碘伏清洗外耳道的效果观察

目的 探讨碘伏清洗外耳道的效果。方法 将耳部疾病患者100例（127耳）随机分为观察组和对照组各50例，观察组采用0．5％碘伏液清洗外耳道，对照组采用3％过氧化氩液清洗外耳道。两组其他操作方法相同。结果 两组治疗效果比较，差异无显著性意义（P〉0．05），但观察组外耳道清洗后耳痛发生率显著低于对照组（P〈0．01）。结论 0．5％碘伏液清洗外耳疗效较好，对皮肤黏膜无刺激，可减轻患者痛苦，是比较满意的外耳道洗耳液。     

A prospective study of the association of cerebrospinal fluid monoamine metabolite levels with lethality of suicide attempts in patients with bipolar disorder

Objectives:  Bipolar disorder is a severe illness that is associated with suicidal behavior. A biological predictor of highly lethal suicide attempts in patients with bipolar disorder would be valuable. We hypothesized that cerebrospinal fluid (CSF) monoamine metabolite levels are related to lethality of suicide attempts in bipolar patients and examined the relation between CSF 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and maximum lethality of suicide attempts at baseline and during a 2-year follow up.
Methods:  Twenty-seven bipolar depressed patients participated in the study. Demographic and clinical parameters were examined and recorded. Lumbar punctures were performed and CSF 5-HIAA, HVA, and MHPG were assayed by high-performance liquid chromatography with electrochemical detection. Following discharge, patients were evaluated after 3 months, 1 year, and 2 years. Each follow-up interview included an in-depth assessment of suicidal behavior during the intervening time period.
Results:  Six subjects made suicide attempts during the 2-year follow-up. Bipolar patients who attempted suicide during the follow-up period had higher aggression and hostility scale scores compared to bipolar subjects who did not make a suicide attempt during the follow-up period. CSF 5-HIAA, HVA, and MHPG levels were negatively correlated with the maximum lethality of suicide attempts during the 2-year follow-up period.
Conclusions:  Our finding is the first observation that CSF monoamine metabolite levels may be predictors of lethality of suicide attempts in patients with bipolar disorder. Further studies are necessary to answer the question whether CSF monoamine metabolite levels are clinically useful biochemical predictors of highly lethal suicide attempts or completed suicides.     

准分子激光屈光性角膜切削术治疗近视及近视散光临床分析

目的评价准分子激光屈光性角膜切削术治疗近视及近视散光的临床效果。方法应用准分子激光（NIDEKEC—5000型）治疗24D以下．伴或不件5D以内散光的近视眼。214只治疗眼随诊6个月以上。结果随诊1年以上的病例显示术后3个月屈光度及视力基本稳定。术后6个月时，在等值球镜度低于6D的治疗眼中，裸眼视力≥1．0者占92．04％，≥0．5为100％，80．53％的裸眼视力≥术前最佳矫正视力，99．12％的眼屈光度在预定矫正度数的±1．00D以内。低于10D的高度近视眼也有近似的疗效。214只治疗眼中操眼视力≥1．0者占78．97％，≥0．5为90．65％，72．43％的裸眼视力≥术前最佳矫正视力，88．32％的眼屈光度在预定矫正度数的±1．00D以内。6只眼（2．80％）最佳矫正视力减少2行以上，有Ⅱ级以上Haze的有7眼间（3．27％）。结论准分子激光屈光性角膜切削术治疗近视及近视散光具有很高程度的精确性和安全性，在＜10D的近视眼中更显示了良好的预测性和稳定性。     

催化分光光度法测定人发中微量铁

拟定了一简单实用的测定人发中铁的催化分光光度法。在实验条件下,人发中常见的数10种微量元素均不干扰铁的测定,回收率达86～106%。     

超细α-FeOOH制备过程研究 Ⅰ.制备工艺

以制备晶形、粒度、轴比等满足高性能磁粉要求的铁黄为目标,研究了碱法超细α-FeOOH合成的工艺配方和工艺条件对粒子性能的影响,包括碱比、气量、转速、Fe(OH)_2结晶条件、熟化时间等工艺参数的影响规律。重复稳定地制备出三类超微粒α-FeOOH粒子,其粒度分别为0.18、0.28、0.39μm,分布均匀,无枝叉。     

预防性应用钙拮抗剂对缺血大鼠心肌细胞和红细胞内钙变化的影响

利用大鼠缺血模型观察预防性应用钙桔抗剂尼莫地平对大鼠缺血心肌和红细胞内钙的影响发现，缺血时大鼠心肌细胞、心肌组织和红细胞内均有钙积聚，红细胞膜钙泵活性下降；缺血前30分钟给予尼莫地平可使红细胞内钙恢复至正常水平，红细胞膜钙泵活性升高；心肌细胞和心肌组织内钙虽较缺血鼠降低，但仍高于对照组。提示：（1）缺血时细胞的钙内流可能是全身性的；（2）预防性应用尼莫地平可阻滞或减轻细胞内钙超载，同时还可保护细胞膜膜泵活性。     

Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

The present work tries to establish the antioxidant capacity of the peripheral nervous tissue of the rat, in terms of the enzymatic activities present in this tissue that either prevent the formation of activated species as the semiquinone radical (DT-diaphorase), protect against activated oxygen species (superoxide dismutase, glutathione peroxidase), conjugate natural toxic products or xenobiotics (glutathione S-transferases, especially the activity conjugating 4-hydroxy-nonenal), or complete the glutathione system metabolism (glutathione disulfide reductase, γ-glutamyl transpeptidase). All the activities studied are lower in this tissue than they are in liver, except for γ-glutamyl transpeptidase. The relevance of the results obtained and its possible relationship with different neuropathies is discussed. It is concluded that the peripheral nervous tissue is by far less protected than the liver against oxidative damage.     

Melatonin reduces nitric oxide synthase activity in rat hypothalamus

Abstract: In this report, rat hypothalamic nitric oxide synthase (NOS) activity is shown to be partially inhibited by physiological concentrations of the pineal hormone melatonin. In vitro studies demonstrate that 1 nM melatonin, which approximates the physiological concentration of the hormone at night, significantly inhibited NOS activity. In vivo studies show that administering melatonin or collecting the hypothalamus from animals at night, when endogenous melatonin levels are elevated, results in a significant decrease of NOS activity. Results also show that calmodulin may be involved in this process since its presence in the incubation medium prevents the inhibitory effect of melatonin on NOS activity.