach after oral inoculation of the bacteria. Bacteria
were observed on the surface of the gastric mucosa and in the gastric pits as is typically seen withHelicobacter pylori infection in the human stomach.H. felis-colonized mice were treated for 5 consecutive days with various chemotherapeutic regimens used againstH. pylori for humans. The status ofH. felis infection was then assessed by the urease test 2 weeks after the final treatment. The clearance rates were 100% for a triple
combination of amoxicillin (15 mg/kg), metronidazole (10 mg/kg) and bismuth subnitrate (5 mg/kg), 71% for amoxicillin alone
(15 mg/kg), 80% for metronidazole alone (15 mg/kg), and 0% for bismuth subnitrate (60 mg/kg) or omeprazole (60 mg/kg) alone.
Bacterial recurrence occurred more often in mice treated with amoxicillin alone than with the triple regimen during the 24-week
posttreatment period. These results were very similar to the efficacy of each regimen obtained in clinical trials. Thus, this
mouse model usingH. felis may be useful for evaluating drugs or regimens for the treatment of humanH. pylori infections. 相似文献
998.
Midori Hasegawa Nahoko Kawamura Masami Kasugai Sigehisa Koide Masamitsu Murase Sinsuke Asano Takako Toba Hiroko Kushimoto Kazutaka Murakami Makoto Tomita Masahiko Shikano Satoshi Sugiyama 《Therapeutic apheresis》2002,6(6):443-449
To minimize the adverse effects of high-dose administration of steroids and cyclophosphamide in patients with myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA), granulocytapheresis (GCAP) or leukocytapheresis (LCAP) was performed to reduce inflammation. Four patients with rapidly progressive glomerulonephritis (RPGN) and one patient with pulmonary hemorrhage due to MPO-ANCA-associated vasculitis were treated by cytapheresis. The prednisolone (PSL) dose was 0.28 +/- 0.15 mg/kg/day (mean +/- SD) (range 0.18-0.50 g/kg/day). In the 4 RPGN patients, the peak serum creatinine level was 3.7 +/- 1.9 mg/dl (range 1.7 to 5.6 mg/dl). GCAP was performed in 3 RPGN patients and in 1 pulmonary hemorrhage patient. LCAP was performed in 1 RPGN patient. In the 4 RPGN patients, renal function improved after combined therapy with cytapheresis and corticosteroids. In the pulmonary hemorrhage patient, evidence of pulmonary hemorrhage on chest computed tomography scanning diminished after combined therapy with cytapheresis and corticosteroids. Cytapheresis, when combined with a low-dose or intermediate-dose PSL regimen, is effective in the treatment of ANCA-associated vasculitis. 相似文献
999.
Y. Yunoki H. Takeuchi Y. Makino I. Murakami Y. Yasui K. Tanakaya K. Kawaguchi E. Konaga 《Abdominal imaging》1999,24(4):398-400
We report a solitary intraperitoneal recurrence in a long-term survivor after rupture of hepatocellular carcinoma. Ultrasonography demonstrated the finding of a lobulated mass with a "mosaic" appearance. The patient underwent resection of this implant and is currently disease free. We emphasize the importance of periodic surveillance of disseminated metastases of this condition. 相似文献
1000.
Hisada Y Sugaya T Yamanouchi M Uchida H Fujimura H Sakurai H Fukamizu A Murakami K 《The Journal of clinical investigation》1999,103(5):627-635
Several lines of evidence show the importance of angiotensin II (AII) in renal injuries, especially when hemodynamic abnormalities are involved. To elucidate the role of AII in immune-mediated renal injury, we studied anti-glomerular basement membrane (GBM) nephritis in AII type 1a receptor (AT1a)-deficient homozygous (AT1a-/-) and wild-type (AT1a+/+) mice. A transient activation of the renin-angiotensin system (RAS) was observed in both groups of mice at around day 1. A renal expression of monocyte chemoattractant protein-1 (MCP-1) was transiently induced at six hours in both groups, which was then downregulated at day 1. In the AT1a+/+ mice, after RAS activation, the glomerular expression of MCP-1 was exacerbated at days 7 and 14. Thereafter, severe proteinuria developed, and the renal expressions of transforming growth factor-beta1 (TGF-beta1) and collagen type I increased, resulting in severe glomerulosclerosis and interstitial fibrosis. In contrast, glomerular expression of MCP-1, proteinuria, and tissue damage were markedly ameliorated in the AT1a-/- mice. Because this amelioration is likely due to the lack of AT1a, we can conclude that AII action, mediated by AT1a, plays a pathogenic role in anti-GBM nephritis, in which AII may contribute to the exacerbation of glomerular MCP-1 expression. These results suggest the involvement of AII in immune-mediated renal injuries. 相似文献