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991.
992.
Kristin R. Pourian Sanford I. Finkel John S. Lyons 《The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions》1995,4(1):82-87
Medical records of 125 geropsychiatric inpatients were reviewed for a pilot study of the prevalence and medical and psychosocial correlates of chemical dependence and/or abuse. Patients were studied in three groups, each corresponding to the phased implementation of a program to enhance staff awareness of these problems. In contrast to patients without chemical dependence/abuse diagnoses, patients with these diagnoses had shorter lengths of stay, a greater number of psychiatric diagnoses, and were more likely to show personality disorder. Inception and implementation of the staff awareness program was associated with finding a significantly greater number of patients with chemical dependence/abuse diagnoses. 相似文献
993.
Pierluigi Tricoci L. Kristin Newby Robert M. Clare Sergio Leonardi C. Michael Gibson Robert P. Giugliano Paul W. Armstrong Frans Van de Werf Gilles Montalescot David J. Moliterno Claes Held Philip E. Aylward Lars Wallentin Robert A. Harrington Eugene Braunwald Kenneth W. Mahaffey Harvey D. White 《JACC: Cardiovascular Interventions》2018,11(9):856-864
Objectives
In 13,038 patients with non–ST-segment elevation acute coronary syndrome undergoing index percutaneous coronary intervention (PCI) in the EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Non–ST-Segment Elevation Acute Coronary Syndrome) and TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) trials, the relationship between PCI-related myocardial infarction (MI) and 1-year mortality was assessed.Background
The definition of PCI-related MI is controversial. The third universal definition of PCI-related MI requires cardiac troponin >5 times the 99th percentile of the normal reference limit from a stable or falling baseline and PCI-related clinical or angiographic complications. The definition from the Society for Cardiovascular Angiography and Interventions (SCAI) requires creatine kinase–MB elevation >10 times the upper limit of normal (or 5 times if new electrocardiographic Q waves are present). Implications of these definitions on prognosis, prevalence, and implementation are not established.Methods
In our cohort of patients undergoing PCI, PCI-related MIs were classified using the third universal type 4a MI definition and SCAI criteria. In the subgroup of patients included in the angiographic core laboratory (ACL) substudy of EARLY ACS (n = 1,401) local investigator– versus ACL-reported angiographic complications were compared.Results
Altogether, 2.0% of patients met third universal definition of PCI-related MI criteria, and 1.2% met SCAI criteria. One-year mortality was 3.3% with the third universal definition (hazard ratio: 1.96; 95% confidence interval: 1.24 to 3.10) and 5.3% with SCAI criteria (hazard ratio: 2.79; 95% confidence interval: 1.69 to 4.58; p < 0.001). Agreement between ACL and local investigators in detecting angiographic complications during PCI was overall moderate (κ = 0.53).Conclusions
The third universal definition of MI and the SCAI definition were both associated with significant risk for mortality at 1 year. Suboptimal concordance was observed between ACL and local investigators in identifying patients with PCI complications detected on angiography. (Trial to Assess the Effects of Vorapaxar [SCH 530348; MK-5348] in Preventing Heart Attack and Stroke in Participants With Acute Coronary Syndrome [TRA·CER] [Study P04736]; NCT00527943; EARLY ACS: Early Glycoprotein IIb/IIIa Inhibition in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome [Study P03684AM2]; NCT00089895) 相似文献994.
Wang EJ Pettoello-Mantovani M Anderson CM Osiecki K Moskowitz D Goldstein H 《The Journal of infectious diseases》2002,186(10):1412-1421
To develop a system in which transgenic and knockout technologies are used to study the in vivo behavior of human immunodeficiency virus type 1 (HIV-1) reservoirs, 2 different mouse models were combined: transgenic mice carrying full-length provirus encoding the monocyte-tropic HIV-1(JR-CSF) isolate (JR-CSF mice) and severe combined immunodeficient mice implanted with human fetal thymus and liver tissues (thy/liv-SCID-hu mice). Extensive HIV-1 infection of human thymic implants occurred after injection of JR-CSF mouse leukocytes into thy/liv-SCID-hu mice, indicating that these cells provide an in vivo source of replication-competent HIV-1. In vivo persistence of transferred JR-CSF mouse leukocytes carrying replication-competent HIV-1 in thy/liv-SCID-hu mice was indicated by the emergence of HIV-1 infection in mice that had no detectable HIV-1 infection until after highly active antiretroviral therapy. Thus, thy/liv-SCID-hu mice populated with JR-CSF mouse leukocytes, a persistent cellular reservoir harboring replication-competent HIV-1, present a new in vivo system for characterizing reservoirs of HIV-1 and evaluating therapeutic strategies designed to eliminate them. 相似文献
995.
Human embryonic-derived hematopoietic repopulating cells require distinct factors to sustain in vivo repopulating function 总被引:4,自引:0,他引:4
OBJECTIVE: We have previously identified a novel circulating embryonic blood cell capable of pluripotent hematopoietic reconstitution, which may serve as a target for in utero stem cell therapy. Based on its unique biological properties and ontogenic origin, we aim to examine the ability to maintain and retrovirally transduce fetal blood (FB) reconstituting cells in ex vivo culture conditions previously optimized for pluripotent hematopoietic repopulating cells derived from later stages of human ontogeny. METHODS: FB cells were evaluated for proliferative potential, progenitor composition, and SCID-repopulating cell (SRC) capacity before and after 3 days of serum free (SF) ex vivo culture using the previously optimized growth factor conditions of SCF, Flt-3L, IL-3, IL-6, and G-CSF (GF Mix), in comparison to cultures using GF Mix + oncostatin M (OSM), or SCF + Flt-3L. We further examined the ability to retrovirally transduce FB-SRC maintained in culture using SCF + Flt-3L alone. RESULTS: Circulating FB-SRC could not be maintained under GF Mix conditions previously shown to sustain CB (cord blood)-SRC. Ex vivo culture with SCF + Flt-3L reduced the proliferation of primitive FB cells lacking lineage commitment markers (Lin(-)), but expanded FB progenitors and sustained FB-SRC compared to culture with GF Mix with and without OSM. Using SCF + Flt-3L, FB-SRC capable of multilineage reconstitution were successfully transduced, suggesting that SCF and Flt-3L are necessary and sufficient for the survival and transduction of human hematopoietic repopulating cells of embryonic origin. CONCLUSION: Our study provides novel insights into the requirements of primitive FB reconstituting cells that are essential for developing in utero stem cell gene therapy protocols, and further illustrates the biological distinctiveness of FB-SRC compared to hematopoietic repopulating cells from other stages of human ontogeny. 相似文献
996.
Johannesdottir F Aspelund T Siggeirsdottir K Jonsson BY Mogensen B Sigurdsson S Harris TB Gudnason VG Lang TF Sigurdsson G 《Calcified tissue international》2012,90(5):354-364
In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people
using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association
of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924
women), aged 66–96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area
and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical
area and total shaft area (adjusted for age, height, and weight) but explained <10 % of variability in those bone parameters.
The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association
between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained
incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high
BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different
rates and with different gender patterns. 相似文献
997.
998.
The technique of autologous fat transplantation has been dramatically improved since its first introduction in 1893. This surgical approach has more recently been used in both the reconstructive and cosmetic setting, and has subsequently been the subject of much controversy. We sought to compose a detailed and systematic literature review of recent literature on the topic in order to provide surgeons with the data in an organized and easily accessible manner. We selected 19 studies and systematically documented trends in their methods, follow-up procedures, and outcomes, paying particular attention to complications. We chose to include studies that analyzed the outcomes of the surgical procedure in both reconstructive and cosmetic cases. Most authors reported satisfactory or greater results, and we concluded that it appears as though autologous fat transplantation to the breast is a safe option for patients seeking both reconstructive and cosmetic surgery. 相似文献
999.
1000.
Shih AW Weir MA Clemens KK Yao Z Gomes T Mamdani MM Juurlink DN Hird A Hodsman A Parikh CR Wald R Cadarette SM Garg AX 《Kidney international》2012,82(8):903-908
Intravenous bisphosphonates can cause acute kidney injury; however, this risk was not found with oral bisphosphonates in randomized clinical trials with restrictive eligibility criteria. In order to provide complementary safety data, we studied the risk of acute kidney injury in a population-based cohort of 122,727 patients aged 66 years and older discharged from hospital following a new fragility fracture and no history of bisphosphonate use in the prior year. Bisphosphonate treatment was identified within 120 days after discharge and event rates were measured from 90 days of therapy initiation. The primary outcome was hospitalization with acute kidney injury with secondary outcomes of new nephrology consultation and, in a subset of patients with laboratory values, acute kidney injury was defined as an increase in serum creatinine. We identified 18,286 bisphosphonate users and 104,441 non-users with a mean age of 81 years. Of 5772 patients with laboratory values, 40% had chronic kidney disease (eGFR <60?ml/min per 1.73?m(2)). Overall, there was no statistically significant difference in the risk of acute kidney injury among bisphosphonate users compared to non-users (adjusted odds ratio 1.03), and no significant differences in other outcomes or in subgroups of patients with baseline chronic kidney disease. Thus, in this older population-based cohort, oral bisphosphonate use was not associated with acute kidney injury. 相似文献