全文获取类型
收费全文 | 6586篇 |
免费 | 326篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 168篇 |
妇产科学 | 142篇 |
基础医学 | 745篇 |
口腔科学 | 298篇 |
临床医学 | 458篇 |
内科学 | 1435篇 |
皮肤病学 | 197篇 |
神经病学 | 606篇 |
特种医学 | 122篇 |
外科学 | 1074篇 |
综合类 | 34篇 |
一般理论 | 1篇 |
预防医学 | 601篇 |
眼科学 | 197篇 |
药学 | 334篇 |
中国医学 | 56篇 |
肿瘤学 | 390篇 |
出版年
2023年 | 43篇 |
2022年 | 81篇 |
2021年 | 230篇 |
2020年 | 122篇 |
2019年 | 174篇 |
2018年 | 225篇 |
2017年 | 129篇 |
2016年 | 152篇 |
2015年 | 172篇 |
2014年 | 259篇 |
2013年 | 303篇 |
2012年 | 547篇 |
2011年 | 522篇 |
2010年 | 304篇 |
2009年 | 279篇 |
2008年 | 459篇 |
2007年 | 507篇 |
2006年 | 414篇 |
2005年 | 425篇 |
2004年 | 373篇 |
2003年 | 342篇 |
2002年 | 338篇 |
2001年 | 44篇 |
2000年 | 29篇 |
1999年 | 41篇 |
1998年 | 45篇 |
1997年 | 30篇 |
1996年 | 31篇 |
1995年 | 27篇 |
1994年 | 16篇 |
1993年 | 21篇 |
1992年 | 13篇 |
1991年 | 12篇 |
1990年 | 12篇 |
1989年 | 17篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 10篇 |
1984年 | 12篇 |
1983年 | 12篇 |
1982年 | 18篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1979年 | 15篇 |
1978年 | 10篇 |
1977年 | 9篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1974年 | 5篇 |
排序方式: 共有6935条查询结果,搜索用时 15 毫秒
991.
992.
Mínguez-Alarcón L Mendiola J López-Espín JJ Sarabia-Cos L Vivero-Salmerón G Vioque J Navarrete-Muñoz EM Torres-Cantero AM 《Human reproduction (Oxford, England)》2012,27(9):2807-2814
STUDY QUESTION What are the associations between the dietary intake of antioxidant nutrients and semen parameters in young men? SUMMARY ANSWER Our study suggests that some sperm parameters are sensitive to dietary intake of antioxidant nutrients. WHAT IS KNOWN ALREADY A few reports have suggested that some dietary factors might be related to semen quality. However, the relationship between the intake of antioxidant nutrients and semen quality in young men remains unexplored. STUDY DESIGN, SIZE, DURATION In this cross-sectional study, 215 young men were included between October 2010 and November 2011. PARTICIPANTS/MATERIALS, SETTING, METHODS Healthy university students with complete dietary and semen quality data were analyzed. Dietary intake was recorded using a validated food frequency questionnaire. The associations between the energy-adjusted nutrient intake of antioxidants in quartiles and the semen volume, sperm concentration, sperm motility, sperm morphology, total sperm count and total motile sperm count were assessed using multivariate linear regression. MAIN RESULTS AND THE ROLE OF CHANCE Out of 240 students who contacted us, 223 (92.9%) were eligible to participate in this study, and 215 attended the clinical appointment. In the multivariate adjusted linear regression models, there was a positive association between dietary intakes of cryptoxanthin (P(trend) = 0.03), vitamin C (P(trend) = 0.04), lycopene (P(trend) = 0.03) and β-carotene (P(trend) = 0.04) and total motile sperm count. The semen volume increased with higher intakes of vitamin C (P(trend) = 0.04). LIMITATIONS, REASONS FOR CAUTION Only one sample of semen was taken for each subject. However, there are indications that one semen sample may be sufficient to characterize the semen quality of the individuals in epidemiological studies. Bias due to measurement errors may also occur since there is no perfect method to assess diet. However, any bias due to measurement error would be non-differential and would reduce, not increase, the strength of the associations. Although selection bias in cross-sectional studies might not always be ruled out, our subjects were university student volunteers who were rewarded for their participation and the study was not advertised as a fertility study. WIDER IMPLICATIONS OF THE FINDINGS Previous articles in this area have focused mainly on men attending fertility clinics, thus our study brings generalizability to young men of the general population with unknown or untested fertility. Some of our results are in agreement with the previously reported papers. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by 'Fundación Séneca, Región de Murcia, Agencia Regional de Ciencia y Tecnología, grant number: 08808/PI/08', and 'Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (FIS) grant number: PI10/00985'. The authors have no competing interests to declare. 相似文献
993.
Ventim R Ramos JA Osório H Lopes RJ Pérez-Tris J Mendes L 《Parasitology research》2012,111(2):637-645
In the complex life cycle of avian malaria parasites (Plasmodium sp.), we still have a poor understanding on the vector-parasite relationships. This study described the community of potential avian malaria vectors in four Portuguese reedbeds. We tested if their geographical distribution differed, and investigated on their Plasmodium infections. The mosquitoes' feeding preferences were evaluated using CO(2), mice, and birds as baits. The most abundant species were Culex pipiens, Culex theileri, and Ochlerotatus caspius (and, in one site, Coquillettidia richiardii). Plasmodium lineages SGS1 and SYAT05 were found in unengorged Cx. pipiens and Cx. theileri, respectively, suggesting that these mosquitoes were competent vectors of those lineages. The species' abundance was significantly different among sites, which may help to explain the observed differences in the prevalence of SGS1. At the study sites, SGS1 was detected in the most abundant mosquito species and reached a high prevalence in the most abundant passerine species. Probably, this parasite needs abundant hosts in all phases of its cycle to keep a good reservoir of infection in all its stages. Cq. richiardii showed an opportunistic feeding behavior, while Cx. pipiens appeared to be more mammophilic than previously described, perhaps because the used avian bait was not its preferential target. In one of the study sites, mosquitoes seem to be attracted to the Spotless Starling Sturnus unicolor, an abundant bird species that may be an important local reservoir of avian malaria infections. To our knowledge, this is the first report of detection of avian Plasmodium DNA from European mosquitoes. 相似文献
994.
Objective
Evaluate the effect of changes in the water disinfection process, and presence of lead service lines (LSLs), on children’s blood lead levels (BLLs) in Washington, DC.Methods
Three cross-sectional analyses examined the relationship of LSL and changes in water disinfectant with BLLs in children <6 years of age. The study population was derived from the DC Childhood Lead Poisoning Prevention Program blood lead surveillance system of children who were tested and whose blood lead test results were reported to the DC Health Department. The Washington, DC Water and Sewer Authority (WASA) provided information on LSLs. The final study population consisted of 63,854 children with validated addresses.Results
Controlling for age of housing, LSL was an independent risk factor for BLLs ≥10 μg/dL, and ≥5 μg/dL even during time periods when water levels met the US Environmental Protection Agency (EPA) action level of 15 parts per billion (ppb). When chloramine alone was used to disinfect water, the risk for BLL in the highest quartile among children in homes with LSL was greater than when either chlorine or chloramine with orthophosphate was used. For children tested after LSLs in their houses were replaced, those with partially replaced LSL were >3 times as likely to have BLLs ≥10 μg/dL versus children who never had LSLs.Conclusions
LSLs were a risk factor for elevated BLLs even when WASA met the EPA water action level. Changes in water disinfection can enhance the effect of LSLs and increase lead exposure. Partially replacing LSLs may not decrease the risk of elevated BLLs associated with LSL exposure. 相似文献995.
996.
997.
Puett RC Hart JE Schwartz J Hu FB Liese AD Laden F 《Environmental health perspectives》2011,119(3):384-389
Background
Although studies have found that diabetes mellitus (DM) modifies the impact of exposures from air pollution on cardiovascular outcomes, information is limited regarding DM as an air pollution-associated outcome.Objectives
Using two prospective cohorts, the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS), we investigated the relationship of incident type 2 DM with exposures to particulate matter (PM) <2.5 μm (PM2.5), PM <10 μm (PM10), and PM between 2.5 and 10 μm in aerodynamic diameter (PM10–2.5) in the previous 12 months and the distance to roadways.Methods
Cases were reported and confirmed through biennial and supplemental questionnaires of diagnosis and treatment information. During follow-up from 1989 to 2002, questionnaires provided information on time-varying covariates and updated addresses. Addresses were geocoded and used to assign air pollution exposures from spatiotemporal statistical models.Results
Among participants living in metropolitan areas of the northeastern and midwestern United States, there were 3,784 incident cases of DM in the NHS, and 688 cases in the HPFS. Pooled results from random effects meta-analysis of cohort-specific models adjusted for body mass index and other known risk factors produced hazard ratios (HRs) for incident DM with interquartile range (IQR) increases in average PM during the 12 months before diagnosis of 1.03 [95% confidence interval (CI), 0.96–1.10] for PM2.5, 1.04 (95% CI, 0.99–1.09) for PM10, and 1.04 (95% CI, 0.99–1.09) for PM10–2.5. Among women, the fully adjusted HR for living < 50 m versus ≥ 200 m from a roadway was 1.14 (95% CI, 1.03–1.27).Conclusions
Overall, results did not provide strong evidence of an association between exposure to PM in the previous 12 months and incident DM; however, an association with distance to road (a proxy marker of exposure to traffic-related pollution) was shown among women. 相似文献998.
Madrigano J Baccarelli A Mittleman MA Wright RO Sparrow D Vokonas PS Tarantini L Schwartz J 《Environmental health perspectives》2011,119(7):977-982
Background: DNA methylation is a potential pathway linking environmental exposures to disease. Exposure to particulate air pollution has been associated with increased cardiovascular morbidity and mortality, and lower blood DNA methylation has been found in processes related to cardiovascular morbidity.Objective: We hypothesized that prolonged exposure to particulate pollution would be associated with hypomethylation of repetitive DNA elements and that this association would be modified by genes involved in glutathione metabolism and other host characteristics.Methods: DNA methylation of the long interspersed nucleotide element–1 (LINE-1) and the short interspersed nucleotide element Alu were measured by quantitative polymerase chain reaction pyrosequencing in 1,406 blood samples from 706 elderly participants in the Normative Aging Study. We estimated changes in repetitive element DNA methylation associated with ambient particles (particulate matter ≤ 2.5 µm in aerodynamic diameter), black carbon (BC), and sulfates (SO4), with mixed models. We examined multiple exposure windows (1–6 months) before DNA methylation measurement. We investigated whether this association was modified by genotype and phenotype.Results: An interquartile range (IQR) increase in BC over a 90-day period was associated with a decrease of 0.31% 5-methylcytosine (5mC) (95% confidence interval, 0.12–0.50%) in Alu. An IQR increase in SO4 over a 90-day period was associated with a decrease of 0.27% 5mC (0.02–0.52%) in LINE-1. The glutathione S-transferase mu-1–null genotype strengthened the association between BC and Alu hypomethylation.Conclusion: Prolonged exposure to BC and SO4 particles was associated with hypomethylation of two types of repetitive elements. 相似文献
999.
Merino J Aller MA Rubio S Arias N Nava MP Loscertales M Arias J Arias JL 《Digestive diseases and sciences》2011,56(8):2309-2317
Background
Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the rat.Aim
We have studied an experimental model of portal hypertension based on a triple partial portal vein ligation in the rat to verify this hypothesis.Methods
One month after portal hypertension we assayed in the splanchnic area (liver, small bowel and mesenteric lymph nodes) and in the central nervous system (hippocampus and cerebellum) fractalkine (CX3CL1) and stromal cell-derived factor alpha (SDF1-??) as well as their respective receptors (CX3CR1 and CXCR4) because of their key role in inflammatory processes.Results
The significant increase of fractalkine in mesenteric lymph nodes (P?<?0.05) and its receptor (CX3CR1) in the small bowel (P?<?0.05) and hippocampus (P?<?0.01), associated with the increased expression of SDF1-?? in the hippocampus (P?<?0.01) and the cerebellum (P?<?0.01) suggest that prehepatic portal hypertension in the rat induces important alterations in the expression of chemokines in the gut-brain axis.Conclusion
The present study revealed that portal hypertension is associated with splanchnic-brain inflammatory alterations mediated by chemokines. 相似文献1000.
Ana María Madrid Jaime Poniachik Rodrigo Quera Carlos Defilippi 《Digestive diseases and sciences》2011,56(1):155-160