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排序方式: 共有2600条查询结果,搜索用时 12 毫秒
101.
Shiga T Hosaka F Wakaumi M Matsuda N Tanizaki K Kajimoto K Shoda M Hagiwara N Kasanuki H 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2003,17(4):325-333
Brain natriuretic peptide (BNP) is a powerful neurohormonal marker of left ventricular function and prognosis. Amiodarone either has no effect or improves the haemodynamics in patients with left ventricular dysfunction, but its effect on BNP is unknown. This study evaluated the effect of amiodarone on plasma BNP level in patients with heart failure and ventricular tachyarrhythmia.Plasma BNP level was studied in 46 patients with heart failure ventricular tachyarrhythmia, before (baseline) and at week 2 and months 1, 3 and 6 of amiodarone treatment. In addition, 21 patients with heart failure and ventricular tachyarrhythmia, who received an implantable cardioverter defibrillator, but not amiodarone, were studied on the same schedule. All patients had previously received potent vasodilator and beta-blocker therapy. Echocardiography and Holter monitoring were also performed.Amiodarone significantly decreased plasma BNP levels at week 2 to month 6 during therapy. Heart rates and frequencies of premature ventricular complexes were markedly reduced by amiodarone. Echocardiographic findings did not show a change in left ventricular end-diastolic dimensions, despite a slight increase in fraction shortening at month 6 during amiodarone therapy. The above parameters showed no change in patients without amiodarone. The effect of heart rate, premature ventricular complexes, fraction shortening, serum creatinine or thyroid stimulating hormone level was not significantly associated with decrease in BNP level during amiodarone therapy by a multivariate analysis. Among amiodarone-treated patients, mortality was higher in 24 with BNP levels 100 pg/ml at month 6 than in 22 with BNP levels <100 pg/ml during a mean follow-up period of 31 months.Amiodarone appears to have a decreasing effect on plasma BNP level, as well as an antiarrhythmic effect, in patients with heart failure and ventricular tachyarrhythmia. 相似文献
102.
Katsuya Yanagisawa Kenichi Nishie Hidekazu Takahashi Kenji Sano Kazuyoshi Takei Hiroshi Yamamoto Tomonobu Koizumi Masayuki Hanaoka 《Internal medicine (Tokyo, Japan)》2022,61(6):883
A 71-year-old man presented with cough and bloody sputum. Computed tomography showed a mass in the lower lobe of the left lung. Histological findings in biopsy tissue revealed a malignant peripheral nerve sheath tumor (MPNST). The patient was diagnosed with primary lung MPNST based on a systemic examination. Although initial chemotherapy treatment with doxorubicin failed to control the disease, radiotherapy considerably shrank the tumor. Primary lung MPNSTs are rare, and there is no established treatment for inoperable cases. This case suggests that radiotherapy is a treatment option for primary lung MPNST. 相似文献
103.
Disseminated toxoplasmosis after hematopoietic stem cell transplantation showing unusual magnetic resonance images
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Takahiro Tateno Masahiro Onozawa Junichi Hashiguchi Takashi Ishio Sayaka Yuzawa Satomi Matsuoka Mizuha Kosugi‐Kanaya Kohei Okada Souichi Shiratori Hideki Goto Taichi Kimura Junichi Sugita Masao Nakagawa Daigo Hashimoto Kaoru Kahata Katsuya Fujimoto Tomoyuki Endo Takeshi Kondo Shinya Tanaka Satoshi Hashino Takanori Teshima 《Transplant infectious disease》2017,19(4)
We herein report a patient who had disseminated toxoplasmosis after hematopoietic stem cell transplantation showing atypical clinical presentation and neuroimaging. Parkinsonism symptoms such as muscle rigidity, bradykinesia, tremor, and postural instability were initial manifestations. Magnetic resonance imaging showed diffuse symmetrical lesions of bilateral basal ganglia lacking ringed enhancement. Post‐mortem analysis revealed multiple tachyzoites of Toxoplasma gondii in the basal ganglia, mid brain, cerebellum, and cardiac muscle. 相似文献
104.
Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization 总被引:8,自引:0,他引:8
Okano H Shiraki K Yamanaka Y Inoue H Kawakita T Saitou Y Yamaguchi Y Enokimura N Ito K Yamamoto N Sugimoto K Murata K Nakano T 《World journal of gastroenterology : WJG》2005,11(30):4650-4654
AIM: To detect the expression of a proliferation-related ligand on human hepatocellular carcinoma (HCC) cell lines (SK-Hep1, HLE and HepG2) and in culture medium. METHODS: APRIL expression was analyzed by Western blotting in HCC cell lines. Effects of APRIL to cell count and angiogenesis were analyzed, too. RESULTS: Recombinant human APRIL (rhAPRIL) increased cell viability of HepG2 cells and, in HUVEC, rhAPRIL provided slight tolerance to cell death from serum starvation. Soluble APRIL (sAPRIL) from HLE cells increased after serum starvation, but did not change in SK-Hepl or HepG2 cells. These cells showed down-regulation of VEGF after incubation with anti-APRIL antibody. Furthermore, culture medium from the HCC cells treated with anti-APRIL antibody treatment inhibited tube formation of HUVECs. CONCLUSION: Functional expression of APRIL might contribute to neovascularization via an upregulation of VEGF in HCC. 相似文献
105.
Hirano K 《Arteriosclerosis, thrombosis, and vascular biology》2007,27(1):27-36
Proteinase-activated receptors (PARs) belong to a family of G protein-coupled receptors, thus mediating the cellular effects of proteinases. In the vascular system, thrombin and other proteinases in the coagulation-fibrinolysis system are considered to be the physiologically relevant agonists, whereas PARs are among the most important mechanisms mediating the interaction between the coagulation-fibrinolysis system and the vascular wall. Under physiological conditions, PARs are mainly expressed in endothelial cells, and participate in the regulation of vascular tone, mostly by inducing endothelium-dependent relaxation. PARs in endothelial cells are also suggested to contribute to a proinflammatory phenotypic conversion and an increase in the permeability of vascular lesions. In smooth muscle cells, PARs mediate contraction, migration, proliferation, hypertrophy, and production of the extracellular matrix, thereby contributing to the development of vascular lesions and the pathophysiology of such vascular diseases as atherosclerosis. However, the expression of PARs in the smooth muscle of normal arteries is limited. The upregulation of PARs in the smooth muscle is thus considered to be a key step for PARs to participate in the pathogenesis of vascular lesions. Elucidating the molecular mechanism regulating the PARs expression is therefore important to develop new strategies for the prevention and treatment of vascular diseases. 相似文献
106.
Sakuraoka Y Sawada T Okada T Shiraki T Miura Y Hiraishi K Ohsawa T Adachi M Takino J Takeuchi M Kubota K 《World journal of gastroenterology : WJG》2010,16(42):5334-5341
AIM:To investigate the proliferative effect of advanced glycation end-products(AGEs) and the role of their cellular receptor(RAGE) on hepatocellular carcinoma(HCC) cells,and the inhibitory effects of MK615,an extract from Japanese apricot,against AGEs were also evaluated.METHODS:Two HCC cell lines,HuH7 and HepG2,were used.Expression of RAGE was investigated by poly-merase chain reaction,Western blotting,and flow cytemetry(FACS).The effect of MK615 on RAGE expression was also evaluated by FACS.The proliferat... 相似文献
107.
Yukiko Kanno Masashi Watanabe Taichi Kimura Katsuya Nonomura Shinya Tanaka Shigetsugu Hatakeyama 《Acta histochemica》2014
Tripartite motif protein 29 (TRIM29) is one of the TRIM family proteins, some of which function as E3 ubiquitin ligases. In this study, we investigated the usefulness of TRIM29 for diagnosis of prostate cancer. Prostate tissues including carcinoma and non-carcinoma tissues obtained by needle biopsy and radical prostatectomy were used. Immunohistochemistry was performed according to standard procedures using an antibody against TRIM29. Immunohistochemical staining with an antibody against 34βE12, which recognizes cytokeratins 1, 5, 10 and 14, was performed as a control. Basal cells of normal prostatic glands were stained with anti-TRIM29 antibody in all cases, whereas prostate cancer tissues had no or little staining with anti-TRIM29 antibody. TRIM29 is selectively expressed in basal cells of the normal prostate gland, and immunohistochemical staining with anti-TRIM29 antibody showed the same expression pattern as that with 34βE12 in prostate cancer and its benign mimics. Our data indicate that TRIM29 may be useful for distinguishing prostate cancers from benign tissues. 相似文献
108.
The familial occurrence of epidermoid cysts of the spleen is rare, with only six cases having ever been reported, to our knowledge.
We recently diagnosed epidermoid cysts of the spleen in a mother and son. First, a 15-year-old boy was admitted to our hospital
for management of blunt abdominal trauma. Computed tomography (CT) showed a ruptured large splenic cyst with an intraabdominal
hematoma. We performed a splenectomy, and histopathological examination confirmed the existence of an epidermoid cyst of the
spleen. About 2 years and 6 months later, the family physician found that the patient's 41-year-old mother had a large splenic
cyst, and she was referred to our hospital for further investigation. CT showed a 10 × 8 cm cyst occupying most of the spleen.
The patient underwent splenectomy, and a pathological diagnosis of an epidermoid cyst of the spleen was confirmed. Although
the etiology of epidermoid cysts of the spleen is unclear, this familial occurrence may support the hypothesis of congenital
malformation as a result of genetic change. 相似文献
109.
Kawahara H Hirai K Watanabe K Kashiwagi H Yamazaki Y Yanaga K 《International surgery》2007,92(1):34-36
Conventional functional end-to-end anastomosis (FEEA) is not indicated for left hemicolectomy, sigmoidectomy, and anterior resection. However, our original anastomosis with stapling devices (SFEEA) can be performed at any site in the intestine. We report our novel surgical technique compared with the double stapling technique (DST). Between January 2001 and August 2003, anterior resection with stapling devices was performed in 74 patients (DST, 54; SFEEA, 20). The SEEEA group was greater than the DST group in operation time and significant intraoperative blood loss. In the DST group, two postoperative complications (3.7%) occurred (leakage and stenosis). On the other hand, no complications were noted in the SFEEA group. Our novel technique for colorectal anastomosis, SFEEA, allows safe, wide, physiological, and clean anastomosis compared with FEEA. 相似文献
110.
Katsuya Tamai Kenji Kawate Ikuo Kawahara Yoshinori Takakura Kazuhiko Sakaki 《Journal of orthopaedic science》2009,14(2):204-209
Background For orthopedic implants, infection is a serious problem. Therefore, we considered an implant with antimicrobial ability can
prevent infection. We tried to coat a titanium alloy surface with Novaron, a commercially available inorganic antimicrobial.
The purpose of this study was to analyze the differences among the surfaces of materials coated using different processing
pressures of the working gas and analysis of the antimicrobial activity.
Methods One of the inorganic antimicrobials Novaron (grade VZ 600) was applied to titanium alloy (Ti6Al4V) plates. This antimicrobial
has limited heat resistance, so we used cold spray technology to coat the titanium alloy with it. The principle of cold spray
technology is spraying a powder in a high-velocity gas jet, accelerated by adiabatic expansion, against a substrate. Scanning
electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS) were used to analyze the differences among the surfaces
of materials coated using different processing pressures of the working gas. The Japanese Industrial Standard (JIS) method
(JIS Z2801: 2000) was used to analyze the antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Antimicrobial activity was analyzed only for the sample coated at 3.0 MPa.
Results The SEM and EDS results indicated that when the pressure of the working gas was increased, the antimicrobial coated the titanium
adequately. This material showed good effects against S. aureus and P. aeruginosa and some effect for K. pneumoniae.
Conclusions Antimicrobial implants represent a preventive method against infection. There is a possibility of using them not only for
clean operations but also for operations with suspected bacterial contamination, such as fixation of slight compound fractures. 相似文献