全文获取类型
收费全文 | 2652篇 |
免费 | 240篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 140篇 |
妇产科学 | 63篇 |
基础医学 | 356篇 |
口腔科学 | 11篇 |
临床医学 | 363篇 |
内科学 | 425篇 |
皮肤病学 | 41篇 |
神经病学 | 284篇 |
特种医学 | 39篇 |
外科学 | 244篇 |
综合类 | 37篇 |
一般理论 | 7篇 |
预防医学 | 449篇 |
眼科学 | 93篇 |
药学 | 118篇 |
中国医学 | 2篇 |
肿瘤学 | 184篇 |
出版年
2024年 | 3篇 |
2023年 | 33篇 |
2022年 | 58篇 |
2021年 | 113篇 |
2020年 | 75篇 |
2019年 | 106篇 |
2018年 | 115篇 |
2017年 | 98篇 |
2016年 | 104篇 |
2015年 | 92篇 |
2014年 | 138篇 |
2013年 | 168篇 |
2012年 | 255篇 |
2011年 | 275篇 |
2010年 | 120篇 |
2009年 | 96篇 |
2008年 | 166篇 |
2007年 | 158篇 |
2006年 | 136篇 |
2005年 | 132篇 |
2004年 | 131篇 |
2003年 | 101篇 |
2002年 | 102篇 |
2001年 | 12篇 |
2000年 | 7篇 |
1999年 | 12篇 |
1998年 | 17篇 |
1997年 | 15篇 |
1996年 | 13篇 |
1995年 | 6篇 |
1994年 | 10篇 |
1993年 | 7篇 |
1992年 | 1篇 |
1991年 | 5篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1974年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
1964年 | 2篇 |
排序方式: 共有2893条查询结果,搜索用时 15 毫秒
91.
Chris Hoi Houng Chan Masataka Inoue Katrina K. Ki Tomotaka Murashige John F. Fraser Michael J. Simmonds Geoff D. Tansley Nobuo Watanabe 《Artificial organs》2020,44(12):1286-1295
Nonsurgical bleeding is the most frequent complication of left ventricular assist device (LVAD) support. Supraphysiologic shear rates generated in LVAD causes impaired platelet aggregation, which increases the risk of bleeding. The effect of shear rate on the formation size of platelet aggregates has never been reported experimentally, although platelet aggregation size can be considered to be directly relevant to bleeding complications. Therefore, this study investigated the impact of shear rate and exposure time on the formation size of platelet aggregates, which is vital in predicting bleeding in patients with an LVAD. Human platelet-poor plasma (containing von Willebrand factor, vWF) and fluorochrome-labeled platelets were subjected to a range of shear rates (0-10 000 s−1) for 0, 5, 10, and 15 minutes using a custom-built blood-shearing device. Formed sizes of platelet aggregates under a range of shear-controlled environment were visualized and measured using microscopy. The loss of high molecular weight (HMW) vWF multimers was quantified using gel electrophoresis and immunoblotting. An inhibition study was also performed to investigate the reduction in platelet aggregation size and HMW vWF multimers caused by either mechanical shear or enzymatic (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13—ADAMTS13, the von Willebrand factor protease) mechanism under low and high shear conditions (360 and 10 000 s−1). We found that the average size of platelet aggregates formed under physiological shear rates of 360-3000 s−1 (200-300 μm2) was significantly larger compared to those sheared at >6000 s−1 (50-100 μm2). Furthermore, HMW vWF multimers were reduced with increased shear rates. The inhibition study revealed that the reduction in platelet aggregation size and HWM vWF multimers were mainly associated with ADAMTS13. In conclusion, the threshold of shear rate must not exceed >6000 s−1 in order to maintain the optimal size of platelet aggregates to “plug off” the injury site and stop bleeding. 相似文献
92.
Paulina Kurleto Agnieszka Skorupska-Król Elżbieta Broniatowska Katrina A. Bramstedt 《Clinical transplantation》2020,34(10):e14034
Non-directed living donors are individuals who donate a kidney to a recipient with whom they have neither a genetic nor emotional relationship. Israel legalized this type of donation in 2008. After this law was implemented, living donations significantly expanded. The aim of this article was to determine the motivations, characteristics, and perioperative experiences of non-directed living donors in Israel. Three online questionnaires (own questionnaire, Rosenberg Self-Esteem Scale (RSES), Rushton Self-Report Altruism Scale) were distributed to 180 Jewish kidney donors with the help of Matnat Chaim organization. One hundred and fifteen responses were received (69.3% response rate). The motivation for most donors (60%) was a strong willingness to help and a desire to do good. The majority of donors (78.3%) reported their health status as unchanged after donation; however, 16.5% experienced clinical problems (eg, wound infection, more pain than expected), and 5.2% experienced psychological complications. About 18% reported their health to improve after donation. Most (80%) inspired someone else to also become a kidney donor. This study breaks the myth that Jews do not support organ donation. In fact, their high level of altruism and their positive experience with donation has propelled the practice of non-directed donation in Israel. 相似文献
93.
94.
95.
Nila Ilhamto Katrina Anciado Heather H. Keller 《Journal of nutrition in gerontology and geriatrics》2014,33(3):210-228
Texture modification of foods to a pureed consistency is a common management approach for older adults with dysphagia. Long-term care (LTC) facilities commonly produce some pureed food in-house. This study investigated challenges and preferred practices associated with the production of pureed food in LTC facilities. Nutrition Managers (n = 27) and cooks (n = 26) from 25 Ontario LTC facilities were recruited for one-on-one, semistructured interviews. Interviews were digitally recorded, transcribed, and analyzed using inductive thematic analysis. Four themes arose from the data to exemplify challenges in production, including (a) difficulty in using standardized recipes, (b) varied interpretation of governmental guidelines, (c) lack of consistency in terminology and texture, and (d) wanting to improve the visual appeal. These challenges were reported to reduce the quality of in-house produced pureed food. Preferred practices to overcome these challenges were also provided by participants, such as involving cooks in pureed recipe improvements and tailoring to the specific needs of residents. Incorporation of these practices into pureed food production may help to shape and improve future practice and pureed food products. 相似文献
96.
Clare Wohlgemuth Katrina Penman Monica Desai Kay Nolan Nichole Taske Paul Chrisp 《Journal of evaluation in clinical practice》2019,25(6):1027-1029
NICE's guideline on shared decision making, currently under development, endeavours to support shared decision making as part of routine health care practice. In this article, we summarize our learning to date, gained through the scoping of the guideline, on the key challenges that need to be addressed in the guideline. The production of a scope is the first stage in the development of a NICE guideline, setting the parameters for what will be considered in the guideline. The process for scoping the shared decision making guideline involved discussion with early recruited committee members and engagement with registered stakeholders, through both a workshop and formal consultation. Important, and sometimes divergent, viewpoints about shared decision making were revealed through this process. The key challenges centred on the issues of a need for a common definition of shared decision making, measurability, opportunities, barriers to implementation, and feasibility. Recognizing these challenges aided the refinement of the scope in terms of what the guideline will cover, draft questions and main outcomes for consideration. 相似文献
97.
Podsypanina K Politi K Beverly LJ Varmus HE 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(13):5242-5247
Most, if not all, cancers are composed of cells in which more than one gene has a cancer-promoting mutation. Although recent evidence has shown the benefits of therapies targeting a single mutant protein, little attention has been given to situations in which experimental tumors are induced by multiple cooperating oncogenes. Using combinations of doxycycline-inducible and constitutive Myc and mutant Kras transgenes expressed in mouse mammary glands, we show that tumors induced by the cooperative actions of two oncogenes remain dependent on the activity of a single oncogene. Deinduction of either oncogene individually, or both oncogenes simultaneously, led to partial or complete tumor regression. Prolonged remission followed deinduction of Kras(G12D) in the context of continued Myc expression, deinduction of a MYC transgene with continued expression of mutant Kras produced modest effects on life extension, whereas simultaneous deinduction of both MYC and Kras(G12D) transgenes further improved survival. Disease relapse after deinduction of both oncogenes was associated with reactivation of both oncogenic transgenes in all recurrent tumors, often in conjunction with secondary somatic mutations in the tetracycline transactivator transgene, MMTV-rtTA, rendering gene expression doxycycline-independent. These results demonstrate that tumor viability is maintained by each gene in a combination of oncogenes and that targeted approaches will also benefit from combination therapies. 相似文献
98.
99.
Katrina McFerran Felicity Baker George C. Patton Susan M. Sawyer 《European eating disorders review》2006,14(6):397-403
Song‐writing plays a central role in music therapy with adolescents. A retrospective lyrical analysis of songs written by adolescents with anorexia nervosa was undertaken in order to identify common themes solicited through song‐writing interventions. Fifteen participants contributed 17 songs, from which 368 lyrical units were identified. A modified content analysis approach was used with each lyrical unit being categorised to one of six themes determined from the literature and clinical experience. The theme of ‘identity’ was used most frequently (28%), with the sub‐theme of ‘exploring new behaviours, positive self‐talk’ being addressed most often (12.5% of total). The dominance of the developmentally important theme of ‘identity’ may reflect the relationship between adolescents, music and identity or may be related to the way in which anorexia nervosa has been theorised to assist the adolescent in managing challenges to the emerging sense of self. Copyright © 2006 John Wiley & Sons, Ltd and Eating Disorders Association. 相似文献
100.