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1.
Palat Balachandran M.S. M.Ch. Shaleen Agarwal M.S. M.Ch. Narendra Krishnani M.D. Chandra M. Pandey Ph.D. Ashok Kumar M.S. M.Ch. Sadiq S. Sikora M.S. Rajan Saxena M.S. Vinay K. Kapoor M.S. 《Journal of gastrointestinal surgery》2006,10(6):848-854
The aim of this study was to examine the predictors of long-term survival (>24 months) in patients with gall bladder cancer.
A retrospective review of 117 cases of gall bladder cancer resected between 1989 and 2000. The resections included 80 simple
cholecystectomies and 37 extended procedures. Patients with survival >24 months (n=44) were compared with those having survival
<24 months (n=73) for 17 prognostic factors. Overall median survival was 16 months with a 5-year survival of 27%. T status
(P=.000) and adjuvant chemoradiotherapy (P=.001) were independent predictors of long-term survival. Survival advantage was
seen in T3N+ve disease (P=.007) with extended procedures. Complete (R0) resection was attained in 30 patients with a 5-year
survival advantage of 30% as compared with incomplete (R1) resection (P=.0002). Adjuvant chemoradiotherapy improved survival
in simple cholecystectomy group (P=.0008) but no advantage was seen after extended procedures. Stage III (P=.001) and node-positive
disease (P=.0005) had significant benefit with adjuvant therapy. Poor differentiation and vascular invasion were associated
with poor long-term survival. R0 resection was associated with prolonged survival. Extended procedures improved survival in
patients with T3N+ve disease. Addition of chemoradiotherapy made significant improvement in long-term survival in stage III
and node-positive lesions and in patients undergoing simple cholecystectomy. R0 resection predicted long-term survival in
gall bladder cancer. T3 N+ve disease had better survival after extended procedures. Adjuvant chemoradiotherapy improved survival
in stage III and node-positive disease. Poor differentiation and vascular invasion were adverse predictors of survival. 相似文献
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A C Pandey 《Ecotoxicology and environmental safety》1988,15(2):221-225
Histomorphological responses of the ovary of a freshwater percoid fish, Colisa (T.) fasciatus, to endosulfan or thiodan EC 35 treatment, a popular pesticide, have been described. In addition, general behavioral changes of the fishes after treatment have also been recorded. Adult sexually mature females were used in the present study and all fish were in the prespawning phase of the ovarian cycle. The experiment was conducted under natural room temperature and day-night length for 30 days. Experimental fish were maintained in 1 ppm endosulfan solution, which was changed on alternate days after feeding with minced goat liver. Treated fish revealed that (a) the ovarian activity was retarded; (b) the ovarian wall became thicker; (c) the diameter of oogonia and stage I oocytes was not altered but that of stage II and III oocytes was greatly reduced; (d) the percentage of oogonia, stage I, and atretic oocytes increased considerably but that of stage II and III oocytes diminished significantly; and (e) yolk in the stage III oocytes appeared clumped and damaged. 相似文献
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H Pandey 《Journal of tropical pediatrics》1991,37(5):235-239
Integrated Child Development Services (ICDS) is India's most comprehensive programme to increase the survival rate and enhance the health, nutrition, and learning opportunities of pre-school children and their mothers through a package of services. The present study was carried out to measure the impact of the preschool education component of the ICDS on the cognitive development of children in the age group of 3-5 years. The study design used was case/control (ICDS attending children v. Non-ICDS). Results of the study revealed the ICDS Anganwadi attendance had positive influence on the cognitive development of children. The mean cognitive score of the attenders was 40.7 as against a mean score of 30.3 in the case of non-attenders. 相似文献
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Cyclohexanone was condensed with N-hydroxymethyl benzamide in conc. sulphuric acid to give alpha-methyl-benzamido-cyclohexanone (I). The reaction of (I) with thiosemicarbazide in ethanol resulted in alpha-methyl-benzamido-cyclohexanone thiosemicarbazone (II). Condensation of (II) with various aromatic aldehydes in the presence of ethanol afforded alpha-methyl-benzamido-alpha'-substituted-styryl-cyclohexanone thiosemicarbazones (III) in yields ranging from 40 to 50 percent. The compounds exhibited pronounced antiimplantation activity in female albino rats. 相似文献
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