全文获取类型
收费全文 | 2953篇 |
免费 | 114篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 79篇 |
妇产科学 | 25篇 |
基础医学 | 369篇 |
口腔科学 | 94篇 |
临床医学 | 193篇 |
内科学 | 875篇 |
皮肤病学 | 46篇 |
神经病学 | 205篇 |
特种医学 | 99篇 |
外科学 | 486篇 |
综合类 | 4篇 |
预防医学 | 106篇 |
眼科学 | 53篇 |
药学 | 162篇 |
中国医学 | 1篇 |
肿瘤学 | 284篇 |
出版年
2023年 | 9篇 |
2022年 | 40篇 |
2021年 | 71篇 |
2020年 | 32篇 |
2019年 | 50篇 |
2018年 | 66篇 |
2017年 | 40篇 |
2016年 | 52篇 |
2015年 | 62篇 |
2014年 | 76篇 |
2013年 | 108篇 |
2012年 | 166篇 |
2011年 | 185篇 |
2010年 | 104篇 |
2009年 | 98篇 |
2008年 | 158篇 |
2007年 | 199篇 |
2006年 | 190篇 |
2005年 | 195篇 |
2004年 | 144篇 |
2003年 | 175篇 |
2002年 | 167篇 |
2001年 | 33篇 |
2000年 | 28篇 |
1999年 | 37篇 |
1998年 | 55篇 |
1997年 | 34篇 |
1996年 | 37篇 |
1995年 | 32篇 |
1994年 | 34篇 |
1993年 | 23篇 |
1992年 | 41篇 |
1991年 | 35篇 |
1990年 | 28篇 |
1989年 | 25篇 |
1988年 | 24篇 |
1987年 | 28篇 |
1986年 | 27篇 |
1985年 | 15篇 |
1984年 | 24篇 |
1983年 | 17篇 |
1982年 | 26篇 |
1981年 | 11篇 |
1979年 | 11篇 |
1978年 | 6篇 |
1977年 | 12篇 |
1974年 | 6篇 |
1972年 | 5篇 |
1966年 | 5篇 |
1962年 | 4篇 |
排序方式: 共有3093条查询结果,搜索用时 15 毫秒
51.
52.
Michal Stein Shelly Lipman-Arens Kfir Oved Asi Cohen Ellen Bamberger Roy Navon Olga Boico Tom Friedman Liat Etshtein Meital Paz Tanya M. Gottlieb Or Kriger Yura Fonar Ester Pri-Or Renata Yacobov Yaniv Dotan Amit Hochberg Moti Grupper Adi Klein 《Diagnostic microbiology and infectious disease》2018,90(3):206-213
Bacterial and viral lower respiratory tract infections (LRTIs) are often clinically indistinguishable, leading to antibiotic overuse. We compared the diagnostic accuracy of a new assay that combines 3 host-biomarkers (TRAIL, IP-10, CRP) with parameters in routine use to distinguish bacterial from viral LRTIs. Study cohort included 184 potentially eligible pediatric and adult patients. Reference standard diagnosis was based on adjudication by an expert panel following comprehensive clinical and laboratory investigation (including respiratory PCRs). Experts were blinded to assay results and assay performers were blinded to reference standard outcomes. Evaluated cohort included 88 bacterial and 36 viral patients (23 did not fulfill inclusion criteria; 37 had indeterminate reference standard outcome). Assay distinguished bacterial from viral LRTI patients with sensitivity of 0.93 ± 0.06 and specificity of 0.91 ± 0.09, outperforming routine parameters, including WBC, CRP and chest x-ray signs. These findings support the assay's potential to help clinicians avoid missing bacterial LRTIs or overusing antibiotics. 相似文献
53.
Junya Sakamoto Yoshitaka Manabe Joichi Oyamada Hideki Kataoka Jiro Nakano Kazunobu Saiki Keishi Okamoto Toshiyuki Tsurumoto Minoru Okita 《Clinical anatomy (New York, N.Y.)》2018,31(5):705-709
Introduction : Referred pain in the anterior knee joint is the most common symptom in hip disease patients. The development of referred pain is considered to be related to dichotomizing peripheral sensory fibers. However, no gross anatomical findings identify any dichotomizing fibers innervating both the hip and knee joints. We dissected the femoral and obturator nerves in human cadavers to investigate the distribution of the articular branches in the hip and knee joints. Fourteen embalmed left lower limbs from 14 Japanese adult cadavers (five from females, nine from males, average age 73.8 ± 14.1 years) were observed macroscopically. The articular branches of the femoral and obturator nerves were dissected at the anterior margin of the groin toward the thigh region. After dissections of the articular nerves of the hip joints, the femoral and obturator nerves were exposed from proximally to distally to identify the articular nerves of the knee joints. The branching pattern of the articular branches in the hip and knee joints was recorded. In six of 14 limbs (42.9%), the femoral nerve supplied articular branches to the anteromedial aspect of both the hip and knee joints. These articular branches were derived from the same bundle of femoral nerve. These gross anatomical findings suggested that dichotomizing peripheral sensory fibers innervate the hip and knee joints and these could relate to the referred pain confirmed in the anterior knee joints of patients with hip disease. Clin. Anat. 31:705–709, 2018. © 2018 Wiley Periodicals, Inc. 相似文献
54.
55.
Shinichiro Muro Hironari Kato Etsuji Ishida Toru Ueki Masakuni Fujii Ryo Harada Hiroyuki Seki Ken Hirao Masaki Wato Yutaka Akimoto Masahiro Takatani Hirofumi Tsugeno Jiro Miyaike Tatsuya Toyokawa Mamoru Nishimura Naoko Yunoki Hiroyuki Okada 《Journal of gastroenterology and hepatology》2020,35(1):37-42
56.
57.
Hypophosphatasia (HPP) is an inherited skeletal disease with features of hypomineralization of bone and early exfoliation of primary teeth due to disturbed cementum formation. Recent introduction of enzyme replacement therapy has reduced mortality in severe cases, though the effects of that treatment on dental manifestations remain unknown. We examined an avulsed primary incisor in a 3-year-old female diagnosed with perinatal HPP who underwent enzyme replacement therapy from 1 day after birth and report our findings. 相似文献
58.
Evaluation of duodenal hypersensitivity induced by duodenal acidification using transnasal endoscopy
Manabu Ishii Hiroaki Kusunoki Noriaki Manabe Tomoari Kamada Motonori Sato Hiroshi Imamura Akiko Shiotani Jiro Hata Ken Haruma 《Journal of gastroenterology and hepatology》2010,25(5):913-918
Background and Aim: Although duodenal hypersensitivity has been suggested as one of the causes of functional dyspepsia (FD), a practical method to clarify this has not yet been established. The aim of this study was to evaluate whether patients with FD have duodenal hypersensitivity to acid, using transnasal endoscopy. Methods: In all, 44 patients with FD and 16 healthy volunteers were enrolled, and all the subjects received transnasal endoscopy in the morning after overnight fasting. After ordinary transnasal endoscopy, an infusion tube was introduced into the duodenal bulb by transnasal endoscopy and acid (20 mL, 0.1 N HCl, 20 mL/min, 36.5°C) was injected via the infusion tube. The severity of 12 symptoms was assessed by each subject using a 100‐mm visual analogue scale. The maximum severity scale was defined as the maximum score of the symptom severity scale. The total score was defined as the aggregate score of the maximum severity scale of the 12 symptoms. The maximum severity scales and the total scores between patients with FD and healthy volunteers were evaluated. Results: The maximum severity scales of nine symptoms increased significantly more after acid infusion in patients with FD than in healthy volunteers (P < 0.05). There were significant differences in the total scores (patients with FD vs healthy volunteers 233.8 ± 37.8 vs 63.9 ± 14.6, mean ± standard error of the mean, P < 0.001). Conclusions: Duodenal acidification using transnasal endoscopy enabled the evaluation of duodenal hypersensitivity to acid in healthy volunteers and patients with FD. 相似文献
59.
New therapeutic approach for impaired arteriogenesis in diabetic mouse hindlimb ischemia. 总被引:1,自引:0,他引:1
Shyamal Chandra Bir Masatoshi Fujita Akira Marui Keiichi Hirose Yoshio Arai Hisashi Sakaguchi Yuhong Huang Jiro Esaki Tadashi Ikeda Yasuhiko Tabata Masashi Komeda 《Circulation journal》2008,72(4):633-640
BACKGROUND: The combined treatment of sustained-release basic fibroblast growth factor (Sr-bFGF) and a 5-hydroxytryptamine(2A) blocker, sarpogrelate, was evaluated to see whether it reversed the impaired collateral circulation in diabetic (DM) mouse hindlimb ischemia. METHOD AND RESULTS: Diabetic and normal mice with ischemic hindlimb were randomly assigned to 1 of 5 experimental groups (no treatment, sarpogrelate 50 mg . kg(-1) . day(-1), 20 microg or 50 microg Sr-bFGF and a combined treatment of 20 microg Sr-bFGF and sarpogrelate), and treated for 4 weeks. Tissue blood perfusion (TBP), vascular density (angiogenesis) and the number of mature vessels (arteriogenesis) were checked by the use of standard methods. Although angiogenesis was comparable (161+/-14 vs 154+/-12 vessels/mm(2)), the laser Doppler perfusion image index (LDPII) (0.43+/-0.11 (SD) vs 0.63+/-0.08, p<0.05) and arteriogenesis (8+/-3 vs 12+/-4 vessels/mm(2), p<0.05) were significantly lower in DM mice than those in normal mice. The dose of Sr-bFGF for the sufficient number of mature vessels (>or=45 vessels/mm(2)) and LDPII (>or=0.9) was 20 microg for the normal mice, and 50 microg for the DM mice, which was reduced with the aid of sarpogrelate. Conclusions A combined therapy of Sr-bFGF and sarpogrelate is effective for neovascularization to reverse the impaired arteriogenesis and TBP in DM mice. 相似文献