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排序方式: 共有406条查询结果,搜索用时 78 毫秒
41.
Iakovets IaV Iakovets EA Neĭmark AI Karpenko AA Arzamastsev DD 《Urologii?a (Moscow, Russia : 1999)》2011,(5):33-4, 36-9
Pain and abnormal spermatogenesis are among symptoms deteriorating quality of life in patients with chronic prostatitis. Rectal suppositories vitaprost have no side effects, relieve pain, correct spermatogenesis. The effect of vitaprost treatment persists for 3 months and longer. Prostatic arteries embolization with vitaprost suppositories as preoperative preparation is a good alternative to surgical treatment in patients with prostatic adenoma. 相似文献
42.
Lyudmila N. Antipenko Alexander V. Karpenko Sergey I. Kovalenko Andrew M. Katsev Elena Z. Komarovska-Porokhnyavets Vladimir P. Novikov 《Archiv der Pharmazie》2009,342(11):651-662
We report in this work the synthesis, cytotoxicity, and antimicrobial activity of ([1,2,4]triazolo[1,5-c]quinazolin-2-ylthio)carboxylic acid amides 4 – 7 in connection with our previous research in the preparation of triazoloquinazoline derivatives. Due to simplicity, general availability of starting materials, and high yields, the most reliable method of synthesis appeared to be the one with N,N-carbonyldiimidazole activation stage. The chemical structures of all obtained substances were deduced from FT-IR, 1H-NMR, EI-MS, and LC-MS spectral data. The results of cytotoxicity evaluated by bioluminescence inhibition of bacterium Photobacterium leiognathi, strain Sh1 showed that compounds 4.1 , 4.6 , and 6.1 were the most cytotoxic. Investigation of the antimicrobial and antifungal activity of amides 4 – 7 (concentration 5 mg/mL) was carried out by the stiff-plate agar-diffusion method. We found that the compounds possessed low ( 4.1 , 4.7 ) antifungal activity against Candida tenuis and strong ( 4.21 , 5.1 , 5.9 ) or inefficient ( 4.7 , 4.12 , 4.16 ) activity against Aspergillus niger. Substances 5.1 and 5.9 slightly affected Mycobacterium luteum. Staphylococcus aureus was resistant to all obtained substances, and only the n-butyramide derivatives 7.1 and 7.5 inhibited the growth of Escherichia coli. Hence, there was no strong correlation between bioluminescence inhibition and antimicrobial activity of the investigated substances. 相似文献
43.
Hiroaki Haruguchi Kotaro Suemitsu Naoko Isogai Masaaki Murakami Masahiko Fujihara Kazuhiro Iwadoh Jeremiah Menk Hiroko Ookubo Tomonari Ogawa the IN.PACT AV Access Investigators 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2023,27(4):682-693
Purpose
There is a lack of adjudicated and prospectively randomized published outcomes on the use of drug-coated balloons (DCB) to treat dysfunctional arteriovenous fistula in Asian patients. This post hoc subgroup analysis of 112 Japanese participants from the global IN.PACT AV Access trial reports outcomes through 12 months.Materials and Methods
Participants were treated with DCB (n = 58) or standard non-coated percutaneous transluminal angioplasty (PTA) balloons (n = 54). Outcomes included target lesion primary patency (TLPP), access circuit primary patency, and safety.Results
Through 6 months, TLPP was 86.0% (49/57) in the DCB group and 49.1% (26/53) in the PTA group (p < 0.001). Through 12 months, TLPP was 67.3% (37/55) in the DCB group and 43.4% (23/53) in the PTA group (p = 0.013).Conclusion
In this post hoc analysis of Japanese participants from the IN.PACT AV Access trial, participants treated with DCB had higher TLPP through 6 and 12 months compared with PTA. 相似文献44.
Kosul'nikov SO Karpenko SI Lobanov AA Kravchenko KV Tarnopol'skiĭ SA 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》2008,(2):22-23
The experience of treatment of patients for splenic abscess, using the abscess cavity puncture and drainage under ultrasonographic guidance, was summarized. The authors consider the method applied as a perspective one, noting, yet, its risks and a need for further studying. 相似文献
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A total of 43 patients with primary pulmonary hypertension were examined. The diagnosis was confirmed by invasive techniques and echocardiography. In addition to routine clinical studies, microcirculatory, central and pulmonary hemodynamic ones were used to examine the patients' status and to measure pulmonary pressure. Three groups of the patients were identified: (1) those who received UV-irradiated blood autotransfusion (n = 14); (2) those who underwent hemocarboperfusion with plasmapheresis (n = 15); (3) those who had their own drug therapy (n = 14). The immediate and long-term outcomes of the therapy were analysed. Indications were defined for the usage of extracorporeal techniques in the multimodality treatment of patients with primary pulmonary hypertension. 相似文献
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Combined virus-like particle-based polyepitope DNA/protein HIV-1 vaccine design, immunogenicity and toxicity studies 总被引:1,自引:0,他引:1
Karpenko LI Ilyichev AA Eroshkin AM Lebedev LR Uzhachenko RV Nekrasova NA Plyasunova OA Belavin PA Seregin SV Danilyuk NK Zaitsev BN Danilenko ED Masycheva VI Bazhan SI 《Vaccine》2007,25(21):4312-4323
We have previously described designing of polyepitope immunogens TBI and TCI, to stimulate the humoral and cellular immune responses to HIV-1. Here, immunogens TBI and TCI were used to create new vaccine construct named CombiHIVvac (Combined HIV-1 vaccine). CombiHIVvac is a virus-like particles (VLP) containing the DNA vaccine pcDNA-TCI as a core encapsulated within a spermidine-polyglucin-TBI conjugate. The immunogenic and toxic properties of the candidate vaccine CombiHIVvac have been studied. CombiHIVvac induces a strong humoral and CTL responses in mice; the antibodies are highly specific and are able to neutralize HIV-1 in vitro. Preclinical study demonstrated that CombiHIVvac does not cause long-term changes in physiological, biochemical and morphological parameters in immunized animals and thus can be recommended for clinical trials. 相似文献
50.