Effects of rifampicin on the peripheral turnover kinetics of thyroid hormones in mice and in men

The induction of mixed function hepatic oxygenases by rifampicin is known to increase the metabolic clearance rate (MCR) of T4. By performing T3 and rT3 kinetics we have shown that rifampicin also increases the MCR of T3 and rT3. Using the fall of serum T4 during TSH suppression as an indirect marker of the production rate (PR) of T4, we have demonstrated that there was no major change in monodeiodination nor any shift to either 5'- or 5-monodeiodination. Rifampicin stimulates in mice the mixed function hepatic oxygenases. However, we were unable to increase hepatic deiodinase activity (deiodinase type I) in this species. It is therefore possible that the increased MCR of T4 in man is not mediated by an increased conversion rate either. As mixed function hepatic oxygenases are known to increase hepatic conjugation it is suggested that rifampicin increases the biliary excretion of iodothyronine conjugates.     

缺血性脑血管病与颈动脉粥样硬化及其危险因素的关系

目的探讨缺血性脑血管病(ICVD)与颈动脉粥样硬化及其危险因素的关系。方法对186例ICVD患者与194例非脑血管病患者和正常体检者(对照组)行颈部血管超声检查和血液生化检查;比较两组间的颈动脉硬化程度及脑卒中危险因素的差异。结果ICVD组年龄[(69±7)岁]和患有高血压(66.1%)、糖尿病(53.4%)、代谢综合征患者(44.6%)的比率非常明显高于对照组[(61±5)岁、48.8%、15.2%、12.9%](均P<0.001)。ICVD组颈动脉粥样硬化分级计分≥2分(斑块发生率)、≥3分(血管狭窄发生率)分别为69.3%、20.4%,明显高于对照组的33.5%和5.1%(均P<0.05)。结论颈动脉粥样硬化是ICVD的危险因素之一;各种危险因素的聚集对ICVD的发生起重要作用。     

当前PCO行业和市场问题的浅析

广州鼠害与卫生虫害防治协会(以下简称协会)成立于2001年5月18日,截止2003年11月31日止,现有团体会员238个(其中厂家9个),个人会员93个,在团体会员中,领有灭鼠杀虫服务资质证有220个(其中街镇124个占56%,社会PCO公司96个占44%),从事灭鼠杀虫的从业人员近1 600人.2002、2003年已进行"病媒生物防治工"职业培训,并领取中华人民共和国职业资格证书共1 354人,除去外地区22人,实际本市1 332人,占从业人员的83.3%,以后每年都进行初级、中级的培训.协会作为行业协会"应定位在自律性行业管理组织上,应以服务为宗旨,同时做好自律、协调、监督工作"."改革逼使我们尽快培育和发展行业协会,使行业协会的作用真正得到发挥,并承担起政府转移出去的一些职能".协会成立二年来,为政府、社会、会员的服务中在市爱卫办的指导和会员单位的大力支持下,摸着石头过河,取得了一点成绩,但我市协会在实际工作中,碰到一些急待探讨的问题,部分问题通过协会的自治管理是可以解决的,有些问题不是协会本身能解决的.     

Factors affecting the neonatal response to artificial surfactant

Objective : To define the individual neonatal response to the artificial surfactant, Exosurf, and factors that may influence the response.
Methodology : Eighty-two consecutive, preterm neonates with respiratory distress syndrome, who received Exosurf at <12h of age were studied. Their response was categorized from the graphical change in the oxygenation index with postnatal age, for 12h after each of two doses of surfactant and assessed independently by two observers. Clinical factors were analysed for their effect on the four pre-defined categories of response, namely: none; mild; good; relapsed; and good: sustained.
Results : Within the first 12h, 11% of the neonates showed no response, 5% a mild response and 84% a good response, but 34% relapsed. By 24h, 6% still showed no response (all died), 11% showed a mild response and 83% a good response, of whom half relapsed. At 24h, no response was significantly associated with low gestational age and asphyxia mild response with less severe lung disease. According to the response there was a gradation in the risk of death during the first week.
Conclusions : The response to Exosurf can be individually and reproducibly categorized and demonstrated that 83% of neonates had a good response but half relapsed. No response was associated with extreme prematurity and asphyxia     

Construct Validity of a Clinical-performance-evaluation Tool in Community Health Nursing

An evaluative research study was conducted to examine the construct validity and applicability of a selected clinical-performance-evaluation tool. The tool was designed for baccalaureate students in a community health nursing course. Eighteen senior students functioning in two urban clinical agencies participated in the study. Data were collected at two evaluation points over one semester. Results indicated strong support for construct validity of the tool. This finding suggests a high level of correlation between theoretical concepts and clinical practice. Recommendations for use of the clinical performance evaluation tool are discussed.     

Infrared coagulation in lung surgery

Infrared coagulation (IRC) is a reliable method to stop surgical bleeding from the thoracic wall and proves to be superior to other forms of coagulation in this area. In pulmonary parenchyma IRC is used for sealing of parenchymal surfaces after atypical resections. Emphysematous bullae may be coagulated with IRC instead of over-swan. A main advantage in using IRC is that the surgical area not necessarily needs to be "dry" for application of IRC. Forced pressing of the IRC-applicator against the tissue prevents dissipation of light energy via running blood. There are no superficial carbonisations, instead there is coagulation inside the tissue.     

大鼠肠系膜淋巴结高内皮微静脉与淋巴迷路之间的网状纤维支架的研究

目的 研究大鼠肠系膜淋巴结内高内皮微静脉与淋巴迷路之间淋巴细胞归巢的通路.方法 用镀银染色光镜观察法和冻裂割断扫描电镜观察法观察健康、成熟Wistar大鼠肠系膜淋巴结的基质网状结构.结果 位于高内皮微静脉和淋巴迷路周围有网状纤维支架,在二者相临近部位有密集交织的网状纤维网.结论 淋巴结内高内皮微静脉和淋巴迷路之间密集交织的网状纤维网,为细胞的居留和迁移提供结构支持和适宜的微环境,可能是淋巴细胞归巢的重要通路.     

树突状细胞在胆囊癌组织内浸润的研究

目的通过对胆囊癌组织中树突状细胞浸润情况的研究,阐述树突状细胞与肿瘤免疫之间的关系。方法采用免疫组化SP法。结果树突状细胞在胆囊癌组织的浸润程度与年龄、性别和病理组织学类型无关,与病理分化程度呈负相关关系(P<005)。结论树突状细胞在胆囊癌组织的浸润程度与病理分化程度、Nevin分期、肝浸润及淋巴结转移存在密切的关系。树突状细胞的定量检测可作为估计胆囊癌预后的标志。     

Systematic isolation of transducing phages for Myxococcus xanthus.

Six new phages active on Myxococcus xanthus have been isolated from cultures of myxobacteria. The six are all capable of transduction, and they fall into three groups. Members of one group have long contractile tails, have a characteristic neutralization antigen, and resemble the previously described M×4. Members of a second group, exemplified by M×8, have very short tails and a characteristic antigen. M×9, the sole member of the third group, has a very short tail and a characteristic antigen. Phage M×8, which is active on fruiting as well as nonfruiting strains of M. xanthus, can transduce auxotrophic, antibiotic resistance and motility markers in M. xanthus. Although crude lysates of M×8 contain 58-nm diameter particles with a tail and 29-nm particles without tail, only 58-nm particles can form plaques and transduce. The plaque-forming particles of M×8 possess a single DNA molecule of 56,000 base pairs with a buoyant density of 1.726 g/cm³, virtually identical to that of the DNA from its host.