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101.
Igarashi H Ito T Kawabe K Hisano T Arita Y Kaku T Takayanagi R 《World journal of gastroenterology : WJG》2008,14(34):5311-5315
AIM:To evaluate the chemoradiotherapy for locally advanced pancreatic cancer utilizing low dose gemcitabine as a radiation sensitizer administered twice weekly. METHODS: We performed a retrospective analysis of chemoradiotherapy utilizing gemcitabine administered twice weekly at a dose of 40 mg/m2. After that, maintenance systemic chemotherapy with gemcitabine, at a dose of 1000 mg/m2, was administered weekly for 3 wk with 1-wk rest until disease progression or unacceptable toxicity developed. RESULTS: Eighteen patients with locally advanced unresectable pancreatic cancer were enrolled. Three of those patients could not continue with the therapy; one patient had interstitial pneumonia during radiation therapy and two other patients showed liver metastasis or peritoneal metastasis during an early stage of the therapy. The median survival was 15.0 mo and the overall 1-year survival rate was 60%, while the median progression-free survival was 8.0 mo. The subgroup which showed the reduction of tumor development, more than 50% showed a tendency for a better prognosis; however, other parameters including age, gender and performance status did not correlate with survival. The median survival of the groups that died of liver metastasis and peritoneal metastasis were 13.0 mo and 27.7 mo, respectively.CONCLUSION: Chemoradiotherapy with low-dose gemcitabine administered twice weekly could be effective to patients with locally advanced pancreatic cancer; however, patients developing liver metastases had a worse prognosis. Another chemoradiotherapy strategy might be needed for those patients, such as administrating one or two cycles of chemotherapy initially, followed by chemoradiotherapy for the cases with no distant metastases. 相似文献
102.
Hiroto Miwa Hisae Matsushima Takeshi Terai Hiroshi Tanaka Masato Kawabe Akihiro Namihisa Sumio Watanabe Nobuhiro Sato 《Journal of gastroenterology》1998,33(4):556-561
We report a patient—a 42-year-old man—who had suffered from recurrent duodenal ulcer for about 20 years. Successful curative
therapy for Helicobacter pylori infection was performed for 2 weeks with new triple omeprazole, anoxicillin, clarithromycin (OAC) treatment in October 1995,
and cure of the infection was repeatedly confirmed by histology, culture, and the 13C urea breath test. One month after the curative therapy, recurrence of a small duodenal ulcer was observed and in February
another duodenal ulcer and reflux esophagitis occurred, with severe symptoms, despite the continuous administration of ranitidine.
None of the examinations to reconfirm cure of the infection revealed the presence of H. pylori. As the patient experienced continual psychological stress and smoked more frequently during the recurrent episode and had
not used nonsteroidal anti-inflammatory drugs, stress and smoking appeared to play important roles in the relapse of duodenal
ulcer in this patient after cure of H. pylori infection.
(Received Aug. 18, 1997; accepted Jan. 23, 1998) 相似文献
103.
Ichino N Osakabe K Nishikawa T Sugiyama H Kato M Kitahara S Hashimoto S Kawabe N Harata M Nitta Y Murao M Nakano T Arima Y Shimazaki H Suzuki K Yoshioka K 《World journal of gastroenterology : WJG》2010,16(38):4809-4816
AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of... 相似文献
104.
105.
106.
Suguru Mizuno Kenji Hirano Minoru Tada Keisuke Yamamoto Yoko Yashima Hiroshi Yagioka Kazumichi Kawakubo Yukiko Ito Hirofumi Kogure Takashi Sasaki Toshihiko Arizumi Osamu Togawa Saburo Matsubara Yousuke Nakai Naoki Sasahira Takeshi Tsujino Hiroyuki Isayama Takao Kawabe Masao Omata Kazuhiko Koike 《Journal of gastroenterology》2010,45(7):758-762
Background
It is known that bezafibrate decreases serum alkaline phosphatase (ALP) in patients with hyperlipidemia, and the efficacy of this drug for the treatment of primary biliary cirrhosis has been confirmed. However, there has been little evidence of its efficacy for the treatment of primary sclerosing cholangitis (PSC).Methods
Bezafibrate (400 mg/day) was orally administered to 7 consecutive patients with PSC, and we analyzed their clinical features and the drug efficacy in terms of the effect on hepatobiliary enzymes, including ALP, gamma-glutamyl transpeptidase (γ-GTP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) after 6 months. The latest hepatobiliary enzyme levels were also evaluated.Results
In 3 patients (effective group), the levels of all hepatobiliary enzymes had decreased after 6 months. Mean ALP had decreased to approximately 40% of the baseline in this group. The efficacy of bezafibrate was observed for a long period (range, 8–27 months) in these 3 patients. There seemed to be no definite association between the efficacy of bezafibrate and the clinical features in the short term.Conclusions
This study showed that bezafibrate could lower the levels of hepatobiliary enzymes in about half of a cohort of patients with PSC. 相似文献107.
Hiroyuki Isayama Keisuke Yamamoto Suguru Mizuno Yoko Yashima Osamu Togawa Hirofumi Kogure Takashi Sasaki Naoki Sasahira Yousuke Nakai Kenji Hirano Takeshi Tsujino Minoru Tada Takao Kawabe Masao Omata 《Journal of Hepato-Biliary-Pancreatic Surgery》2009,16(3):270-273
Endoscopists seek to conduct more aggressive surgical procedures that surpass the limitations of existing endoscopic procedures.
Endoscopic pancreatic necrosectomy and natural orifice transluminal endoscopic surgery (NOTES) are typical examples of this
new trend; both are performed through the gastrointestinal wall without a skin incision. Endoscopic necrosectomy is effective
for managing organized pancreatic necrosis and abscesses. The necrotic tissues are removed endoscopically by directly entering
the cavity of the organized pancreatic necrosis. NOTES is a possible advance over surgical intervention, as it is a less invasive,
more cosmetic, and effective procedure. There are various approaches, including the esophagus, stomach, colon, and vagina;
Various procedures are possible using NOTES, such as cholecystectomy, appendectomy, full-thickness stomach resection, splenectomy,
gastrointestinal (GI) anastomosis, and peritoneoscopy. The requirements for NOTES include high proficiency in endoscopic techniques,
including knowledge of various devices, anatomy, and surgical procedures. Since most GI endoscopists have no surgical background,
to increase the usage of NOTES, GI endoscopists should form and lead teams that include various specialists. We believe that
endoscopic necrosectomy and NOTES represent a major shift in the treatment paradigm because physicians can treat beyond the
gastrointestinal wall and endoscopic procedures will replace surgical treatment. 相似文献
108.
Hirabayashi Y Okumura A Kondo T Magota M Kawabe S Kando N Yamaguchi H Natsume J Negoro T Watanabe K 《Brain & development》2009,31(6):414-418
Purpose: To assess the efficacy of diazepam suppositories at preventing febrile seizure recurrence during a single febrile illness to determine how to treat children with a febrile seizure on presentation at the hospital. Methods: We studied 203 children with febrile seizures from December 2004 through March 2006. On admission between December 2004 and May 2005, a diazepam suppository was administered to the patients. Patients seen between June 2005 and March 2006 were not treated with antiepileptic drugs on admission. Results: We saw a significant difference in the rate of recurrence of febrile seizures between children treated with diazepam and those who were not. Recurrences were observed in 2 (2.1%) of 95 children treated with diazepam and in 16 (14.8%) of 108 untreated children. For the 108 untreated patients, the median age was 22.8 months in those with recurrences and 30.6 months in those without, confirming that a younger age was related to a recurrence. Conclusions: A diazepam suppository after a febrile seizure will reduce the incidence of recurrent febrile seizures during the same febrile illness. However, a diazepam suppository after a febrile seizure should be used after carefully considering the benefits and potential adverse effects. 相似文献
109.
Miyoko Matsushima Kenzo Takagi Miyuki Ogawa Etsuko Hirose Yui Ota Fumie Abe Kenji Baba Takaaki Hasegawa Yoshinori Hasegawa Tsutomu Kawabe 《Inflammation research》2009,58(10):705-715
Objective and design
We investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of quercetin against degranulation of rat basophilic leukemia (RBL-2H3) cells, rat peritoneal mast cells, and mouse bone marrow-derived mast cells. 相似文献110.
Kawabe H Saito I Saruta T 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2007,29(1):43-49
Home blood pressure (HBP) is usually measured in the morning and evening, but the evening HBP tends to be influenced by an individual's behavior pattern, such as bathing and drinking, which are often seen in the Japanese. In this study, in order to elucidate the influence of nighttime drinking on the evening and next morning HBP and heart rate (HR), HBP measurement was performed in Japanese normotensives under conditions in which the influence of bathing was minimized. Among 700 registered volunteers, 245 normotensives (189 male, 56 female, mean age; 35.8 +/- 0.5 years old) whose data consisted of a combination of drinking and non-drinking on workdays were selected. A semi-automatic device was lent to all participants, and they were asked to perform triplicate morning and evening measurements on seven consecutive days between October 16, 2002, and November 13, 2002. The differences in evening HBP and HR between the drinking and non-drinking days were calculated, as were the differences in the next morning HBP and HR. Only data of evening HBP measured at least 30 min after bathing were accepted. Evening SBP and DBP on drinking days were significantly lower (2.5 +/- 0.5 mmHg, 3.1 +/- 0.5 mmHg) than those on non-drinking days. On the other hand, evening HR on drinking days was significantly higher (7.7 +/- 0.8 b.p.m.) than that on non-drinking days. Although there was no difference in morning SBP after days with and without drinking, morning DBP the day after drinking was slightly (0.8 +/- 0.3 mmHg) but significantly lower than that the day after non-drinking. Morning HR the day after drinking was significantly higher (2.4 +/- 0.4 b.p.m.) than that after non-drinking. Because nighttime drinking influenced the evening HBP even in normotensives, it was suggested that morning HBP could give more stable values than evening HBP in Japanese people. 相似文献