全文获取类型
收费全文 | 5832篇 |
免费 | 297篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 228篇 |
妇产科学 | 175篇 |
基础医学 | 682篇 |
口腔科学 | 127篇 |
临床医学 | 402篇 |
内科学 | 1133篇 |
皮肤病学 | 137篇 |
神经病学 | 325篇 |
特种医学 | 108篇 |
外科学 | 1031篇 |
综合类 | 185篇 |
一般理论 | 3篇 |
预防医学 | 499篇 |
眼科学 | 185篇 |
药学 | 527篇 |
中国医学 | 34篇 |
肿瘤学 | 292篇 |
出版年
2023年 | 58篇 |
2022年 | 141篇 |
2021年 | 253篇 |
2020年 | 161篇 |
2019年 | 190篇 |
2018年 | 231篇 |
2017年 | 148篇 |
2016年 | 186篇 |
2015年 | 198篇 |
2014年 | 228篇 |
2013年 | 302篇 |
2012年 | 478篇 |
2011年 | 456篇 |
2010年 | 261篇 |
2009年 | 189篇 |
2008年 | 289篇 |
2007年 | 276篇 |
2006年 | 260篇 |
2005年 | 263篇 |
2004年 | 219篇 |
2003年 | 208篇 |
2002年 | 200篇 |
2001年 | 82篇 |
2000年 | 73篇 |
1999年 | 70篇 |
1998年 | 40篇 |
1997年 | 26篇 |
1996年 | 18篇 |
1995年 | 25篇 |
1994年 | 19篇 |
1993年 | 24篇 |
1992年 | 48篇 |
1991年 | 40篇 |
1990年 | 34篇 |
1989年 | 37篇 |
1988年 | 40篇 |
1987年 | 25篇 |
1986年 | 28篇 |
1985年 | 29篇 |
1984年 | 36篇 |
1983年 | 25篇 |
1982年 | 16篇 |
1981年 | 22篇 |
1980年 | 26篇 |
1979年 | 9篇 |
1977年 | 16篇 |
1976年 | 19篇 |
1972年 | 10篇 |
1966年 | 10篇 |
1931年 | 8篇 |
排序方式: 共有6150条查询结果,搜索用时 15 毫秒
951.
Eid Ebrahem M. Shaltout Kamal H. Abdallah Samy M. Galal Tarek M. El-Bebany Ahmed F. Sewelam Nasser A. 《Bulletin of environmental contamination and toxicology》2020,104(1):134-143
Bulletin of Environmental Contamination and Toxicology - This study was carried out to develop mathematical regression equations for predicting the uptake of ten heavy metals (HMs) (cadmium, Cd;... 相似文献
952.
Mona Kamal David I. Rosenthal Stefania Volpe Ryan P. Goepfert Adam S. Garden Katherine A. Hutcheson Karine A. Al Feghali Mohamed Ahmed Mohamed Meheissen Salman A. Eraj Amy E. Dursteler Bowman Williams Joshua B. Smith Jeremy M. Aymard Joel Berends Aubrey L. White Steven J. Frank William H. Morrison G. Brandon Gunn 《Radiotherapy and oncology》2018,126(1):75-80
Purpose
To identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN).Methods
Head and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test the prediction power of each tool for EQ-5D VAS. The modified Breiman recursive partitioning analysis (RPA) was used to identify a cut point of the MDASI-HN dry mouth score (MDASI-HN-DM) with EQ-5D VAS, using a ROC-based approach; regression analysis was used to confirm the threshold effect size.Results
Two-hundred seven respondents formed the cohort. Median follow-up from the end of RT to questionnaire completion was 88?months. The single item MDASI-HN-DM score showed a linear relationship with the XQ composite score (ρ?=?0.80, p?<?0.001). The MDASI-HN-DM displayed improved model performance for association with EQ-5D VAS as compared to XQ (BIC of 1803.7 vs. 2016.9, respectively). RPA showed that an MDASI-HN-DM score of ≥6 correlated with EQ-5D VAS decline (LogWorth 5.5).Conclusion
The single item MDASI-HN-DM correlated with the multi-item XQ and performed favorably in the prediction of QOL. A MDASI-HN-DM cut point of ≥6 correlated with decline in QOL. 相似文献953.
Vincent T. Ma Philip S. Boonstra Kamal Menghrajani Cecelia Perkins Krisstina L. Gowin Ruben A. Mesa Jason R. Gotlib Moshe Talpaz 《Clinical Lymphoma, Myeloma & Leukemia》2018,18(5):e201-e210
Introduction
In the era before Janus kinase (JAK) inhibitors, cytogenetic information was used to predict survival in myelofibrosis patients. However, the prognostic value of cytogenetics in the setting of JAK inhibitor therapy remains unknown.Patients and Methods
We performed a retrospective analysis of 180 patients with bone marrow biopsy–proven myelofibrosis from 3 US academic medical centers. We fit Cox proportional hazards models for overall survival and transformation-free survival on the bases of 3 factors: JAK inhibitor therapy as a time-dependent covariate, dichotomized cytogenetic status (favorable vs. unfavorable), and statistical interaction between the two. The median follow-up time was 37.1 months.Results
Among patients treated with best available therapy, unfavorable cytogenetic status was associated with decreased survival (hazard ratio = 2.31; P = .025). At initiation of JAK inhibitor therapy, unfavorable cytogenetics was (nonsignificantly) associated with increased survival compared to favorable cytogenetics (hazard ratio = 0.292; P = .172). The ratio of hazard ratios was 0.126 (P = .034). These findings were similar after adjusting for standard clinical prognostic factors as well as when measured against transformation-free survival.Conclusion
The initiation of JAK inhibitor therapy appears to change the association between cytogenetics and overall survival. There was little difference in survival between treatment types in patients with favorable cytogenetics. However, the use of JAK inhibitor therapy among patients with unfavorable cytogenetics was not associated with worse survival compared to favorable cytogenetics. Our analyses suggest that initiation of JAK inhibitor therapy nullifies the negative prognostic implication of unfavorable cytogenetics established in the pre–JAK inhibitor therapy era. 相似文献954.
955.
Amr Farouk Ibrahim Moustafa Eman Faker Kamal Maher M. Hassan Mona Sakr Mohammed Mohammed Mohammed Gomaa 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):259-264
Objective
To evaluate the additive value of Contrast Enhanced Spectral Mammography (CESM) in the preoperative assessment of malignant lesions in dense breast parenchyma regarding multiplicity.Material and methods
The study included 160 women having heterogeneous dense breast parenchyma (ACR c and d) with suspicious lesions identified on sono mammography examination. All patients performed contrast enhanced spectral mammography to confirm or exclude lesion multiplicity. The number of lesions was calculated in the contrast high energy subtraction images with the reference standard being histopathological analysis.Results
Adding CESM to sono-mammography the accuracy in identifying multiple malignant lesion increased from 81.8% accuracy of sono-mammography up to 100% accuracy after adding CESM.Conclusion
Contrast enhanced spectral mammogram showed an added value in the preoperative assessment of breast masses increasing the accuracy of detection of lesions and multiplicity (multifocality and multi-centricity). 相似文献956.
Neal A. Palafox Leslie Given Karin Hohman John Ray Taitano Johnny Hedson Lee E. Buenconsejo-Lum Kamal Gunawardane Janos Baksa Martina Reichhardt 《Cancer causes & control : CCC》2018,29(12):1287-1295
Introduction
In the early 1990s, a comprehensive cancer control (CCC) approach was developed in the United States (US). In 2003, the US-Affiliated Pacific Islands (USAPI) adopted the CCC approach through a regional coalition, the Cancer Council of the Pacific Islands (CCPI). Using the CCC approach, the CCPI developed jurisdiction-specific cancer coalitions and initiated their respective cancer plans.Methods
The evolution of the CCC approach and the history of the CCPI regional coalition are reviewed. The outcomes of the regional approach for cancer control in the USAPI are described to illustrate the possibilities, value-added and innovation of using a CCC strategy in a multi-national coalition based in a resource-limited environment.Results
The CCC approach enabled the CCPI to (1) harmonize cancer control efforts between the six USAPI jurisdictions, (2) represent the USAPI cancer needs as a single voice, and (3) develop a regional cancer control strategy. Outcomes include (1) a regional cancer registry, (2) three sequential regional CCC plans, (3) leveraged resources for the USAPI, (4) enhanced on-site technical assistance and training, (5) improved standards for cancer screening, (6) evidence-based cancer control interventions adapted for the USAPI.Conclusion
The regional CCPI coupled with the CCC approach is an effective engine of change. The CCC strategies enabled navigation of the political, geographic, cultural, and epidemiologic Pacific environment. The regional partners have been able to harmonize cancer control efforts in resource-limited settings. Regional cancer coalitions may be effective in the global arena for cancer control between communities, states, or countries.957.
The effect of acetylcholine, 3,4-dihydroxyphenylethylamine, prostaglandin (PGE1), guanosine triphosphate (GTP), and divalent ions on adenylate cyclase activity in homogenates of "differentiated" and malignant mouse neuroblastoma cells was studied. The sensitivity of adenylate cyclase to acetylcholine and 3,4-dihydroxyphenylethylamine markedly increased in adenosine cyclic 3:5-monophosphate-induced differentiated neuroblastoma cells. Although 3,4-dihydroxyphenylethylamine stimulated adenylate cyclase activity in malignant neuroblastoma cells, it failed to do so in X-irradiation induced differentiated cells. PGE1 and GTP stimulated adenylate cyclase activity in malignant and adenosine cyclic 3:5-monophosphate induced differentiated neuroblastoma cells to about the same level. GTP protentiated the PGE1 effect in differentiated concentrations of magnesium and manganese inhibited adenylate cyclase activity; this effect was more pronounced in differentiated cells than in malignant cells. Calcium stimulated adenylate cyclase activity in malignant and differentiated cells to about the same level. There was no significant difference in the values of Km and Vmax of neuroblastoma cells. This study shows that the sensitivity of adenylate cyclase to neurotransmitters and divalent ions (magnesium and manganese) and the sensitivity of PGE1 stimulated enzyme activity to GTP increase in adenosine cyclic 3:5-monophosphate-induced differentiated neuroblastoma cells. Therefore, we suggest that the reverse may be true during malignant transformation of nerve cells. 相似文献
958.
959.
960.
Rahmouni K 《Clinical and experimental pharmacology & physiology. Supplement》2007,34(Z1):S8-S10
1. Leptin is a hormone that is secreted by adipocytes and delivered to the brain to regulate appetite and energy expenditure. Other effects of leptin include activation of the sympathetic nervous system and an increase in arterial pressure.2. Mounting evidence suggests that the sympathetic nervous system subserving different tissues is differentially controlled by leptin. For instance, leptin-induced regional increases in sympathetic nerve activity do not respond uniformly to baroreflex activation and hypothermia.3. In several mouse models of obesity, the ability of leptin to increase renal sympathetic nerve activity is preserved, despite resistance to leptin's effect on food intake, body weight and thermogenic sympathetic tone. Furthermore, obese mice also retain the increase in arterial pressure in response to leptin.3. Although they display a lack of metabolic responses to leptin, animal models of obesity preserve renal sympathetic and arterial pressure responses that potentially cause the adverse cardiovascular consequences of obesity. Thus, it is possible that excess leptin contributes to cardiovascular complications, even when a subject shows metabolic resistance to leptin. 相似文献