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排序方式: 共有119条查询结果,搜索用时 8 毫秒
51.
Somapacitan,a once‐weekly reversible albumin‐binding GH derivative,in children with GH deficiency: A randomized dose‐escalation trial 下载免费PDF全文
52.
To suppress the activity of glomerulonephritis, lupus and primary chronic mixed one, 13 children received plasmapheresis synchronously with pulse therapy with cyclophosphamide or prednisolone. Plasmapheresis was carried out daily for 3 days. Six hours after the last session and on days 4 and 5 of the treatment pulse therapy was provided, followed by conventional intake of prednisolone per os in combination with azathioprine or cyclophosphamide. Beneficial therapeutic results were obtained in 10 patients within 3 to 6 weeks. The effect turned out insufficient in a patient with associated systemic lupus erythematosus, and rapid-progressing nephritis and in a child with primary chronic glomerulonephritis of the mesangiocapillary type with fibroplastic transformation and persistent nephrotic syndrome. No therapeutic effect was attained in a patient with focal segmental glomerulosclerosis running its course with long persistent nephrotic syndrome. 相似文献
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55.
细胞色素P450 2C19单碱基突变位点CYP2C19m1的分析 总被引:1,自引:0,他引:1
目的:CYP2C19ml是引起CYP2C19酶活性缺陷的主要等位基因,有83%左右的慢代谢者含有CYP2C19ml等位基因,本文试图建立一步PCR测定CYP2C19ml等位基因的方法。方法:根据等位基因特异扩增(ASA)原理设计两对分别特异扩增野生型等位基因和突变型等位基因的引物,建立了一步PCR测定CYP2C19ml等位基因的方法。结果:对39位随机受试者进行了基因分型研究,发现3位CYP2C19ml纯合子、18位CYP2C19ml杂合子,其余18位为野生型纯合子。结论:说明效法能够用于测定CYP2C19ml等住基因,并且证明该法具有简便、快速和污染少的优点。 相似文献
56.
Hemosorption was employed in multi-modality treatment of 12 children aged 10-15 years with lupus nephritis. Of these, 5 patients suffered from nephritis associated with the nephrotic syndrome (NS), 4 patients had active pronounced nephritis without the NS, and 3 patients presented with latent nephritis. One case was characterized by transitory renal failure in the acute phase while 3 cases by chronic renal failure. Hemosorption produced a beneficial effect on the renal process and on electrolyte balance. The long-term observation over the patients evidences a short-term effect of hemosorption. After the attainment of that effect the further disease course depended on the adequacy of the conservative therapy administered to the patients with lupus nephritis. 相似文献
57.
Early osteonecrosis of the femoral head: detection in high-risk patients with MR imaging 总被引:4,自引:0,他引:4
Genez BM; Wilson MR; Houk RW; Weiland FL; Unger HR Jr; Shields NN; Rugh KS 《Radiology》1988,168(2):521-524
To determine whether magnetic resonance (MR) imaging can demonstrate the early stages of osteonecrosis that are not detectable radiographically, the authors compared radiologic findings with histologic results in seven patients at high risk for osteonecrosis of the femoral head. Radiography and MR imaging were performed, and proximal femoral intramedullary pressures were measured in all patients, even if results from imaging studies were normal. If the pressures were elevated, core decompression with biopsy was performed. Seven patients had elevated pressures in 11 hips. Of 11 hips from which biopsy specimens were taken, all had histologic evidence of osteonecrosis. However, in only five were the MR imaging findings consistent with osteonecrosis. In the remaining six hips with osteonecrosis, MR imaging findings were normal. Sensitivity of MR imaging in detection of osteonecrosis was 46%. The authors conclude that normal MR imaging results in high-risk patients do not rule out the presence of osteonecrosis. 相似文献
58.
The human autosomal gene DAZLA: testis specificity and a candidate for male infertility 总被引:5,自引:1,他引:5
The DAZ (Deleted in AZoospermia) and DAZLA (DAZ-like autosomal) genes may
be determinants of male infertility. The DAZ gene on the long arm of the
human Y chromosome is a strong candidate for the 'azoospermia factor'
(AZF). Its role in spermatogenesis is supported by its exclusive expression
in testis, its deletion in a high percentage of males with azoospermia or
severe oligospermia, and its homology with a Drosophila male infertility
gene boule. No DAZ homologous sequences have been found on the mouse Y
chromosome. Instead, a Dazla gene was isolated from mouse chromosome 17 and
has been considered to be a murine homologue of DAZ. However, the homology
between human DAZ and mouse Dazla is not strong, and Dazla contains only
one of the seven DAZ repeats found in DAZ. We report the isolation of the
human DAZLA gene by screening a human testis cDNA library with a DAZ cDNA
clone. DAZLA encodes only one DAZ repeat and shares high homology with the
mouse Dazla, indicating that these two genes are homologues. Using a panel
of rodent-human somatic cell lines and fluorescence in situ hybridization,
the DAZLA gene was mapped to 3p24, a region not known to share homology
with mouse chromosome 17. The DAZLA gene may be involved in some familial
cases of autosomal recessive male infertility.
相似文献
59.
Conway GS; Payne NN; Webb J; Murray A; Jacobs PA 《Human reproduction (Oxford, England)》1998,13(5):1184-1187
We have screened 132 women with premature ovarian failure for fragile X
(FRAXA) premutations. Three out of 23 (13%) pedigrees with the familial
premature ovarian failure and 3/106 (3%) of women with the sporadic form of
premature ovarian failure have FRAXA premutations compared with an expected
prevalence of 1:590 (P=0.02). The mechanism of the association between
FRAXA premutations and premature ovarian failure is unknown but as a
genetic marker, FRAXA screening will be particularly valuable in predicting
premature ovarian failure in some pedigrees and in the identification of
families at risk of transmitting fragile X syndrome.
相似文献
60.
通信兵智力水平与专业水平的关系 总被引:4,自引:0,他引:4
0 引言 智力在很大程度上决定着个体的作业绩效水平 [1 - 3] ,同时也是预测个体职业成就的一个重要指标 .因此 ,我们试图通过对通信兵智力的测量与分析 ,揭示通信兵智力与专业技术水平的关系以及通信兵重要岗位人员智力与专业技术水平的关系 ,为最终科学地建立通信兵职业适宜性测评体系奠定必要的工作基础 .1 对象和方法1.1 对象 某集团军通信团在岗专业技术人员 ,其中技术难度高的报、话务专业人员 6 3名 ,载波、接力等仅对仪器进行操作的专业人员 5 1名 ,外线、架设等一般专业人员 43名 ,共 15 7名 .工作 1a以上 ,年龄在 18~ 32岁之… 相似文献