全文获取类型
收费全文 | 7177篇 |
免费 | 280篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 156篇 |
妇产科学 | 141篇 |
基础医学 | 861篇 |
口腔科学 | 130篇 |
临床医学 | 538篇 |
内科学 | 2008篇 |
皮肤病学 | 87篇 |
神经病学 | 526篇 |
特种医学 | 428篇 |
外科学 | 1211篇 |
综合类 | 18篇 |
预防医学 | 187篇 |
眼科学 | 67篇 |
药学 | 470篇 |
中国医学 | 6篇 |
肿瘤学 | 653篇 |
出版年
2023年 | 33篇 |
2022年 | 87篇 |
2021年 | 145篇 |
2020年 | 83篇 |
2019年 | 115篇 |
2018年 | 129篇 |
2017年 | 96篇 |
2016年 | 128篇 |
2015年 | 127篇 |
2014年 | 180篇 |
2013年 | 211篇 |
2012年 | 334篇 |
2011年 | 421篇 |
2010年 | 240篇 |
2009年 | 198篇 |
2008年 | 318篇 |
2007年 | 387篇 |
2006年 | 362篇 |
2005年 | 366篇 |
2004年 | 358篇 |
2003年 | 353篇 |
2002年 | 336篇 |
2001年 | 196篇 |
2000年 | 196篇 |
1999年 | 188篇 |
1998年 | 96篇 |
1997年 | 89篇 |
1996年 | 62篇 |
1995年 | 49篇 |
1994年 | 53篇 |
1993年 | 42篇 |
1992年 | 120篇 |
1991年 | 126篇 |
1990年 | 129篇 |
1989年 | 98篇 |
1988年 | 96篇 |
1987年 | 96篇 |
1986年 | 100篇 |
1985年 | 82篇 |
1984年 | 75篇 |
1983年 | 59篇 |
1982年 | 43篇 |
1979年 | 37篇 |
1978年 | 35篇 |
1977年 | 38篇 |
1975年 | 33篇 |
1974年 | 39篇 |
1972年 | 44篇 |
1971年 | 37篇 |
1968年 | 33篇 |
排序方式: 共有7522条查询结果,搜索用时 46 毫秒
91.
K Ito T Ogita M Suko M Mori K Kudo T Hayakawa H Okudaira Y Horiuchi 《International archives of allergy and applied immunology》1979,58(4):474-476
IgE levels in nude mice were estimated by the one-step single radial radiodiffusion method antisera prepared by immunization of guinea pigs with an IgE-rich fraction obtained from sera of normal mice infected with Nippostrongylus brasiliensis and immunized with DNP-ovalbumin in alum gel. 3 out of 8 nude mice had IgE levels significantly higher than those of normal mice. 相似文献
92.
Absence of either gastric or intestinal phenotype in microscopic differentiated gastric carcinomas 总被引:6,自引:0,他引:6
Kawachi H Takizawa T Eishi Y Shimizu S Kumagai J Funata N Koike M 《The Journal of pathology》2003,199(4):436-446
Differentiated gastric carcinoma (DGC) corresponds roughly to the intestinal type of gastric carcinoma described by Laurén. It has been suggested that DGCs arise from intestinalized gastric mucosa, but recent findings regarding their mucin expression do not support this hypothesis. To evaluate the histogenetic relationship between DGCs and intestinal metaplasia, lesions that are as small as possible should be examined. Twenty-five DGCs, ranging in their greatest dimension from 0.4 to 2.7 mm, were collected and divided into two groups by size. Group A consisted of 13 lesions less than 1.4 mm across, and group B of 12 lesions 1.4 mm or more. The presence of mucin and a brush border was assessed by immunostaining with antibodies against human gastric mucin, pyloric-gland-type mucin, Muc-2 glycoprotein, and CD10 antigen, and the lesions were classified as having the gastric phenotype (G-type), intestinal phenotype (I-type), mixed gastric and intestinal phenotype (M-type), or null phenotype (N-type). Thirteen (52%) of the 25 lesions were N-type, 5 (20%) lesions were G-type, 5 (20%) were I-type, and 2 (8%) were M-type. Group A had a larger proportion of N-type lesions than B (10/13, or 77%, vs. 3/12, or 25%; p = 0.027, chi-square test for proportions). Group B had a larger proportion of G-type lesions than A (5/12, or 42%, vs. 0/13, or 0%; p = 0.033). The phenotypes of the carcinomas and their surrounding mucosa were unrelated. Therefore, DGCs may arise from gastric mucosa affected by intestinal metaplasia or not, without having either the gastric or intestinal phenotype. 相似文献
93.
Nishida Hayato Fukuhara Hiroki Nawano Takaaki Kanno Hidenori Yagi Mayu Yamagishi Atsushi Sakurai Toshihiko Naito Sei Kato Tomoyuki Kudo Kosuke Ichikawa Kazunobu Tsuchiya Norihiko 《Clinical and experimental nephrology》2021,25(12):1346-1353
Clinical and Experimental Nephrology - Arteriovenous fistula (AVF) is the most preferred vascular access for hemodialysis patients, and early failure of AVF is one of the most avoidable... 相似文献
94.
Takuma Narita Shingo Hatakeyama Shintaro Narita Masahiro Takahashi Toshihiko Sakurai Sadafumi Kawamura Senji Hoshi Jiro Shimoda Toshiaki Kawaguchi Shigeto Ishidoya Koji Mitsuzuka Yoichi Arai Akihiro Ito Norihiko Tsuchiya Tomonori Habuchi Chikara Ohyama 《Translational andrology and urology》2021,10(1):417
BackgroundThe clinical benefit of the combined androgen blockade (CAB) therapy over luteinizing hormone-releasing hormone analog (LH-RHa) monotherapy for hormone naïve metastatic prostate cancer (mHNPC) is unclear. Therefore, we retrospectively compare the effectiveness of CAB with the LH-RHa monotherapy on the prognosis of Japanese patients with mHNPC.MethodsWe retrospectively evaluated the prognosis of 517 patients diagnosed with mHNPC between August 2001 and May 2017. The patients’ data were obtained from the Michinoku Urological Cancer Research Group database and Hirosaki University-related hospitals. Patients were divided into the CAB and LH-RHa monotherapy groups based on primary androgen deprivation therapy (ADT). Overall survival (OS), cancer-specific survival (CSS), and castrate-resistant prostate cancer-free survival (CRPC-FS) were compared between the two groups using the Kaplan-Meier curve analysis. Inverse probability of treatment weighting (IPTW)-adjusted Cox hazard proportional analyses was performed to investigate the effect of primary ADT on oncological outcomes.ResultsThe median age was 73 years old. The numbers of patients in the CAB and LH-RHa monotherapy groups were 447 and 70, respectively. The Kaplan-Meier curve analysis showed no significant differences in either 5-year OS (56.7% vs. 52.5%, P=0.277), CSS (61.1% vs. 56.4%, P=0.400), and CRPC-FS (33.1% vs. 31.1%, P=0.529) between the groups. IPTW-adjusted multivariate Cox hazard proportional analyses showed no significant differences in OS, CSS, and CRPC-FS between the two groups.ConclusionsNo significant differences in oncological outcomes were observed between the CAB and LH-RHa monotherapy groups in patients with mHNPC. 相似文献
95.
96.
97.
98.
99.
100.
Yoshikuni Kudo Toru Egashira Fusako Takayama Yasumitsu Yamanaka Tatsuo Shimada 《Archives of toxicology》1993,67(7):502-509
To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the liver tissue increased significantly. Electron microscopic studies revealed that most of the hepatocytes had swollen mitochondria and clumping of the nuclear chromatin. The sinusoidal endothelium was disrupted and the sinusoidal lumen was filled with numerous erythrocytes. Blood endotoxin concentration, plasma lipid peroxide levels, and serum -glucuronidase activities were significantly higher than in the control group. Biochemical and morphological renal injury was also observed. Tissue lipid peroxide levels increased in both the kidney and the liver. Microscopic examination revealed damage to the renal tubules, including interstitial edema, dilatation of the lumen, and granular casts derived from necrotic cells in the proximal convoluted tubule. The levels of urinary N-acetyl--d-glucosaminidase (NAG) in the liver ischemia-reperfusion group were also higher than in the control group. These results suggest that the renal injury was caused by an increase in endotoxin, lipid peroxide, and lysosomal enzymes in the blood following the liver injury induced by the ischemia-reperfusion. 相似文献