Flow Pattern Analysis of the Baylor Total Artificial Heart

Abstract: To obtain an optimal design of the left blood chamber of the total artificial heart (TAH), flow visualization studies were performed. Information on velocities in critical areas of the left chamber was gathered using sectional pulsed laser light. The flow patterns on the entire pumping duration were photographed frame by frame. The inflow port, the opposite of the inflow and outflow of the pump (bottom area), and the diaphragm/ housing junction were the focal areas. The pump conditions, such as chamber pressure, preload and afterload pressure, pumping rate and roller screw, and displacement were recorded. Major stagnations and a low washout effect were observed in the bottom region. The closing of the inflow valve was irregular. In order to solve this problem, the inflow valve angle was changed 20 degrees. A comparison study showed a better valve closing characteristic, and no stagnation areas were observed with this new valve angle. Various velocity profiles confirmed the results. The valve closing characteristic is described in relationship to back flow.     

Early Afterdepolarization Abolished by Potassium Channel Opener in a Patient with Idiopathic Long QT Syndrome

Abolished Early Afterdepolarization by Nicorandil. We describe a 17-year-old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased KAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.     

Clinical Study of Cyclocytidine in Children With Acute Leukemia

One hundred children with various types of leukemia were given113 treatments with cyclocytidine. Eighty-four of these patientshad been treated previously. Cyclocytidine was daily given intravenouslyfor four to 11 consecutive days in amounts of 20mg/kg or 500mg/m².The treatment course . was repeated, when necessary. Complete remission was obtained in one case of monocytic leukemiaamong six treated by cyclocytidine alone. Combined therapy withsteroid hormone gave 14 complete and eight partial remissionsin 38 cases, the remission rate standing at 58%. There were30 complete and 16 partial remissions in 69 cases treated withcombination therapy with two or more agents, and the remissionrate was 67%. Transient pains in the region of the parotid gland were themost characteristic toxicity. GI tract symptoms were less commonand milder than those of cytosine arabinoside. Dizziness wasnoticed in three cases. Nine children with acute leukemia who were given cyclocytidineorally showed no remarkable response. Cyclocytidine, given parenterally, seems beneficial for varioustypes of leukemia in children.     

A Case of Pancreatic Cancer With Liver Metastasis Which Responded to Chemotherapy

A case of pancreatic cancer with liver metastasis is reported,in which chemotherapy had a marked effect, with the responsesclearly documented. The patient was a 59-year-old male who experienced epigastricpain in February 1985, upper gastrointestinal X-ray examinationrevealing extragastric compression by the pancreas. He visitedthe National Cancer Center Hospital, Tokyo, in April 1985 andthe diagnosis of pancreatic cancer with liver metastasis wasmade using the imaging procedures of ultrasonography, computedtomograph scanning and endoscopic retrograde cholangiopancreatographyas well as by biochemical and serological tests. At the timea 5 cm tumor was palpable in the middle upper abdomen. The patient was treated with Cis-diaminedichloro platinum, tegafur,and 5-fluorouracil, successively, and the abdominal tumor graduallydiminished, finally becoming impalpable. The response was evaluatedas one of partial responses (PR) by ultrasonography, and theimprovement substantiated by computed tomography and tumor markers.     

Neonatal Plesiomonas shigelloides septicemia and meningitis: A case and review

A 3 day old neonate with septicemia and meningitis due to Plesiomonas shigelloides is described. We could not detect the source of this infection. The patient was treated with cefotaxime and survived without sequelae. Nine previously reported cases with this infection were reviewed.     

硝吡咯菌素菌种选育

目的把一种新的方法应用于提高硝吡咯菌素工业生产菌株的生产能力。方法在硝吡咯假单胞菌中引入氨基糖苷类抗生素抗性突变 ,以提高硝吡咯菌素的生产能力。结果从含 3倍和 1 0倍MIC抗生素的GYM筛选平板上挑取抗性突变株 ,挑选出产抗能力提高 5倍以及 1 0倍以上的突变株 ;引入链霉素抗性突变对提高硝砒咯菌素的生产能力的效果最佳 ;Geniticin和庆大霉素的抗性突变对提高抗生素生产能力的效果较差 ;潮霉素抗性突变对提高抗生素生产能力具有一定的效果。结论引入氨基糖苷类抗生素抗性突变 ,可以有效提高硝吡咯菌的生产能力。     

食物过敏动物模型中肝脏的变化

目的　研究食入过敏原后肝脏的变化。方法　试验分为 2组 ,实验组小鼠用卵蛋白 (OVA)致敏 ,OVA(2g/L)经肠道攻击 3h后采血及肝脏 ,用酵素法测定血清中ALT(Alanineaminotransferase) ,并对肝样本进行H&E染色及免疫组织化学染色。结果　实验小鼠血清ALT浓度与对照组比较增高 ,P值有显著差异 (P <0 .0 1 ) ;实验组小鼠肝脏组织H&E染色可见大量炎性细胞浸润及巢状肝细胞坏死 ,免疫组织化学染色显示在OVA致小鼠的肝组织中 ,IL 4及IL 6阳性细胞数明显高于对照组。结论　在食物过敏反应中 ,肝脏也是一个受损害的脏器