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排序方式： 共有866条查询结果，搜索用时 15 毫秒
851.
Ryan C. Locke Elisabeth A. Lemmon Ellen Dudzinski Sarah C. Kopa Julianna M. Wayne Jaclyn M. Soulas Luis De Taboada Megan L. Killian 《Journal of orthopaedic research》2020,38(8):1866-1875
Tendon rupture can occur at any age and is commonly treated nonoperatively, yet can result in persisting symptoms. Thus, a need exists to improve nonoperative treatments of injured tendons. Photobiomodulation (PBM) therapy has shown promise in the clinic and is hypothesized to stimulate mitochondrial-related metabolism and improve healing. However, the effect of PBM therapy on mitochondrial function during tendon maturation and healing are unknown, and its effect on tendon structure and function remain unclear. In this study, near-infrared light (980:810 nm blend, 2.5 J/cm2) was applied at low (30 mW/cm2) or high (300 mW/cm2) irradiance to unilateral Achilles tendons of CD-1 mice during postnatal growth (maturation) as well as adult mice with bilateral Achilles tenotomy (healing). The chronic effect of PBM therapy on tendon structure and function was determined using histology and mechanics, and the acute effect of PBM therapy on mitochondrial-related gene expression was assessed. During maturation and healing, collagen alignment, cell number, and nuclear shape were unaffected by chronic PBM therapy. We found a sex-dependent effect of PBM therapy during healing on mechanical outcomes (eg, increased stiffness and Young's modulus for PBM-treated females, and increased strain at ultimate stress for PBM-treated males). Mitochondria-related gene expression was marginally influenced by PBM therapy for both maturation and healing studies. This study was the first to implement PBM therapy during both growth and healing of the murine tendon. PBM therapy resulted in marginal and sex-dependent effects on the murine tendon. Clinical significance: PBM may be beneficial for tendon healing because functional remodeling improves without adverse effects. 相似文献
852.
Marita Troye-Blomberg Charles Arama Jaclyn Quin Ioana Bujila Ann-Kristin Östlund Farrants 《Scandinavian journal of immunology》2020,92(4):e12932
There are an estimated over 200 million yearly cases of malaria worldwide. Despite concerted international effort to combat the disease, it still causes approximately half a million deaths every year, the majority of which are young children with Plasmodium falciparum infection in sub-Saharan Africa. Successes are largely attributed to malaria prevention strategies, such as insecticide-treated mosquito nets and indoor spraying, as well as improved access to existing treatments. One important hurdle to new approaches for the treatment and prevention of malaria is our limited understanding of the biology of Plasmodium infection and its complex interaction with the immune system of its human host. Therefore, the elimination of malaria in Africa not only relies on existing tools to reduce malaria burden, but also requires fundamental research to develop innovative approaches. Here, we summarize our discoveries from investigations of ethnic groups of West Africa who have different susceptibility to malaria. 相似文献
853.
Bambarendage P. U. Perera Christopher Faulk Laurie K. Svoboda Jaclyn M. Goodrich Dana C. Dolinoy 《Environmental and molecular mutagenesis》2020,61(1):176-192
The genetic material of every organism exists within the context of regulatory networks that govern gene expression, collectively called the epigenome. Epigenetics has taken center stage in the study of diseases such as cancer and diabetes, but its integration into the field of environmental health is still emerging. As the Environmental Mutagenesis and Genomics Society (EMGS) celebrates its 50th Anniversary this year, we have come together to review and summarize the seminal advances in the field of environmental epigenomics. Specifically, we focus on the role epigenetics may play in multigenerational and transgenerational transmission of environmentally induced health effects. We also summarize state of the art techniques for evaluating the epigenome, environmental epigenetic analysis, and the emerging field of epigenome editing. Finally, we evaluate transposon epigenetics as they relate to environmental exposures and explore the role of noncoding RNA as biomarkers of environmental exposures. Although the field has advanced over the past several decades, including being recognized by EMGS with its own Special Interest Group, recently renamed Epigenomics, we are excited about the opportunities for environmental epigenetic science in the next 50 years. Environ. Mol. Mutagen. 61:176–192, 2020. © 2019 Wiley Periodicals, Inc. 相似文献
854.
Jaclyn K. Schwartz Angelica Fermin Kimberly Fine Nathalie Iglesias Danika Pivarnik Stephanie Struck 《Disability and rehabilitation. Assistive technology》2020,15(2):141-147
AbstractThree-dimensional (3D) printing now allows rehabilitation professionals to design and manufacture assistive technologies in a few hours. However, there is limited guidance for researchers and clinicians for implementing 3D printing assistive technology interventions and measuring their outcomes. The goal of this study was to develop a standardized 3D printing assistive technology intervention and a research methodology, using pillboxes as an example. Fourteen pillbox users engaged in a study comparing their use of an off-the-shelf pillbox to a customized 3D printed pillbox. Study outcomes were evaluated on feasibility (recruitment capability, study procedures and outcome measures, acceptability of the study procedures, the research team’s ability to manage and implement the study, and the participant’s preliminary response to intervention). Participant outcomes were measured on satisfaction with the device and medication adherence. Fourteen participants completed the study and received customized 3D printed pillboxes. The study design performed well on all aspects of feasibility except the research team’s ability to manage and implement the study, as they experienced several technical issues. Notably, the participants reported improved device satisfaction and medication adherence with the 3D printed device with large effect sizes. The 3D printed assistive technology intervention is a replicable process that supports professionals in printing their own assistive technologies. Recommendations are made to further enhance feasibility of 3D printing assistive technology studies. Future research is warranted.
- IMPLICATIONS FOR REHABILITATION
3D printing is an increasingly feasible approach allowing for the design and manufacture of customized assistive technology
Evaluation for assistive technology that will be 3D printed should include information about the person’s activities, routines, skills, abilities, and preferences. Evaluation of outcomes should include satisfaction with the device and a functional measure.
3D printed assistive technology interventions should include the collaboration between the assistive technology professional and client. It should also include device training.
Future 3D printing research studies should report pragmatic data including printing device, time to print, and number of errors.
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856.
Andrew C. Hale Sharon M. Nelson Jaclyn Reckow Robert J. Spencer 《Journal of clinical psychology》2020,76(9):1754-1774
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859.
Kelvin K. W. Chan Helen Guo Sierra Cheng Jaclyn M. Beca Ruby Redmond‐Misner Wanrudee Isaranuwatchai Lucy Qiao Craig Earle Scott R. Berry James J. Biagi Stephen Welch Brandon M. Meyers Nicole Mittmann Natalie Coburn Jessica Arias Deborah Schwartz Wei F. Dai Scott Gavura Robin McLeod Erin D. Kennedy 《Cancer Medicine》2020,9(1):160-169
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