Adolescent Psychotherapy Outcomes in Community Mental Health: How Do Symptoms Align with Target Complaints and Perceived Change?

This study examined the relationship between clinically significant symptom change (rated by youth and parents), severity of client-defined primary presenting problems (i.e., Target Complaints), and perceived change in therapy. Participants were 117 adolescents receiving outpatient therapy and their parents. Participants completed the following measures at intake and 3 months into treatment: Ohio Scales, Target Complaints, and Perceived Change. Results indicate significant correspondence between clinically significant symptom change and other outcomes, offering preliminary evidence that global symptom measures represent change that is meaningful to adolescent clients. However, the modest magnitude of the correspondence also suggests that such measures as perceived change and individualized Target Complaints may offer unique utility in capturing the multidimensional nature of outcomes in youth therapy and provide useful avenues for future research focused on enhancing client engagement and retention. Recommendations for outcome assessment in community mental health centers are provided.     

Parent and Adolescent Satisfaction with Mental Health Services: Does it Relate to Youth Diagnosis,Age, Gender,or Treatment Outcome?

Consumer satisfaction with treatment is important information for providers of mental health services. The goal of the current study was to examine the relationship between youth and parent satisfaction ratings and the following youth variables: gender, age, primary diagnosis, and changes in functioning and symptomatology after 6 months of services. Results demonstrated that in a large sample of youth receiving community mental health services satisfaction with services differed as a function of the adolescents’ clinician-derived primary diagnosis, age, and reported changes in symptoms and functioning. Although significant, these variables accounted for only a small portion of the variance in satisfaction. Additionally, the relationship between parent and youth ratings of satisfaction was low, but significant. The implications of these findings are discussed as well as future directions for clinicians and researchers.     

Hemoglobin M equon beta 41 (C7) phenylalanine leads to tyrosine

A severe hemolytic crisis was observed in a 34-yr-old female of English- Irish extraction following a viral illness treated with acetaminophen. Heinz bodies and heat instability were present only during a transient hemolytic event. A challenge dose of acetaminophen caused no detectable hematologic abnormality. Structural studies of the hemoglobin during hemolysis and again after complete recovery localized the abnormality to tryptic peptide beta Tp-5, and automated sequencing of I 125-labeled beta chains indicated a replacement of phenylalanine (C7) beta 41 by tyrosine. Substitution of the next residue, phenylalanine (CD1) beta 42 by serine (Hb Hammersmith), has resulted in chronic severe Heinz body hemolytic anemia. The lack of chronic anemia in the present disorder may reflect the different relationships of beta41 and beta 42 and/or the similarities in volume and hydrophobicity of tyrosine and phenylalanine. It is suggested that substitution of tyrosine for phenylalanine in Hb Mequon may disturb the critical environment around the heme group and render it susceptible to oxidative denaturation in the presence of infections and/or drugs.     

Eight-Year Experience with Minimally Invasive Cardiothoracic Surgery

Background  

Over the past decade, minimally invasive cardiac surgery (MICS) has emerged as an accepted approach for the management of cardiac disease that requires a surgical solution. We report the results of an 8-year, single-institution experience with MICS.