项目记忆和源记忆的功能磁共振成像研究

目的探讨项目记忆和源记忆的神经基础及其是否存在性别差异。方法健康男女各8名，实验材料为504个高频双汉字词，项目记忆和源记忆实验任务，Block设计，GE1．5T采集功能磁共振成像（mRI）数据，用SPM99分析，得到男女脑功能激活图（P〈0．002，体素块〉20）。结果在P〈0．002，体素块〉20时，女性项目记忆激活双前额叶背外侧BA6（激活数目左右侧分别为62和11个），源记忆较多激活左前额叶背外侧BA6／46（激活数目为59个）；男性项目记忆激活右前额叶背外侧BA6／46（激活数目为64个），源记忆激活双前额叶背外侧BA6（左右侧分别为9和40个）。结论项目记忆更多激活右侧前额叶背外侧，而源记忆更多激活左侧前额叶背外侧。女性较多地引起左前额叶背外侧激活；而男性较多地引起右前额叶背外侧激活。     

金针菇生物活性物质结构与功能的研究进展

金针菇Flammulina velutipes含有多种生物活性物质,具有很高的药用价值。总结了近年来金针菇中火菇素(flammulin)、溶细胞素(flammutoxin)、免疫调节蛋白(Fip-fve)、抗病毒蛋白、跨上皮电抗性蛋白(TEER-TDP)和金针菇多糖(FVP)的研究进展。     

In vivo activity and metabolic fate of 2-(2,3,3-triiodoallyl)tetrazole (ME1401), a novel antifungal agent

2-(2,3,3-Triiodoallyl)tetrazole (ME1401), a novel antifungal agent, showed therapeutic effectiveness in topical treatment of experimental dermal infections with Trichophyton mentagrophytes and Candida albicans in guinea-pigs. Addition of diethyl sebacate to the ME1401 preparations increased its in vivo antifungal activity and its penetration into the skin. When the estimation of efficacy of treatment with active formulations was made on the basis of skin lesion and the rate of negative skin cultures in comparison with those for infected, untreated or placebo-treated controls, the in vivo activity of 0.5% ethanol tincture or gel of ME1401 was comparable to that of reference antimycotic drugs such as clotrimazole, haloprogin and others. Pharmacokinetic studies in the experimental animals demonstrated that ME1401 was unstable in vivo, being readily converted to an active metabolite 2-(3-iodopropargyl)tetrazole (CN144) first and then to 2-propargyltetrazole (CN151). CN144 showed potent in vitro and in vivo antifungal activities, while the in vitro activity of CN151 was negligible.     

人参茎叶总皂甙对实验性小鼠生殖细胞遗传物质损伤的影响

本文采用小鼠精原细胞姐妹染色单体互换（ＳＣＥ）实验方法，研究了人参茎叶总皂甙（ＧＮＳ）对丝裂霉素Ｃ（ＭＭＣ）引起的小鼠精原细胞遗传物质损伤的影响。结果表明，ＧＮＳ不能诱发小鼠精原细胞ＳＣＥ，而且在腹腔注射ＭＭＣ的同时给予ＧＮＳ，可使ＭＭＣ诱发的小鼠精原细胞ＳＣＥ频率明显降低。为此，我们认为ＧＮＳ对小鼠生殖细胞遗传物质具有保护作用。     

Diastematomyelia presenting as progressive weakness in an adult after spinal fusion for adolescent idiopathic scoliosis.

BACKGROUND CONTEXT: Diastematomyelia is uncommon and rarely presents in adulthood. This report draws attention to the fact that patients who underwent spinal fusion for deformity before the widespread use of computed tomography (CT) and magnetic resonance imaging (MRI) may have unrecognized spinal cord abnormalities. This should be considered if revision surgery is contemplated. PURPOSE: This case report focuses on the late presentation of lower-extremity weakness in a 44-year-old woman with a split cord malformation (diplomyelia), diastematomyelia and tethered cord syndrome. STUDY DESIGN/SETTING: METHODS: The patient underwent instrumented posterior spinal fusion with a Harrington rod as a child for progressive thoracolumbar scoliosis. As an adult, she developed paraparesis after a traumatic event.The patient underwent decompressive laminectomy, subtotal resection of the old fusion mass and resection of the osseous septum. Postoperatively, an anterior spinal fluid leak in the lower thoracic region required repeated fascial grafting, resection of a pseudomeningocele and reverse left latissimus dorsi flap transfer. The leak was controlled, and the patient had near complete resolution of her paraparesis 1 year after her surgery. RESULTS: The case described herein is unusual in that patients with diplomyelia and diastematomyelia rarely are symptomatic in adulthood. However, trauma may precipitate the onset of neurologic symptoms. This patient underwent spinal surgeries to address deformity, pain and progressive lower-extremity weakness. Preoperative CT and MRI studies showed a split cord malformation and diastematomyelia at L1-L2 with spinal stenosis and tethering of both hemicords. CONCLUSIONS: Progressive weakness without any previous neurologic deficit or neurocutaneous stigmas of an underlying spinal cord abnormality may develop in the adult with unrecognized diastemotomyelia. This case demonstrates that a thorough preoperative workup of patients with complex spinal deformities is imperative.     

前臂桡侧复合血管网皮瓣的临床应用

目的　报道前臂桡侧神经血管复合岛状皮瓣的解剖方法及临床应用效果。　方法　对手部创面及瘢痕挛缩以该皮瓣进行修复 2 2例 2 3处 ,切取皮瓣面积最大 13cm× 6cm ,最小 8cm× 4cm ,旋转点至皮瓣顶端最长 2 2cm ,旋转点设计在鼻烟窝或其近端 ,蒂部及皮瓣下筋膜中含有桡神经浅支、头静脉及桡动脉鼻烟窝上行支 ,含或不含前臂外侧皮神经。　结果　临床应用 2 2例 2 3块皮瓣 ,其中皮瓣全部成活 2 2块 ,部分坏死 1块。术后随访 1～ 3个月 ,成活的皮瓣质地优良 ,外观比较满意。　结论　前臂桡侧复合皮瓣的临床应用 ,皮瓣切取面积大 ,旋转点更远 ,可达手部较远端创面 ,给手部创面的修复提供了一种新选择。     

夜间电子生物阻抗测量装置对阴茎勃起功能障碍的检测

目的 :探讨夜间电子生物阻抗测量装置 (NEVA)在阴茎勃起功能障碍的诊断中的应用价值。方法 :对 4 1例主诉阴茎勃起功能障碍者 (障碍组 ) 19例主诉无勃起功能障碍但有射精障碍者 (无障碍组 )进行NEVA检测。结果 :障碍组夜间试验中的夜间勃起的次数、阴茎勃起的最大体积改变、最长持续时间等客观指标均要差于无障碍组 ,差异有统计学意义 (P <0 .0 1)。结论 :NEVA为非侵入性检测、可鉴别心理性阴茎勃起功能障碍和严重的器质性勃起功能障碍 ,且对勃起功能障碍的定性和定量具有一定的客观性。     

舒利迭加无创通气治疗稳定期慢性阻塞性肺疾病的临床研究

目的探讨舒利迭(吸入型肾上腺皮质激素与长效β2-受体激动剂的预混制剂)联合双水平气道正压通气(B iPAP)对稳定期慢性阻塞性肺疾病(COPD)的治疗作用。方法稳定期COPD病人52例,舒利迭TM50/250,1吸/次,2次/d;B iPAP,吸气压力(IPAP)10~20cm H2O,呼气压力(EPAP,也称PEEP)3~6cm H2O,吸氧浓度(FiO2)3L/m in,每天夜间通气6~8h。观察治疗前、治疗后12周病人临床症状、生活质量、健康状态和肺功能。结果治疗前、治疗后12周病人的临床症状、急性加重次数及严重程度、健康状态和生活质量、肺功能等指标比较差异有统计学意义(P<0.05)。结论舒利迭联合B iPAP治疗稳定期COPD病人能够明显改善其症状,提高生活质量,有一定的临床应用价值,对减缓COPD病人肺功能下降有积极意义。     

Balloon dilation for ureteral stricture with stone fragments after ESWL]

We treated 5 cases of severe hydronephrosis with balloon dilation. Those hydronephrosis were due to the ureteral stricture with small stone fragments after ESWL (Lithostar). In each case, in situ ESWL had been done on a long-lodged ureteric stone with severe hydronephrosis. And even after the disintegration of stone with ESWL, hydronephrosis remained due to ureteral stricture with small stone fragments. Balloon dilation was done through percutaneous nephrostomy tract in 4 cases and via retrograde transurethral routine in 1 case. Balloon dilation catheter (7 fr. 6 mm diameter 4-10 cm length, Bard Co.) was used. There was no need for stone extraction. After dilation, ureteric stents (8.2/7 fr.) were kept in place for 4-8 weeks. Intravenous urogram was taken on 4-8 weeks after removing ureteric stents. In all of the 5 cases, improvement of hydronephrosis was remarkable. And there was no residual stone fragments in 4 cases. It is concluded that balloon dilation for ureteral stricture with stone fragments after ESWL is very useful. For the valid evaluation of balloon dilation, further experience and longer observation are requisite.